Clinical trials: sponsored by Assistance Publique Hopitaux De Marseille
Brain Metastases, Diffuse Gliomas
Preclinical Brain Tumor Models
Background: Primary or secondary brain tumors (metastases) remain associated with a very poor prognosis linked to significant therapeutic resistance.
- Trial name
- HITCH (NCT06045065)
- Testing
- Fresh tumor sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Clostridioides Difficile Infection
Epidemiology of Clostridioides Difficile Infection (CDI) in Long-term Care Facilities, Assessment of Professional Practices Related to CDI Risk Prevention, and Strategies for Improving Care.
Clostridioides difficile infection (CDI) is the leading cause of infectious diarrhea among older adults. The epidemiology of community-acquired CDI, particularly among residents of long-term care facilities, remains poorly…
- Trial name
- EpiCE (NCT07920627)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Meningioma
Combination of Alpelisib and Trametinib in Progressive Refractory Meningiomas
Aggressive growing meningiomas resistant to multiple surgeries and radiotherapy constitute an unmet pharmaceutical need in neurooncology, leading to a fatal issue within a few months.
- Trial name
- ALTREM (NCT03631953)
- Testing
- Trametinib, Alpelisib, Blood sample
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Amyotrophic Lateral Sclerosis
Anticipated Patient and Caregiver Burden
Amyotrophic lateral sclerosis (ALS) is a degenerative neurological disease that causes progressive motor disability and is life threatening within a few years.
- Trial name
- FARP (NCT05632757)
- Testing
- Psychological assessments
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Very Premature Baby
Effects of a Multisensory Intervention Program on the Term Behavior of the Very Premature Baby
The growth and organization of the cerebral cortex is ensured by the oligodendrocyte-rich subplate, whose proper development depends on both subcortical structures and sensory experiences.
- Trial name
- PIVOT (NCT07903766)
- Testing
- Multisensory intervention program, Standard care
- Volunteers
- 144 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Charcot-Marie-Tooth Disease Type 1A
Tools for Therapeutic Evaluation in Charcot-Marie-Tooth Disease Type 1A: Outcome Measures and Biomarkers
This is a 2-year follow-up study of a cohort of 60 CMT1A patients. The objective is to identify markers allowing to better understand the phenotypic variability observed on patients with CMT1A, to identify predictive markers of…
- Trial name
- CMT-TOOLS (NCT02596191)
- Testing
- Clinical evaluation, electrophysiological record, Muscle MRI
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neurogenic Bladder Due to Spinal Dysraphism
EVALUATION OF THE SAFETY AND EFFICACY OF ADJUSTABLE CONTINENT THERAPY IN CHILDREN WITH SPINAL DYSRAPHISM.
Urinary continence is still a difficult goal to achieve in neurogenic bladder patients. Conservative treatment of neurogenic urinary incontinence using clean intermittent catheterization in conjunction with pharmacological…
- Trial name
- BPUA (NCT03351634)
- Testing
- Implantation of ACT balloon, Uromedica (Irvine, CA, USA) periurethrally at the bladder neck
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hematological Malignancy
Micro Assays for HemATology Malignancies Antibody Treatment
Hematological malignancy is a disease of the blood. In some cases, this pathology requires therapeutic management, which is not necessarily the case for you.
- Trial name
- MAHATMAt (NCT07018310)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 166 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Amyotrophic Lateral Sclerosis
New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. There is no treatment that significantly slows progression.
- Trial name
- IRM-SLA (NCT04691011)
- Testing
- Muscular MRI, Electrophysiological exam, Brain MRI
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Charcot-Marie-Tooth Neuropathy Type 1A, Hereditary Transthyretin Amyloid Neuropathy
Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients
The pathophysiological process common to neuropathies is fatty replacement of muscle tissue, more commonly known as intramuscular fat fraction (F.F).
- Conditions
- Charcot-Marie-Tooth Neuropathy Type 1A, Hereditary Transthyretin Amyloid Neuropathy, Acquired Demyelinating Neuropathy
- Trial name
- IMAGINERV (NCT06845644)
- Testing
- Quantitative neuromuscular MRI, Neuromuscular ultrasound
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Spinal Muscular Atrophy
Outcome Measures and Biomarkers in a Cohort of Spinal Muscular Atrophy Type III/ IV Patients
The "SMOB" project intends to contribute to fill the gap with reliable and operational outcome measures for type III and IV SMA.
