Clinical trials: cyclosporine
Atopic Dermatitis
Photophoresis Versus Ciclosporine in Severe Atopic Dermatitis
Severe atopic dermatitis (AD) is a recurrent and debilitating disease often requiring systemic immunosuppressive treatment. The efficacy of cyclosporine A (CsA) is well proven but potential side effects are concerning.
- Trial name
- NCT02226068
- Testing
- Cyclosporine A (CsA), Extracorporeal photopheresis (ECP)
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Kidney Transplantation
Comparison of the Two Immunosuppressive Regimens Based on Tacrolimus and Cyclosporine Following Kidney Transplantation
The purpose of this study is to evaluate and compare, in the single center setting, the safety, efficacy and cost-effectiveness of the two standard immunosuppressive regimens based on tacrolimus and cyclosporine.
- Trial name
- NCT00204191
- Testing
- tacrolimus
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Uniwersytet Mikolaja Kopernika w Toruniu
Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute
Feasibility of Haploidentical Hematopoietic Stem Cell Transplantation Using CAMPATH-1H
Many patients suffering various malignant and non-malignant diseases need hematopoietic stem cell transplantation from a healthy person. In the majority of cases there is no matched related or unrelated donor.
- Trial name
- NCT00458250
- Testing
- Haploidentical hematopoietic stem cell transplantation, Busulfan, Cyclophosphamide
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Tehran University of Medical Sciences
Chronic Graft Versus Host Disease
Extracorporeal Photopheresis (ECP) With Methoxsalen for Chronic Graft Versus Host Disease (cGVHD)
Chronic graft-versus-host disease (cGVHD) is a long-lasting complication that can occur after transplants. The transplanted cells seem to fight with the patient's own cells.
- Trial name
- NCT01380535
- Testing
- ECP Methoxsalen, Standard of Care
- Where
- 32 sites in United States, Austria and 6 more
- Volunteers
- 60 people
- Sponsor
- Mallinckrodt
Immunosuppression, Renal Failure
The Vienna Prograf and Endothelial Progenitor Cell Extension Study
Conversion of renal transplant recipients from either tacrolimus or cyclosporin A to tacrolimus modified release to investigate the effects of the MDR1/CYP450 genotype on the trough blood levels of tacrolimus with modified…
- Trial name
- PEP-X (NCT03751332)
- Testing
- Tacrolimus
- Volunteers
- 87 people
- Sponsor
- Medical University of Vienna
Dry Eye Syndromes
The Effect of Cyclosporin Before Cataract Surgery
To evaluate the effect of cyclosporine eye drop before cataract surgery for the prevention of post cataract surgery dry eye syndrome.
- Trial name
- NCT04426240
- Testing
- Cyclosporine microemulsion
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Kidney Transplantation
Therapeutic Drug Monitoring (TDM) of Cyclosporine in Kidney Transplant Patients by Dried Blood Spot Assay. Interest and Feasibility.
Ciclosporin A (CsA) is an immunosuppressive drug used in organs and tissues transplantations (kidney, heart, liver, bone marrow ...) to prevent rejection, and in different autoimmune or inflammatory diseases.
- Trial name
- CICLOSPOT (NCT02830191)
- Volunteers
- 22 people
- Sponsor
- University Hospital, Caen
Dry Eye
Tear Dynamics After Restasis Treatment in Dry Eye Patients
Observe the changes of tear volume in dry eye patients after Restasis treatment of 3 months and during 6-month follow-up after discontinuation of study treatment.
- Trial name
- NCT00706940
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Renal Transplantation
Extension Study of Enteric-coated Mycophenolate Sodium in Combination With Full Dose or Reduced Dose Cyclosporine Microemulsion in Patients With de Novo Kidney Transplants
This extension study is considered to allow patients being treated with EC-MPS to collect further information on the long-term safety of this drug.
- Trial name
- NCT00238940
- Testing
- Enteric-Coated Mycophenolate Sodium (EC-MPS)
- Volunteers
- 55 people
- Sponsor
- Novartis
Lung Transplantation
Postconditioning by Cyclosporin A in Pulmonary Transplantation
The morbidity and mortality of patients undergoing lung transplantation in the acute phase following surgical intervention is mainly due to the primary graft failure (PGF).
