Clinical trials: sponsored by Asan Medical Center
Heart Failure
Pilot Study on Withdrawal of Spironolactone Among Heart Failure With Improved Ejection Fraction
The study is a randomized controlled pilot trial to evaluate whether withdrawal of spironolactone is safe and associated with re-deterioration of left ventricular function in patients with heart failure with improved ejection…
- Trial name
- NCT04367051
- Testing
- Withdrawal of Spironolactone, Continuation of spironolactone
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Asan Medical Center
Bladder Cancer, Hematuria; Benign
PENK Methylation Test for Detecting Bladder Cancer
The primary objective of this clinical trial is to determine the sensitivity and specificity of the EarlyTect® Bladder Cancer test for bladder cancer among patients with hematuria by comparing it to the results of cystoscopy…
- Trial name
- NCT05220189
- Testing
- EarlyTect® Bladder Cancer test
- Where
- South Korea
- Volunteers
- 1,549 people
- Sponsor
- Asan Medical Center
Benign Ovarian Tumor
Efficacy Study of FloSeal in Hemostasis After Laparoscopic Ovarian Cystectomy
To compare the efficacy in postoperative hemostasis and in sparing postoperative ovarian function between FloSeal and Electrocauterization in laparoscopic ovarian cystectomy
- Trial name
- NCT01683877
- Testing
- FloSeal application, Electrocautery
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center
Advanced Rectal Cancer
Preoperative CRT With Capecitabine ± Temozolomide in Patients With LARC
This is a prospective biomarker-stratified, randomised phase II study of preoperative CRT with temozolomide plus capecitabine in patients with locally advanced rectal cancer.
- Trial name
- NCT03156036
- Testing
- Capecitabine plus temozolomide VS Capecitabine
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Asan Medical Center
Temperature Change, Body, Supraglottic Airway Device
Feasibility and Accuracy of Core Temperature Measurements Using the Esophageal Temperature Probe Inserted Through the Gastric Lumen of Supraglottic Airway Device in Pediatrics
In pediatric patients, the accuracy of body temperature measured with an esophageal temperature probe placed through the gastric lumen of the supraglottic airway device is investigated.
- Conditions
- Temperature Change, Body, Supraglottic Airway Device, Pediatric ALL
- Trial name
- NCT05705206
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Asan Medical Center
Periampullary Cancer, Borderline Malignancy Tumor
The Effect of ERAS on Pancreaticoduodenectomy (v2.0)
Enhanced Recovery After Surgery (ERAS) is not a program that aims to reduce postoperative hospital stay, but the multimodal strategies that aim to attenuate the loss of, and improve the restoration of, functional capacity after…
- Trial name
- NCT06009224
- Testing
- ERAS perioperative management
- Where
- South Korea
- Volunteers
- 334 people
- Sponsor
- Asan Medical Center
Surgery-Complications
Textbook and Survival Outcomes of MIPD in South Korea
The aim of this study was to investigate the current status of minimally invasive pancreatoduodenectomy (MIPD) in South Korea with regard to demographics, perioperative outcomes, risk factors for textbook outcome of pancreatic…
- Trial name
- NCT05975710
- Where
- South Korea
- Volunteers
- 1,552 people
- Sponsor
- Asan Medical Center
Graft Rejection, Heart Transplantation
Diagnostic Validity of [18F]FSPG PET for the Assessment of Acute Rejection After Heart or Liver Transplantation
The a series of clinical studies of [18F]FSPG PET/CT showed that [18F]FSPG is safe and promising PET tracer for detecting inflammation with favorable biodistribution and pharmacokinetics in patients.
