Clinical trials: flow cytometry
Colorectal Cancer
T Helper Cytokines in End Stage Colorectal Cancers
Colorectal cancers are the third most common type of cancer in the world. Peritoneal carcinomatosis and intraabdominal acid development occur in advanced stages of colorectal cancers.
- Trial name
- NCT04540146
- Testing
- Flow-Cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Training and Research Hospital
Haematological Malignancy
Kinectics of Donor-specific Anti-HLA Antibody After HLA-incompatible Allogeneic Haematopoietic Stem Cell Transplantation
Donor specific anti-HLA antibody (DSA) is closely related not only to primary graft rejection (GR) after HLA-incompatible transplantation, but also to the occurrence of primary PGF.
- Trial name
- NCT06395220
- Testing
- Detection of donor-specific anti-HLA antibody (DSA)
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Peking University People's Hospital
Transplant; Failure, Kidney
Effects of Sevoflurane and Desflurane on Treg
This prospective interventional study aims to compare sevoflurane and desflurane anesthetic agents on regulatory T cell (Treg) numbers and its cytokine production in patients undergoing Living Donor Kidney Transplant (LDKT).
- Trial name
- NCT02559297
- Testing
- Sevoflurane, Desflurane
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Multiple Myeloma and Plasma Cell Neoplasm
Interferon-gamma or Aldesleukin and Vaccine Therapy in Treating Patients With Multiple Myeloma
RATIONALE: Biological therapies, such as interferon-gamma and aldesleukin, may stimulate the immune system in different ways and stop cancer cells from growing.
- Trial name
- NCT00616720
- Testing
- aldesleukin, idiotype-pulsed autologous dendritic cell vaccine APC8020, recombinant interferon gamma
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Endometriosis
Evaluation of M1 and M2 Macrophages in Endometriotic Tissue of Women Affected by Endometriosis at Different Stages.
Accumulating evidence suggests that the peritoneal microenvironment of women affected by endometriosis undergoes a number of local inflammatory-reparative phenomena, with the involvement of resident macrophages, and the…
- Trial name
- NCT03136978
- Testing
- Evaluation of M1 and M2 macrophages by flow cytometry.
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Messina
Chronic Lymphocytic Leukemia
Personalized Multi-peptide Vaccination in CLL Patients
The aim of this study is to evaluate the efficiency along with safety and toxicity of a personalizied multi-peptide vaccine in combination with the TLR1/2 ligand XS15 in CLL patients undergoing ibrutinib-based regimes.
- Trial name
- NCT04688385
- Testing
- Multipeptide Vaccine+ XS15
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Myocardial Infarction
Intravenous MSC Therapy on Ischemia-Reperfusion Injury in Patients With Myocardial Infarction
The investigators scheduled to assess the value of intravenous injection of WJ-MSC in patients with ST-segment elevation myocardial infarction (STEMI).
- Trial name
- NCT03533153
- Testing
- WJ-MSC cells implantation, CTSTMD PBS without WJ-MSC, Conventional drug therapy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Acute Myeloid Leukemia
Acute Myeloid Leukemia and Markers of Leukemia Stem Cells (CLL1 and CD45RA)
Acute myeloid leukemia (AML) is a malignant disorder of the bone marrow and the most common form of acute leukemia in adults. Patient with AML have the shortest survival compared to other forms of leukemia.
- Trial name
- NCT06297551
- Testing
- Quantification of blood cells positive for CLL1 and CD45RA surface markers by flow cytometry
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Suhu Liu
Hodgkin Lymphoma, Stage I Adult Hodgkin Lymphoma
Lopinavir and Ritonavir in Improving Immune Response to Vaccines in Patients With Complete Remission Following A Bone Marrow Transplant for Hodgkin Lymphoma
RATIONALE: HIV protease inhibitors, including Lopinavir/Ritonavir have intrinsic anti-apoptotic properties in addition to their anti-viral effect on HIV.
