Clinical trials: pills and oral medicines
Leiomyoma
Trial of Mifepristone for Fibroids
The purpose of this trial is to determine if low-dose mifepristone benefits women with symptomatic fibroids.
- Trial name
- NCT00133705
- Testing
- Mifepristone, Inert Capsule
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Chronic Kidney Disease, Disability
Dietary Acid Load, Kidney Function and Disability in Elderly
The purpose of this research study is to determine the effect of a bicarbonate supplement on kidney function and physical function.
- Trial name
- BICARB (NCT02691663)
- Testing
- Oral bicarbonate supplementation
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Wake Forest University Health Sciences
Scabies
Dose-finding Study of Moxidectin for Treatment of Scabies
The effective dose of moxidectin to treat human scabies is not known. This study aims to provide proof of concept that a single dose of moxidectin is effective in eliminating the scabies parasite in humans and to enable the…
- Trial name
- NCT03905265
- Testing
- Moxidectin Oral Product
- Where
- 5 sites in Australia, Austria and 1 more
- Volunteers
- 22 people
- Sponsor
- Medicines Development for Global Health
Nephropathy
A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
The purpose of this study is to compare the efficacy of oral N-acetylcysteine and intravenous sodium bicarbonate for the prevention of Contrast-Induced Nephropathy (CIN) after cardiac catheterization.
- Trial name
- PROTECt (NCT00579995)
- Testing
- Oral N-Acetylcysteine, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Penicillin Allergy
Penicillin Allergy Testing in STD Clinics
Demonstration project to implement penicillin allergy testing in STD outpatients using a questionnaire and pen allergy testing
- Trial name
- NCT04620746
- Testing
- Penicillin Major Determinant (PrePen) Skin Testing, Direct Oral challenge
- Where
- 2 sites in United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Insomnia
Safety, Tolerability and Efficacy Study of V117957 in Subjects With Insomnia Associated With Alcohol Cessation
The purpose of this study is to evaluate the safety, tolerability and efficacy of V117957 in subjects with alcohol use disorder (AUD) who experience insomnia associated with alcohol cessation, compared to placebo.
- Trial name
- NCT04035200
- Testing
- V117957 tablets
- Where
- 17 sites in United States
- Volunteers
- 114 people
- Sponsor
- Imbrium Therapeutics
Neuralgia
Safety And Efficacy Of Lyrica (Regulatory Post Marketing Commitment Plan)
The objective of this Investigation is to evaluate the safety and efficacy of Lyrica in medical practice. Also, occurrence of unknown and known adverse drug reactions (ADRs) in subjects treated with Lyrica will be monitored…
- Trial name
- RAINBOW (NCT01256593)
- Testing
- Pregabalin (Lyrica) capsule
- Volunteers
- 3,827 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Post Traumatic Stress Disorder, Alcohol Abuse
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD
Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid…
- Trial name
- NCT03852628
- Testing
- 2mg Buprenex and 380mg Vivitrol
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Hypothyroidism, Trisomy 21
Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients
Children with levothyroxine (T21) have developmental delay and other functional gastrointestinal (GI) issues that may negatively affect L-T4 tolerability and absorption.
- Trial name
- NCT04747275
- Testing
- Liquid stable levothyroxine (L-T4) Tirosint-SOL, Oral tablet levothyroxine (L-T4)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Children's Mercy Hospital Kansas City
Kidney Transplant, Hepatitis C
Utilization of Hepatitis C Positive Kidneys in Negative Recipients
To evaluate the safety and feasibility of transplanting kidneys from Hepatitis C virus (HCV) infected donors into recipients without HCV infection
- Conditions
- Kidney Transplant, Hepatitis C, HCV
- Trial name
- NCT03801707
- Testing
- Sofosbuvir / Velpatasvir Oral Tablet [Epclusa], Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet [MAVYRET]
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Ohio State University
Post-operative Pain, Sinus Surgery
Postoperative Pain Control in Septum and Sinus Surgery
This study will evaluate if the use of acetaminophen round the clock (scheduled doses) will lead to less opiate use in the first week post-operative (after surgery) in sinus/septum surgery patients.
- Trial name
- NCT04149964
- Testing
- Acetaminophen 325 mg Oral Tablet, Acetaminophen 650 mg Oral Tablet, OxyCODONE 5 mg Oral Tablet
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Corewell Health East
NASH - Nonalcoholic Steatohepatitis
Study of PXL065 in Patients With Nonalcoholic Steatohepatitis (NASH)
This study will assess the effect of 3 doses of PXL065 versus placebo on liver fat content in NASH patients after 36 weeks of treatment
- Trial name
- NCT04321343
- Testing
- PXL065
- Where
- 29 sites in United States
- Volunteers
- 117 people
- Sponsor
- Poxel SA
Healthy
Whole Body Protein Metabolism of a Whey/EAA Supplement Using Continuous Oral Stable Isotopes
To evaluate the validity of a continuous oral sip-feeding method of stable isotope tracer for the evaluation of whole-body protein metabolism in response to two different doses of an EAA/whey protein supplement (Low=6.3g and…
- Trial name
- NCT04612400
- Testing
- Oral amino acid tracer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Perinatal Depression, Post Partum Depression
Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period.
- Conditions
- Perinatal Depression, Post Partum Depression, Depression, Postpartum, Depression
- Trial name
- NCT04051320
- Testing
- Leuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Symptomatic Neurogenic Orthostatic Hypotension
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
To evaluate the time to treatment intervention in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Pure Autonomic Failure (PAF), Non-Diabetic Autonomic Neuropathy (NDAN) or Dopamine Beta Hydroxylase (DBH)…
- Trial name
- RESTORE (NCT02586623)
- Testing
- Droxidopa capsules
- Where
- 168 sites in United States
- Volunteers
- 453 people
- Sponsor
- H. Lundbeck A/S
Healthy Volunteers
A Study of Milvexian Using an IV Microtracer With Additional Formulation and Food Effect Comparison in Healthy Participants
The purpose of this study is to evaluate the absolute oral bioavailability (amount of drug entering the bloodstream) of spray-dried dispersion (SDD) milvexian capsules in the fed and fasted states, and to bridge the exposures…
- Trial name
- NCT04965389
- Testing
- BMS-986177 Oral Solution, [14C]BMS-986177 Solution for Infusion, BMS-986177 Spray-dried Dispersion Capsules
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Self-Harm, Depression
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents and young adults with NSSI (12 in each group…
- Conditions
- Self-Harm, Depression, Suicide
- Trial name
- NCT04005053
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Epilepsy
Fycompa Titration Intervals and Effects on Retention Rate
This study will aim to improve retention and tolerability by slowing the initial titration rate of perampanel from a standard up-titration rate of 2 week intervals to a slower up-titration rate consisting of 3 week intervals.
- Trial name
- NCT03457129
- Testing
- Perampanel Oral Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Cocaine Use Disorder
Treatment With Lorcaserin for Cocaine Use: The TLC Study
This project is a placebo-controlled, double-blind randomized trial evaluating the feasibility, tolerability, acceptability and adherence for lorcaserin among actively using, men who have sex with men (MSM) with cocaine use…
- Trial name
- TLC (NCT03192995)
- Testing
- lorcaserin, Substance use counseling, ACASI
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Glenn-Milo Santos
COVID-19
Povidone-Iodine Oral Rinse Study
This study is a two-arm, randomized, 2-phase study. Phase I will be double blinded clinical trial of the safety and efficacy of an antiseptic mouthwash solution on reducing SARS-CoV-2 load in COVID 19+ adult individuals.
- Trial name
- NCT05239598
- Testing
- Mouth rinse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
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