- Conditions
- Graft Rejection, Heart Transplantation, Liver Transplantation
- Trial name
- NCT04488094
- Testing
- [18F]FSPG
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Asan Medical Center
Pheochromocytoma, Paraganglioma
F-18 FDOPA PET/CT Versus I-123 MIBG Scintigraphy With SPECT/CT for the Diagnosis of Pheochromocytoma and Paraganglioma
Pheochromocytomas and paragangliomas (PPGLs) are chromaffin cells-derived tomours that originate from the adrenal medulla (80~85%) and the extra-adrenal sympathetic paraganglia in thorax, abdomen and pelvis (15~20%) or…
- Trial name
- NCT05948137
- Testing
- F-18 FDOPA PET/CT
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Asan Medical Center
Acute Kidney Injury, Liver Diseases
Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation
Acute kidney injury (AKI) following liver transplantation (LT) is associated with increased costs, morbidity, and mortality. Dexmedetomidine has known to have anti-inflammatory effect and has been shown to ameliorate IRI in…
- Trial name
- NCT03522688
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Asan Medical Center
Pulmonary Rehabilitation, Cardiac Rehabilitation
Efficacy of Smartphone Application Based Rehabilitations in Patients With Chronic Respiratory or Cardiovascular Disease
In Republic of Korea, it is not easy to practice standard pulmonary rehabilitation (PR) or cardiac rehabilitation (CR). In this study, the investigators will provide newly developed smartphone application to patients with chronic…
- Trial name
- NCT05610358
- Testing
- smartphone application
- Where
- South Korea
- Volunteers
- 162 people
- Sponsor
- Asan Medical Center
Cervical Cancer, Endometrial Cancer
Development and Management of Registry in Patients With Gynecologic Cancer in Korea
The goal of this observational study is to identify and analyze the characteristics, treatment trends, prognostic factors and survival prognosis of Korean gynecologic cancer patients.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer, Fallopian Tube Cancer
- Trial name
- NCT05912972
- Testing
- Patient registry
- Where
- South Korea
- Volunteers
- 13,500 people
- Sponsor
- Asan Medical Center
Solid Tumors, Advanced Solid Tumors
A Phase II Stydy of Bevacizumab Plus Erlotinib in Patients for Krebs Cycle Altered Cancer
A national, prospective, multi-center, open-label, single arm phase II trial investigating the efficacy and safety of bevacizumab plus erlotinib in patients with advanced cancers which harbors genomic alterations in Krebs cycle
- Conditions
- Solid Tumors, Advanced Solid Tumors, Metastatic Cancer
- Trial name
- BRISK (NCT05904457)
- Testing
- bevacizumab, erlotinib
- Where
- 10 sites in South Korea
- Volunteers
- 32 people
- Sponsor
- Asan Medical Center
Postoperative Complications
Clinical Outcomes of Surgery After Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer
The purpose of this study was to investigate the clinical outcomes of patients with locally advanced pancreatic cancer (LA-PC) who underwent surgery after neoadjuvant chemotherapy (NACT) at Asan Medical Center's Department of…
- Trial name
- COSNALAP (NCT05888129)
- Testing
- surgery after neoadjuvant chemotherapy
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Asan Medical Center
Sedative
Median Effective Dose of Remimazolam for Sedation in Elderly Patients
Currently used drugs for monitored general anesthesia include propofol, midazolam, and dexmedetomidine. Each drug has different advantages and disadvantages.
- Trial name
- NCT05468996
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
COPD
Behavioral Interventions to Reduce Particulate Matter Exposure in Patients With COPD
It is a prospective, multi-institutional clinical study and targets patients diagnosed with chronic obstructive pulmonary disease.
- Trial name
- NCT04878367
- Testing
- Five active practices of living rules for responding to fine dust.
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Asan Medical Center
Functional Recovery, Laparoscopy
Comparison of Functional Recovery Between Laparoscopic and Open Pancreaticoduodenectomy
Laparoscopic surgery has not changed much in safety compared with open surgery through many existing studies, and has become a procedure to help patients' recovery.
- Conditions
- Functional Recovery, Laparoscopy, Periampullary Cancer
- Trial name
- NCT03870698
- Testing
- Laparoscopic group
- Where
- South Korea
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Epilepsy, Epilepsy in Children
Standardization of Anti-Seizure Medications Withdrawals After Seizure Remission in Young Patients With Epilepsy
The proper period of anti-seizure medication (ASM) treamtment is important for decreasing side effect of ASM and recurrence of seizure.
- Trial name
- ADORE (NCT05740423)
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Asan Medical Center
Hypertension, Hyperlipidemias
Mobile Application for Cardiovascular Risk Treatment
This study is a randomized, open-label clinical trial to validate the efficacy and safety of smartphone app-guided life style modification for the management of hypertension and hyperlipidemia.
- Conditions
- Hypertension, Hyperlipidemias, Chronic Disease, Lifestyle Risk Reduction
- Trial name
- iSMART-CV (NCT05712070)
- Testing
- App-guided lifestyle modification, A book-based self-education of lifestyle modification
- Volunteers
- 450 people
- Sponsor
- Asan Medical Center
Heart Failure
B-line by Lung US in Patients With Acute Decompensated Heart Failure
The purpose of this study is to evaluate that B-line detected by lung ultrasound before extubation in patients with acute decompensated heart failure can predict future risk of reintubation and clinical outcomes during admission…
- Trial name
- NCT04322851
- Testing
- Lung ultrasound
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center