- Conditions
- Hodgkin Lymphoma, Stage I Adult Hodgkin Lymphoma, Stage II Adult Hodgkin Lymphoma, Stage III Adult Hodgkin Lymphoma
- Trial name
- NCT01165645
- Testing
- lopinavir, ritonavir, polymerase chain reaction
- Where
- United States
- Sponsor
- Mayo Clinic
Cardiac Surgery
Diagnostic Interest of Leukocyte Immunophenotyping Using Multiparameter 8-color Flow Cytometry in Heart Surgery
In septic patients, Septiflux1 study identified immature granulocytes which may have a diagnostic and prognostic interest. However, with these preliminary results it is not possible to make a difference between what is linked to…
- Trial name
- INFLUX (NCT02216019)
- Testing
- Whole blood
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Limoges
Leukemia
Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about biomarkers related to cancer.
- Trial name
- NCT01138306
- Testing
- gene expression analysis, mutation analysis, flow cytometry
- Volunteers
- 149 people
- Sponsor
- Children's Oncology Group
Stem Cell Surveillance
Acute Effects on Stem Cell Surveillance
The goal for this clinical trial is to compare acute immune effects of three nutraceutical ingredients and blends to a placebo.
- Trial name
- NCT07341178
- Testing
- Anthocyanin-rich berry extract, Anthocyanin-rich flower/leaf extract, Berry /leaf blend
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Atheroma; Myocardial
Plaque Erosion Prospective Study ii
Plaque erosion is associated with myocardial infarction (MI) in about 30% of cases and may require a different management approach to plaque rupture.
- Trial name
- PEPSii (NCT04701385)
- Testing
- Optical Coherence Tomography (OCT)
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Acute T-Cell Leukemia-Lymphoma
Campath-1H for Treating Adult T-Cell Leukemia/Lymphoma
This study will examine the safety and effectiveness of Alemtuzumab (Campath-1H) for treating patients with adult T-cell leukemia/lymphoma (ATL).
- Trial name
- NCT00061048
- Testing
- Alemtuzumab
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Alopecia Areata
Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5%
It is thought that alopecia areata occurs as the result of an inappropriate response of the body's own immune system to certain substances in or around the hair follicle.
- Trial name
- NCT00176943
- Testing
- Aldara Cream 5%
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hordinsky, Maria K., MD
Nasal Polyps
The Activation of Hippo Pathway in Nasal Polyps
Hippo-YAP pathway is a newly discovered pathway controlling the growth, and plays important roles in the regulation of stem cell function and tissue regeneration.
- Trial name
- NCT03151954
- Testing
- functional endonasal sinus surgery, nasal septal construction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Myelodysplastic Syndromes
Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes: Protocol for a Diagnostic Accuracy Study
Myelodysplastic syndromes (MDS) are clonal bone marrow neoplasms characterized by dysplasia and ineffective hematopoiesis leading to peripheral blood cytopenias, with an increased risk of progression to acute myeloid leukemia.
- Trial name
- MPO-MDS-Valid (NCT05175469)
- Testing
- Flow cytometric analysis of neutrophil myeloperoxidase expression
- Where
- 8 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Anemia, COPD
The Impact of Anemia of Chronic Disease on Chronic Obstructive Pulmonary Disease Patients
Hypothesis: The first part of the study is a survey on the prevalence of anemia of chronic disease (ACD) among COPD patients. The 2nd and 3rd part will test 2 null hypotheses (Ho): 1.serum inflammatory markers and plasma…
- Trial name
- NCT01033175
- Testing
- maximal cardiopulmonary exercise testing, peripheral blood samples
- Where
- 2 sites in Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Myeloproliferative Disorders, Myeloproliferative Disorders (MPD)
Investigation of Dysregulated Signaling in MPD Via Multiparameter Phospho-specific Flow Cytometry
The objective of this study is to better understand the underlying pathogenetic mechanisms of myeloproliferative disorders (MPDs).
- Trial name
- NCT01144780
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Metastatic Cancer, Sarcoma
Combination Chemotherapy, Radiation Therapy, and Sargramostim Before and After Surgery in Treating Patients With Soft Tissue Sarcoma That Can Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00652860
- Testing
- aerosol sargramostim, sargramostim, cisplatin
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic