Clinical trials: sponsored by Aarhus University Hospital
Ligament; Laxity, Knee, Anterior Cruciate Ligament Injury
Treatment of Anterior Ligament Rupture With Internal Brace Repair - A Prospective Randomised Controlled Study.
The purpose of this study is to determine whether anterior cruciate ligament injury in patients wishing to return to sports activities may be treated with repair supplemented with internal brace compared with a standard operation…
- Trial name
- NCT03800225
- Testing
- Repair
- Where
- Denmark
- Volunteers
- 4 people
- Sponsor
- Aarhus University Hospital
Psoriasis Vulgaris
The Safety and Efficacy of a Novel HSP90 Inhibitor (CUDC-305) in the Treatment of Moderate to Severe Psoriasis.
This is a 12-week treatment, singlecenter, open-label, single-arm, dose-selection, proof of concept study to determine a dosage of HSP 90 inhibitor (CUDC-305) that is tolerable and demonstrates preliminary efficacy for use in…
- Trial name
- NCT03675542
- Testing
- CUDC-305
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Aarhus University Hospital
Psoriasis
Effect of Brodalumab Compared to Placebo on Vascular Inflammation in Moderate-to-severe Psoriasis
A randomised, double-blind, placebo-controlled, trial to evaluate the efficacy of brodalumab monotherapy on vascular and systemic inflammation by 18F-FDG-PET/CT in subjects with moderate-to-severe plaque-type psoriasis who are…
- Trial name
- NCT03478280
- Testing
- Brodalumab
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Postoperative; Dysfunction Following Cardiac Surgery
Stress, Anxiety and Type A Personality and Analgesics
Patients scheduled for elective cardiac surgery are preoperative evaluated using different personality type, stress and anxiety tests.
- Trial name
- SATA-1 (NCT02756598)
- Testing
- Sufentanil I, Sufentanil II, Propofol I
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Breast Neoplasms
SurgiMend® vs. Strattice™ in Direct to Implant Breast Reconstruction- A Prospective Randomized Trial
An increasing number of women undergo an immediate breast reconstruction, where the mastectomy and the breast reconstruction are performed in the same surgery.
- Trial name
- NCT02521623
- Testing
- SurgiMend® Acellular Dermal Matrix, Strattice™ Acellular Dermal Matrix
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Coronary Disease
Randomized Comparison of MynxGrip Vascular Closure Device and Manual Compression for Closure After Femoral Access Angiography. The Closure Devices Used in Every Day Practice Study, CLOSE-UP III Trial
Is the MynxGrip (test device) non-inferior to manuel compression (standard comparator) in the incidence of adverse access site related events in-hospital, at 30 days and at 6 months.
- Trial name
- CLOSE-UP III (NCT02237430)
- Testing
- MynxGrip, Manual compression
- Where
- Denmark
- Volunteers
- 869 people
- Sponsor
- Aarhus University Hospital Skejby
Cohabitation Patterns, Sexually Transmitted Diseases
Cohabitation Patterns and Incidence of Known and Suspected Sexually Transmitted Diseases
The number of infectious agents associated with risks of malignant hematologic diseases is non-negligible and include both viruses and bacteria.
- Trial name
- NCT03941158
- Volunteers
- 5,000,000 people
- Sponsor
- Aarhus University Hospital
Pulmonary Disease, Chronic Obstructive
Testing Cognitive Functions in Patients With COPD Using a Driving Simulator
Little is known about the causes and degree of cognitive dysfunction in patients with Chronic Obstructive Pulmonary Disease (COPD), especially their driving abilities.
- Trial name
- NCT02740673
- Testing
- Driving simulator
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Ligament; Laxity, Knee, Rupture of Anterior Cruciate Ligament
Anterior Cruciate Ligament-reconstruction: Quadriceps Tendon or Hamstrings Tendon? A Prospective Trial
The purpose of this study is to determine whether there is a difference in muscle strength after anterior cruciate ligament comparing 2 surgery technics. Using either autograft hamstrings tendon or a autograft quadriceps tendon.
- Trial name
- NCT02173483
- Testing
- Quadriceps graft
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Sarcoidosis, Pulmonary, Telerehabilitation
Feasibility & Effect of a Tele-rehabilitation Program in Pulmonary Sarcoidosis Pulmonary Sarcoidosis
Pulmonary sarcoidosis (PS) is defined as a multisystem granulomatous disorder of unknown cause affecting different vital organs, especially the lungs. PS manifest in reduction of pulmonary function.
- Trial name
- TeleSarco (NCT03914027)
- Testing
- Telerehabilitation
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Aarhus University Hospital
Myocardial Infarction
Acute Versus Subacute Angioplasty in Patients With NON-ST-Elevation Myocardial Infarction
Patients with acute myocardial infarction (AMI) are categorized according to the electrocardiogram (ECG) findings into: 1) patients with ST-Elevation Myocardial Infarction (STEMI), 2) patients with Bundle Branch Block Myocardial…
- Trial name
- NONSTEMI (NCT01638806)
- Testing
- Group I: Primary PCI
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital Skejby
Lymphoma, T-Cell, Peripheral
Alemtuzumab and CHOP in T-cell Lymphoma
The purpose of this study is to determine efficacy and safety of the monoclonal antibody MabCampath® (alemtuzumab) combined with chemotherapy in the treatment of T-cell lymphoma.
- Trial name
- ACT-1 (NCT00646854)
- Testing
- CHOP14 chemotherapy (cyclophosphamide, hydroxydaunorubicin, vincristin, prednison) plus G-CSF, combined with alemtuzumab, CHOP14 chemotherapy (see specification under Arm B) plus G-CSF
- Where
- 59 sites in Austria, Belgium and 9 more
- Volunteers
- 136 people
- Sponsor
- Aarhus University Hospital
Knee Stability, Patella Luxation
Reconstruction of the Medial Patellofemoral Ligament - A Randomised Controlled Trial Comparing Two Surgery Technics
The purpose of this present study is to determine which surgery technic provides the best clinical outcome after medial patellofemoral ligament reconstruction comparing suture anchors and screw fixation in medial femoral condyle.
- Trial name
- NCT02180685
- Testing
- Anchor fixation
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Myocardial Infarction, Chest Pain
Rapid Use of High-sensitive Cardiac Troponin I for ruling-in and Ruling-out of Acute Myocardial Infarction
Early rule-in or rule-out of myocardial infarction (MI) is essential in patients presenting to the Emergency Department with chest pain.
- Trial name
- RACING-MI (NCT03634384)
- Where
- Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Hyperthyroidism
Effects of Hyperthyroidism on Amount and Activity of Brown Adipose Tissue
The investigators wish to evaluate the effect of thyroid hormones on brown adipose tissue in humans in an observational study on patients with thyrotoxicosis.
- Trial name
- NCT02133040
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital
Delirium, Older Patients
Delirium in Geriatric Hospital Single-bed and Multibed Rooms
To investigate whether single-bed rooms can prevent and reduce incidence and duration of delirium compared to multi-bed rooms in elderly patients admitted to a geriatric department.
- Conditions
- Delirium, Older Patients, Admittance to Single-bed Rooms or Multi-bed Rooms
- Trial name
- NCT03199768
- Where
- Denmark
- Volunteers
- 1,014 people
- Sponsor
- Aarhus University Hospital
Paediatric Early Warning System
Paediatric Early Warning System - A Danish Multi-center Study
Critical illness in the patient and death can potentially be predicted and prevented. Deterioration of the clinical condition of hospitalised patients is often preceded by physiological changes up to 24 hours before death.
- Trial name
- NCT02433327
- Testing
- PEWS - trigger tool, RM - trigger tool
- Where
- Denmark
- Volunteers
- 8,000 people
- Sponsor
- Aarhus University Hospital
Delirium in Old Age, Cognitive Decline
Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) and Delirium in Geriatric Patients
To investigate the usefulness of the Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) to predict delirium in elderly patients admitted to Emergency Department (ED) with geriatric assessment and transferred to…
- Trial name
- Delirium (NCT03175276)
- Where
- Denmark
- Volunteers
- 315 people
- Sponsor
- Aarhus University Hospital
Heart Failure, Systolic
Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure
The study evaluates the pharmacokinetics of metformin in heart failure patients in acute and chronic state in relation to metformin transporter genotypes.
- Trial name
- MetKin (NCT02797340)
- Testing
- Blood draws and urine samples for metformin concentration measurements, Metformin
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Aarhus University Hospital
Heart Failure, Systolic
Effects of Metformin Treatment on Myocardial Efficiency in Patients With Heart Failure
The study evaluates the effects of metformin treatment on myocardial efficiency in heart failure patients. 36 patients will be randomized to three months of metformin or placebo treatment in addition to their regular therapy.
- Trial name
- METRONOME (NCT02810132)
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Aarhus University Hospital