Clinical trials: therapeutic conventional surgery
Chronic Stroke, Dual Task
Multiple Effects of Dual-Task Focused Training in Individuals with Chronic Stroke
The aim of this study is to comprehensively investigate dual-task-focused training on balance, functionality, anxiety, healthy function and quality of life in chronic individuals.
- Conditions
- Chronic Stroke, Dual Task, Physiotherapy
- Trial name
- NCT06559930
- Testing
- Traditional Neurological Rehabilitation + Dual Task Focused Training, Traditional Neurological Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- University of Beykent
Stage III Hepatocellular Carcinoma AJCC v8, Stage III Intrahepatic Cholangiocarcinoma AJCC v8
Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer
This early phase I trial studies the side effects of autologous dendritic cells and a vaccine called Prevnar in combination with immune checkpoint inhibition (with bevacizumab and atezolizumab or druvalumab) in treating patients…
- Conditions
- Stage III Hepatocellular Carcinoma AJCC v8, Stage III Intrahepatic Cholangiocarcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8, Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
- Trial name
- NCT03942328
- Testing
- Atezolizumab, Bevacizumab, External Beam Radiation Therapy
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Mayo Clinic
Lung Edema, Hip Fractures
Ultrasound in Evaluation of Preoperative Fluid Management of Hip Fracture Surgery Patients
Goal directed fluid therapy is a new standard surgical procedure which is successful in patients undergoing hip revision arthroplasty, There has been a reduction of postoperative complications, most importantly surgery with a…
- Trial name
- NCT05916599
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Brain Tumor, Central Nervous System Tumors
Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Giving a chemotherapy drug before surgery may shrink the tumor so that it is no longer present by…
- Conditions
- Brain Tumor, Central Nervous System Tumors, Childhood Germ Cell Tumor
- Trial name
- NCT00047320
- Testing
- carboplatin, etoposide, ifosfamide
- Where
- 106 sites in United States, Australia and 3 more
- Volunteers
- 104 people
- Sponsor
- Children's Oncology Group
Esophageal Cancer
Cisplatin, Irinotecan, and Radiation Therapy in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery
This phase II trial studies how well giving cisplatin and irinotecan hydrochloride together with radiation therapy works in treating patients with esophageal cancer or gastroesophageal junction cancer that can be removed by…
- Trial name
- NCT00316862
- Testing
- cisplatin, irinotecan hydrochloride, therapeutic conventional surgery
- Where
- 24 sites in United States
- Volunteers
- 82 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Adenocarcinoma of the Pancreas, Stage III Pancreatic Cancer
Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer
This phase I trial is studying the side effects and best dose of stereotactic radiation therapy and nelfinavir mesylate when given together with gemcitabine hydrochloride, leucovorin calcium, and fluorouracil in treating patients…
- Trial name
- NCT01068327
- Testing
- gemcitabine hydrochloride, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Nebraska
LMA Vs I Gel
Randomized Comparative Study Between Classic Laryngeal Mask Airway and I Gel Airway in Obese Patients Having BMI 35-40 During Elective Non Abdominal Surgery.
Invistigators study both supraglottic airway devices; the classic LMA and the I GEL mask are satisfactory devices providing high airway leaking pressures.
- Trial name
- NCT03843827
- Testing
- Laryngeal Mask Airway, I gel Airway
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Abdominal Aortic Aneurysm
Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair
To investigate the influence of limb remote ischemic preconditioning (LRIP) on mortality, hospitalization costs and quality of life in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
- Trial name
- NCT01910961
- Testing
- limb RIPC
- Volunteers
- 360 people
- Sponsor
- Cai Li
Stage III Prostate Cancer, Stage IV Prostate Cancer
Axitinib Before Surgery in Treating Patients With High-Risk Prostate Cancer
This randomized phase II trial studies how well axitinib works in treating patients with high-risk prostate cancer before undergoing surgery.
- Trial name
- NCT01385059
- Testing
- axitinib, therapeutic conventional surgery, enzyme-linked immunosorbent assay
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- City of Hope Medical Center
Persistent Atrial Fibrillation
Patient-TAILORed Ablation of Persistent AF Guided by Instantaneous Amplitude and Frequency Modulation Maps (TAILOR-AF)
Pulmonary vein isolation (PVI) is still considered the cornerstone of catheter ablation for patients with persistent atrial fibrillation (AF).
- Trial name
- TAILOR-AF (NCT05169320)
- Testing
- Subcutaneous implantable loop recorder (ILR) implantation, Mapping and catheter ablation, Minimally invasive surgical ablation via thoracoscopy
- Where
- 2 sites in Spain
- Volunteers
- 25 people
- Sponsor
- Hospital San Carlos, Madrid
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Genistein in Treating Patients With Prostate Cancer
RATIONALE: Genistein may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This randomized phase II trial is studying how well genistein works in treating patients with prostate…
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage II Prostate Cancer
- Trial name
- NCT01126879
- Testing
- genistein, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
Comprehensive Complication Index
Assessing the Effectiveness of Continuous Glucose Monitoring in Enhancing Surgical Outcomes for Patients With Diabetes
The goal of this multi-center, pragmatic, randomized controlled trial is to assess the effectiveness of continuous glucose monitoring (CGM) compared with conventional monitoring in enhancing surgical outcomes for diabetic…
- Trial name
- NCT06331923
- Testing
- Continuous glucose monitoring (CGM) device
- Where
- 8 sites in China
- Volunteers
- 9,877 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Mindfulness, Dental Implant
The Effect of Mindfulness Meditation During Dental Implant Surgery
The aim of this pioneer study was to evaluate the efficacy (heart rate value, blood pressure, oxygen saturation, cortisol levels, BIS monitoring, patients' anxiety) of Mindfulness Meditation as a sedative technique during dental…
- Trial name
- NCT05748223
- Testing
- Mindfulness Meditation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Exfoliation Glaucoma, Cataract
Comparison Of iStent to Laser in Exfoliation Glaucoma Helsinki Study Group
The purpose of the study is to investigate the efficacy of an iStent trabecular microbypass stent compared to selective laser trabeculoplasty in combination with cataract surgery in eyes with exfoliation glaucoma (EXF)
- Trial name
- COILEH (NCT04635020)
- Testing
- iStent, SLT-laser, Cataract surgery
- Where
- Finland
- Volunteers
- 285 people
- Sponsor
- Helsinki University Central Hospital
Surgical Wound Dehiscence
Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds
It is increasingly recognised that the debridement of devitalised, bacterially contaminated or senescent tissue is an essential component of the effective treatment of delayed healing wounds.
- Trial name
- NCT01050673
- Testing
- VERSAJET, Scalpel or blade
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Smith & Nephew, Inc.
Chronic Pain, Back Pain
Combining Mechanisms for Better Outcomes (COMBO)
To evaluate the effectiveness of Spinal Cord Stimulation (SCS) with multiple modalities as compared to conventional SCS in patients with chronic pain when using the Boston Scientific Spectra WaveWriter SCS System.
- Trial name
- COMBO (NCT03689920)
- Testing
- Boston Scientific Spectra WaveWriter™ Spinal Cord Stimulation (SCS) System
- Where
- 15 sites in United States
- Volunteers
- 174 people
- Sponsor
- Boston Scientific Corporation
Benign Prostatic Hyperplasia (BPH), Lower Urinary Tract Symptoms
Application of MOSES Technology in BPH
In this study the investigators intend to compare the surgical and functional results of two different modalities of the use of the Holmium laser in prostate enucleation.
- Trial name
- NCT04648176
- Testing
- Moses technology
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Lung Cancer
Combination Chemotherapy Followed by Radiation Therapy Before Surgery in Treating Patients With Stage IIIB NSCLC
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells.
- Trial name
- NCT00030810
- Testing
- Hyperfractionated, Taxotere/Cisplatin, conventional surgery
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- Swiss Cancer Institute
Diverticular Disease of Left Side of Colon
Quality of Life (QOL) After Elective Sigmoidectomy for Diverticular Diseases (DIVERTI)
Acute diverticulitis of the left colon is among the most common abdominal disorders. To date, both conservative therapy in uncomplicated stages and emergency surgery in perforated disease with peritonitis are consensual.
- Trial name
- DIVERTI-QDV (NCT04730765)
- Testing
- left elective colectomy (Surgical Experimental Group), antibiotic therapy (medical Control Group)
- Volunteers
- 220 people
- Sponsor
- University Hospital, Caen
Kidney Cancer
Sunitinib Malate Before and After Surgery in Treating Patients With Previously Untreated Metastatic Kidney Cancer
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT01024205
- Testing
- sunitinib malate, laboratory biomarker analysis, adjuvant therapy
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Barts and the London School of Medicine and Dentistry
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