Clinical trials: sponsored by Aarhus University Hospital
Coronary Artery Disease
Functional Assessment by Virtual Online Reconstruction. The FAVOR III Europe Trial
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is estimated based on two angiographic projections.
- Trial name
- NCT03729739
- Testing
- QFR-based diagnostic strategy, FFR-based diagnostic strategy
- Where
- 35 sites in Denmark, France and 9 more
- Volunteers
- 2,001 people
- Sponsor
- Aarhus University Hospital Skejby
Cancer-related Fatigue, Cancer-related Cognitive Impairment
Reducing Cancer Side-effects With Systematic Light Exposure
The main purpose of this interdisciplinary proposal is to conduct two randomized controlled trial (RCT) of the efficacy of self-administered systematic light exposure (Bright White Light (BWL)), an innovative, low cost, and low…
- Trial name
- LYS (NCT02661308)
- Testing
- Litebook
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Aarhus University Hospital
Breast Cancer, Fatigue
The Role of Circadian Rhythms in Cancer-Related Symptoms
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer…
- Conditions
- Breast Cancer, Fatigue, Cognitive Impairment, Sleep
- Trial name
- CHRONO (NCT04401189)
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Fear of Cancer Recurrence, Breast Cancer Female
ConquerFear-Group: A Psychological Intervention for Fear of Cancer Recurrence
The primary aim of this randomized controlled trial is to evaluate the effect of ConquerFear-Group (CF-G), compared with a control condition (CC), on Fear of Cancer Recurrence (FCR).
- Trial name
- NCT04137575
- Testing
- ConquerFear-Group, Relaxation Training
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Aarhus University Hospital
Knee Osteoarthritis
Allogenic Mesenchymal Stem Cell Intraarticular Injection for Knee Osteoarthritis Therapy
This phase I and II double blinded randomized clinical controlled trial investigates the safety and efficacy of intraarticular knee injection with allogenic adipose derived mesenchymal stem cells (AD-MSC), in patients suffering…
- Trial name
- STEMJOINT (NCT05933434)
- Testing
- Allogenic adipose derived mesenchymal stem cells (AD-MSC), Saline
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Aarhus University Hospital
Stress, Pain
Live Music in the Intensive Care Unit
The goal of this quasi-experimental pre- post test study is to test a patient-tailored live music intervention's effect on stress and pain reduction in adult, critically ill patients admitted to the intensive care unit.
- Trial name
- NCT06442644
- Testing
- Live music in the intensive care unit
- Where
- Denmark
- Volunteers
- 202 people
- Sponsor
- Aarhus University Hospital
Stroke, Ischemic, Device Related Thrombosis
APPEND-CT Registry
The APPEND-CT registry is an investigator-driven multicenter retrospective observational database intended to compile cardiac CT follow-up data after Watchman FLX device implantation and function as a platform for answering…
- Conditions
- Stroke, Ischemic, Device Related Thrombosis, Atrial Fibrillation
- Trial name
- APPEND-CT (NCT06213285)
- Testing
- Watchman FLX left atrial appendage occlusion
- Where
- 2 sites in United States, Denmark
- Volunteers
- 2,000 people
- Sponsor
- Aarhus University Hospital
Work Related Stress, Mental Health Issue
Impact of a Major Organizational Change on Employee Productivity and Mental Health
The study investigates the short- and long-term impact of a major organizational change on employee health and productivity. Changes in organizations is a common aspect of modern work life in all sectors and public healthcare is…
- Conditions
- Work Related Stress, Mental Health Issue, Work-related Illness
- Trial name
- PRO-MENTA (NCT06354335)
- Testing
- Employees exposed to a major hospital reorganisation
- Where
- Denmark
- Volunteers
- 31,555 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Heart Failure
Hemodynamic Effects of Modulating Circulating Ketone Bodies With 1,3-butanediol
Heart Failure (HF) is a major public health issue affecting 1-2% of the Western population and the lifetime risk of HF is 20%. Despite major improvements in the management and care of patients with HF, the 1-year mortality in…
- Trial name
- KETO-BD (NCT05768100)
- Testing
- 1,3-Butanediol
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Persistent Physical Symptoms
My Symptoms - Feasibility Study
The proposed project 'My Symptoms' is part of a large research programme: eHealth and GP-assisted self-help interventions for persistent physical symptoms (eASY). See www.minesymptomer.dk.
- Trial name
- NCT05287087
- Testing
- My Symptoms 1 (MySt-1), My Symptoms 2 (MySt-2)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital
Ischemic Stroke, Transient Ischemic Attack
Vascular Cognitive Decline and Dementia
The ENIGMA study is a single-centre prospective clinical observational study with the aim to investigate vascular contributions to cognitive decline and dementia.
- Trial name
- ENIGMA (NCT06257823)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Aarhus University Hospital
Sinus Node Disease, Atrial Fibrillation
Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome.
Atrial fibrillation (AF) is prevalent in patients with sick sinus syndrome (SSS) and associated with an increased risk of stroke and death.
- Trial name
- DANPACEII (NCT02034526)
- Testing
- DDDR-60, DDD-40
- Where
- Denmark
- Volunteers
- 540 people
- Sponsor
- Aarhus University Hospital
Anxiety State, Anxiety Disorders
Feasibility Test of the Treatment Program iACT-by Proxy - a Single Case Experimental Design
Health anxiety by proxy is defined as parents' obsessive worries about their child's health. It is a newly described phenomenon, where the parent has persistent and distressing fears that his or her child may suffer from a…
- Trial name
- NCT04830605
- Testing
- Internet-based treatment
- Where
- Denmark
- Volunteers
- 4 people
- Sponsor
- Aarhus University Hospital
Acute Lymphoblastic Leukemia, Post Thrombotic Syndrome
Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol
Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Today more than 90% of children and 75% of adults (18-45 years) survive ALL.
- Trial name
- NCT04825548
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Acute Lymphoblastic Leukemia
Pharmacokinetics and Immunogenicity of the First Doses of PEG-Asparaginase -An ALLTogether Pilot Study
Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Survival rates exceed 90% in children and 75% in adults (aged 18-45 years).
- Trial name
- NCT04843150
- Where
- 2 sites in Denmark
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Acute Lymphoblastic Leukemia
TDM of Asparaginase in ALL2008
Asparaginase is a cornerstone in the treatment of ALL. In most contemporary protocols like in NOPHO ALL2008 prolonged asparaginase treatment has been implemented.
- Trial name
- NCT04843514
- Where
- 2 sites in Denmark
- Volunteers
- 765 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Functional Disorder
Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder
The goal of this clinical trial is to test if patient education or duloxetine can be used to treat multisystem functional somatic disorder (FSD).
- Trial name
- EDULOX (NCT06232473)
- Testing
- Patient Education, Duloxetine, Enhanced usual care
- Where
- Denmark
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Giant Cell Arteritis, Polymyalgia Rheumatica
DANIsh VASculitis Database (DANIVAS)
The aim of this national pragmatic observational study is to investigate whether the use of new diagnostic imaging modalities facilitates disease stratification that can potentially predict treatment response, relapse risk and…
- Trial name
- DANIVAS (NCT05935709)
- Where
- 2 sites in Denmark
- Volunteers
- 3,000 people
- Sponsor
- Aarhus University Hospital
Acute Lymphoblastic Leukemia
Forecasting Hypersensitivity Against PEG-asparaginase to Optimize Outcome in ALL
Asparaginase is a cornerstone in the treatment of acute lymphoblastic leukemia (ALL). Clinical hypersensitivity reactions and PEG-asparaginase inactivation is common (12-13% of the patients on the NOPHO (Nordic Society for…
- Trial name
- NCT06195735
- Where
- Denmark
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Aortic Valve Stenosis
Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis
The objective of the present study is to investigate to hemodynamic profile at rest and during peak exercise of patients with suspected severe aortic stenosis and to compare flow- and pressure changes between high gradient…
- Trial name
- PREFLOW (NCT05580237)
- Testing
- Simultaneous right and left heart catheterization
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Aarhus University Hospital Skejby