- Trial name
- CsA Poumon (NCT02876250)
- Testing
- Cyclosporine A
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Gingival Overgrowth
Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth
This study will examine common features of gingival overgrowth (excessive growth of the gums around the teeth) that develops in patients with the hereditary form of the condition and in those who develop the condition as a side…
- Trial name
- NCT00104026
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Kidney Transplantation
Everolimus in Combination With Cyclosporine Microemulsion in de Novo Renal Transplant Recipients
The purpose of the study in de novo renal transplant patients is to evaluate the effect on renal function of an optimized new regimen in comparison with the standard everolimus exposure plus a low-dose cyclosporine microemulsion…
- Trial name
- NCT00170885
- Testing
- Everolimus
- Where
- Switzerland
- Sponsor
- Novartis
Atopic Dermatitis
A Long-term Study of Baricitinib (LY3009104) With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis That Are Not Controlled With Cyclosporine or for Those Who Cannot Take Oral Cyclosporine Because it is Not Medically Advisable
The purpose of this study is to determine the efficacy and safety of baricitinib in combination with topical corticosteroids in participants with moderate to severe atopic dermatitis who have experienced failure to cyclosporine…
- Trial name
- BREEZE-AD4 (NCT03428100)
- Testing
- Baricitinib, Topical corticosteroid
- Where
- 103 sites in Austria, Belgium and 12 more
- Volunteers
- 463 people
- Sponsor
- Eli Lilly and Company
Dry Eye Syndromes
Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group
A Multicenter, Randomized, Double-blind Phase Ⅲ Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group 12 Weeks After Treatment in Moderate to Severe Dry Eye Disease
- Trial name
- Cyclosporine (NCT01768312)
- Testing
- Cyclosporine ophthalmic solution
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Lymphoma
Autologous Peripheral Stem Cell Transplant in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy, such as ifosfamide, etoposide, and carboplatin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00345865
- Testing
- carmustine, cyclophosphamide, etoposide
- Where
- United States
- Volunteers
- 473 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pharmacokinetics, Healthy
Drug-Drug Interaction Study Between Colchicine and Cyclosporine
Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). Cyclosporine is a potent inhibitor of both CYP3A4 and P-gp.
- Trial name
- NCT00983931
- Testing
- Colchicine, Cyclosporine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Graft vs Host Disease
Acute Graft-Versus-Host Disease (aGvHD) Prophylaxis With ATG-Fresenius in Matched Unrelated Donor-Stem Cell Transplantation (MUD-SCT)
The study aim is to evaluate the influence of the anti-T-lymphocyte globulin ATG-Fresenius S given pre-transplant in addition to standard GvHD prophylaxis with cyclosporine A and a short course of methotrexate with respect to…
- Trial name
- NCT00655343
- Testing
- ATG-Fresenius S
- Where
- Germany
- Volunteers
- 202 people
- Sponsor
- Neovii Biotech
Psoriasis
Evaluation of Vitamin D Levels in Psoriasis Patients
The purpose of this research study is to find out more about the relationship between vitamin D and psoriasis.
- Trial name
- NCT01903317
- Testing
- Topical Therapy, Phototherapy and Systemic Therapy, Biologic Therapy
- Where
- United States
- Sponsor
- University of California, Irvine
Psoriasis
An Investigational Study of Cyclosporine on Experimental Medication BMS-986165 in Healthy Male Participants
This is an investigational study of Cyclosporine on the experimental medication BMS-986165 in healthy male participants.
- Trial name
- NCT03419910
- Testing
- BMS-986165, Cyclosporine
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Atopic Dermatitis
Dupilumab and House Dust Mite Immunotherapy in Patients With Atopic Dermatitis
Severe atopic dermatitis (AD) is a complex disease requiring systemic treatment. This study aimed to assess the effectiveness of combined therapy consisting of dupilumab and sublingual dust mite allergen immunotherapy (SLIT-HDM)…
- Trial name
- DuHDM (NCT06509243)
- Testing
- tablets Acarizax, dupilumab, cyclosporine
- Where
- Poland
- Volunteers
- 132 people
- Sponsor
- Medical University of Silesia
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