- Trial name
- SMOB (NCT04690998)
- Testing
- Blood Samples, MRI
- Where
- 11 sites in France
- Volunteers
- 104 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Rare Genetic Muscle Diseases, Muscular Dystrophy, Duchenne
Transcriptomic Analysis to Put an End to Misdiagnosis in Patients With Rare Muscle Diseases
Since 2017, more than 250 analyses performed at the Molecular Genetics Laboratory of the Timone Enfant Hospital have yielded negative results in patients with rare genetic muscle diseases.
- Conditions
- Rare Genetic Muscle Diseases, Muscular Dystrophy, Duchenne, Muscular Dystrophy, Becker, Congenital Myopathy
- Trial name
- ARNseq-Musc (NCT06833489)
- Testing
- ARN extraction from muscle biopsies
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Rett Syndrome
Patients With RETT Syndrome
It was proposed to the French Association of Rett Syndrome (AFSR) to perform an extensive biological assessment in a series of 100 girls with Rett's syndrome and carriers of a mutation in the MECP2 gene in order to confirm or…
- Trial name
- RETT (NCT04014985)
- Testing
- An extensive biological assessment
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hepatic Cytolysis
Identification of Anti-HIF 1alpha Autoantibodies in Patients With Anorexia Nervosa and Characterization of Their Pathogenic Potential in Undernutrition-associated Hepatic Cytolysis
Anorexia nervosa (AN) is a psychiatric disorder belonging to the eating disorders (EDs). It is internationally recognized as a priority for improving health care.
- Trial name
- HIAM (NCT06869590)
- Testing
- blood sampling, blood sampling after 3-4 months
- Where
- France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Charcot-Marie-Tooth Disease Type 1A
Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease
This is a 2-year follow-up study of a cohort of 35 CMT1A patients and 20 healthy volunteers. The main objective is identifying prognostic markers for CMT1A using multi-omics analysis.
- Trial name
- CMT-MODS (NCT07049588)
- Testing
- Quantitative neuromuscular MRI, Skin biopsy, Clinical scores
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Naevi
Development of an Aid to Melanoma Detection Using Artificial Intelligence Algorithms Based on Images From the VECTRA 3D System.
The background to this research is that frequent medical screening of the general population for melanoma is not feasible. The real challenge of this project is to develop an automatic process for detecting any potential…
- Trial name
- SELF DETECT (NCT06999499)
- Testing
- Scanner of the whole body using the VECTRA 3D
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Solid Tumor Malignancies, Solid Cancers
Predicting Reactions and Effects of Drugs Immunotherapy and Complications Through Oncosafety (PREDICTO Clinical Study)
Immune Checkpoint Inhibitors (ICI) have revolutionized cancer therapy, providing unprecedented responses in a wide range of malignancies.
- Trial name
- PREDICTO (NCT07192315)
- Testing
- Bloodsampling, Pharyngeal swab sampling, Cuteanous swab sampling
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Myelodysplastic Syndromes (MDS), Leukemia Acute Myeloid - AML
Involvement of CDA and/or dCK Metabolizing Enzymes in the Response to Azacytidine Treatment of Patients With Hematologic Malignancies
Until now, the development of personalized medicine in oncology has relied on the use of somatic biomarkers to help therapists choose the right molecule(s) to administer, based on the genetic and molecular profile of each…
- Trial name
- CDA-AML-MDS (NCT06886425)
- Testing
- genetic study, Pharmacokinetic study, Study of phenotypic activity of cytidine deaminase
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Complex Congenital Heart Disease
Impact of Surgical Timing on the Neurodevelopmental Prognosis of Newborns With Complex Congenital Heart Disease
We propose a prospective observational study whose main objective will be to determine whether there is an association between age at surgery (days of life) and neurodevelopmental outcome in patients with CCHD.
- Trial name
- CINC (NCT04733378)
- Testing
- Peri-operative neurological monitoring
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Rasmussen Encephalitis
Study on Patients With Rasmussen Encephalitis Treated With Adalimumab: Efficacy and Tolerance in the Short and Long Term
Since the initial study of cases reported between 2009 and 2015, adalimumab has become in France the immunomodulatory reference treatment used after failure of corticosteroids and immunoglobulins before a possible recourse to the…
- Trial name
- NCT04003922
- Testing
- Adalimumab treatment
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille