Clinical trials: therapeutic conventional surgery
Hepatectomy, Laparoscopy
Multimodal Image Registration for Helping Laparoscopic Liver Surgery Guidance
Multimodal intraoperative minimal-invasive (laparoscopic or robotic) liver surgery images will be registered to each other. Explicitly, these are the ultrasound and laparoscope images.
- Trial name
- IMMORTALLS (NCT06044909)
- Testing
- Minimal invasive hepatectomy, intraoperative stage, Minimal invasive hepatectomy, postoperative stage, Preoperative data collection
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aortic Valve Stenosis
OUTcomes Evaluation of Current Therapeutic STrategies for Severe Aortic Valve steNosis anD the agING Population in ITALY
In 2015 the Italian Ministry of Health invited the Cardiac Research Hospitals of Italy to constitute a Cardiac Network. The aim of the network is to facilitate and promote scientific and technological research in the setting of…
- Trial name
- OUTSTANDING (NCT05778773)
- Testing
- TAVR (Transcatheter Aortic Valve Replacement), AVR (Aortic Valve Replacement)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Policlinico S. Donato
Breast Cancer - Female
Effects of Negative Pressure Wound Bandaging After Mastectomy
Participant information sheet: Mastectomy is a surgical method used to treat breast cancer. A mastectomy involves the removal of the entire breast. A common postoperative complication after a mastectomy is seroma, i.e.
- Trial name
- NEPTAM (NCT07607366)
- Testing
- PICO negative pressure wound therapy by Smith and Nephew
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Dalarna County Council, Sweden
Locally Advanced Cervical Cancer
Assessment of Prognosis Using Peripheral Blood Circulating Tumor DNA in Patients With Cervical Cancer
This observational study is conducted to assess the value of using peripheral blood ctDNA to detect dynamic changes in HPV and genetic variants in predicting the prognosis of patients with locally advanced cervical cancer, as…
- Trial name
- NCT05602831
- Testing
- detect HPV and genetic variants
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Fudan University
Adenocarcinoma of the Pancreas, Stage III Pancreatic Cancer
Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer
This phase I trial is studying the side effects and best dose of stereotactic radiation therapy and nelfinavir mesylate when given together with gemcitabine hydrochloride, leucovorin calcium, and fluorouracil in treating patients…
- Trial name
- NCT01068327
- Testing
- gemcitabine hydrochloride, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Nebraska
Prostate Carcinoma, Prostate Small Cell Neuroendocrine Carcinoma
Autologous T Cells Lentivirally Transduced to Express L1CAM-Specific Chimeric Antigen Receptors in Treating Patients With Locally Advanced and Unresectable or Metastatic Small Cell Neuroendocrine Prostate Cancer
This phase I trial studies the side effects and best dose of autologous CD8+ and CD4+ lentivirally transduced to express L1CAM-specific chimeric antigen receptor (CAR) and EGFRt mutation specific T cells and to see how well they…
- Conditions
- Prostate Carcinoma, Prostate Small Cell Neuroendocrine Carcinoma, Stage III Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- NCT06094842
- Testing
- Bendamustine, Biopsy, Biospecimen Collection
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Atopic Dermatitis
Sensory Nociceptive Nerve Fibers, Key Regulator of Immune Response Type 2 in Atopic Dermatitis
The skin is innervated by a network of nociceptive sensory neurons (nociceptors) whose primary function is the transmission of pain and pruritus signals to the central nervous system.
- Trial name
- IMMCEPTION (NCT04193670)
- Testing
- Clinical examination, Biopsies, Blood test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Colorectal Cancer
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00023751
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 180 sites in United States, Canada and 1 more
- Volunteers
- 320 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Brain and Central Nervous System Tumors
Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving a chemotherapy drug before surgery or radiation therapy may shrink the tumor so that it can be removed…
- Trial name
- NCT00025077
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling
Chronic periodontitis is an infectious disease resulting in inflammation of the teeth support structures, progressive periodontal attachment loss and bone loss.
- Trial name
- NCT03498404
- Testing
- Photodynamic Therapy, scaling and root planing
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pulmonary Tuberculosis
Induced Sputum Versus Bronchoscopy in Smear Negative Pulmonary Tuberculosis
This is a randomised study that compares different diagnostic approaches for diagnosing pulmonary tuberculosis in patients suspected of pulmonary tuberculosis in whom the three classic (non-induced) sputum samples didn't show…
- Trial name
- NCT01011543
- Testing
- Diagnostic techniques in pulmonary tuberculosis
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Breast Cancer
The Impact of Preoperative Breast MRI in Patients With Breast Cancer Selected for Breast Conserving Surgery
The purpose of this prospective observational study is to evaluate the impact of preoperative breast MRI in patients with breast cancer selected for breast- conserving surgery.
- Trial name
- NCT01391806
- Where
- Norway
- Volunteers
- 145 people
- Sponsor
- Nordlandssykehuset HF
Dental Implant
The Accuracy of s-CAIS Compared With c-LIS
To compare the static computer-aided implant surgery (s-CAIS) and conventional laboratory-guided implant surgery (c-LIS) in terms of accuracy for single tooth replacement in posterior areas.
- Trial name
- NCT05361226
- Testing
- Accuracy measurement
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Inadequate or Impaired Respiratory Function
Positive Airway Pressure Versus Breathing Exercises With Load Inspiratory in Patients Undergoing Bariatric Surgery
Obesity, due to excess fat in the thoracoabdominal region, can promote changes in respiratory function and lung function, leading to reduction in lung volume and capacity.
- Trial name
- NCT02682771
- Testing
- Bilevel positive airway pressure, PowerBreathe, Conventional Respiratory Physiotherapy (CRP)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Macular Holes
To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular Holes.
To compare anatomic and functional results, and to evaluate postoperatively the healing process in 3 different techniques for the closure of the refractory macular holes (MH).
- Trial name
- NCT05396209
- Testing
- Hydrated Amniotic Membrane Plug, ILM filling, Conventional ILM peeling
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
Valvular Heart Disease, Treatment Adherence and Compliance
Valvular Heart Disease in Jiangxi Province
Study Title: A real-world study of valvular heart disease in Jiangxi Province Research Objectives: ① Main objectives: To examine the current incidence of valvular heart disease in Jiangxi Province, to establish a "Formal…
- Trial name
- JXVD (NCT05523193)
- Testing
- Formal treatment model
- Where
- China
- Volunteers
- 1,052 people, healthy volunteers welcome
- Sponsor
- Xiao Huang
Dysphagia
Improving Diagnostic Standards in Dysphagia
The purpose of this research is to understand the normal function of swallowing and respiratory muscles in order to establish normal parameters.
- Trial name
- NCT04773184
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing, Videofluoroscopic Swallowing Study, Voluntary Peak Cough Flow Testing
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Florida
Uterine Factor Infertility
Uterus Transplantation to Treat Infertility
This research study will use uterus transplantation to treat uterine factor infertility, also known as the inability to bear children due to not having a uterus.
- Trial name
- OPRTUNTI (NCT05646992)
- Testing
- Uterine Allotransplantation, Tacrolimus, Imuran
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Osteoporosis, Lumbar Disc Herniation
Baduanjin With Resistance Training Program
The purpose of this study is to improve symptoms of Lumbar Disc Herniation (LDH) and Osteoporosis (OP) by implementing an evidence-based Baduanjin exercise to reduce pain and increase muscle strength and quality of life in…
- Trial name
- NCT06853132
- Testing
- Baduanjin with Resistance Training Program
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Yale University
Total Hip Arthroplasty
Rehabilitation in Total Hip Arthroplasty Through a Mobile Application
This observational retrospective study aims to assess the rehabilitation outcomes of patients who underwent total hip arthroplasty (THA) and were monitored through a mobile application versus those who were not.
- Trial name
- HIP-App (NCT06606158)
- Testing
- Exercises program, App exercises program
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Universidad Pontificia Comillas
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