Clinical trials: sponsored by Baylor Research Institute
Cardiovascular Abnormalities
Heartflow (AFFECTS)
The overall objective of the AFFECTS Study is to assess agreement between SPECT and FFRct in identifying vessel-specific, hemodynamically significant CAD in patients scheduled for invasive coronary angiography (ICA) based on…
- Trial name
- AFFECTS (NCT02973126)
- Testing
- FFRct and SPECT
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Baylor Research Institute
Hepatitis B
Safety and Efficacy of a Hepatitis B Vaccine in Immunosuppressed Patients
This is a preliminary trial of a Hepatitis B vaccine (Heplisav-B) in medically immunosuppressed patients. The purpose of this study is to test the ability of Heplisav-B to produce high levels of antibody that neutralize the virus…
- Trial name
- NCT04199715
- Testing
- Heplisav-B
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor Research Institute
Stroke, Hemiparesis
Effectiveness of Multichannel Functional Electrical Stimulation
The purpose of this pilot study is to determine whether two weeks of multi-channel FES along with task-specific training will improve UE function when compared to traditional rehabilitation or usual care.
- Trial name
- NCT04876703
- Testing
- Multichannel Functional electrical stimulation, Standard motor training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
ABPA, Severe Asthma
Benralizumab in the Treatment of Patients With Severe Asthma With ABPA
Phase IV, open-label study will evaluate effects of Benralizumab in the treatment of severe asthma in patients with allergic bronchopulmonary aspergillosis
- Conditions
- ABPA, Severe Asthma, Allergic Bronchopulmonary Aspergillosis
- Trial name
- NCT04108962
- Testing
- Fasenra, 30 Mg/mL Subcutaneous Solution
- Where
- United States
- Sponsor
- Baylor Research Institute
Breast Cancer
Safety Study Of Chemotherapy Combined With Dendritic Cell Vaccine to Treat Breast Cancer
The primary objective of this study is to determine the safety and feasibility of combining cyclin B1/WT-1/CEF (antigen)-loaded DC vaccination with preoperative chemotherapy.
- Trial name
- NCT02018458
- Testing
- LA TNBC: DC vaccine+Preop chemo, ER+/HER2-BC:DC vaccine+Preop chemo
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor Research Institute
Triple Negative Breast Cancer
Pilot Study To Investigate Targetable Metabolic Pathways Sustaining Triple Negative Breast Cancer
The primary objective is to describe and discover new insights into the glucose, amino acid, and lipid metabolic dependencies of TNBC via nuclear magnetic resonance (NMR) spectroscopy analysis of in vivo [1,2-13C] glucose-labeled…
- Trial name
- NCT03457779
- Testing
- Glucose
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Baylor Research Institute
Metastatic Breast Cancer
Safety and Blood Immune Cell Study of Anakinra Plus Physician's Chemotherapy Choice in Metastatic Breast Cancer Patients
To determine the safety of administering anakinra plus the physician's chemotherapy choice (TPC) of nab paclitaxel, capecitabine, eribulin, or vinorelbine in patients with metastatic breast cancer (MBC), as well as determining…
- Trial name
- NCT01802970
- Testing
- Anakinra plus Standard of Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor Research Institute
COVID-19
Hydroxychloroquine in the Prevention of COVID-19 Infection in Healthcare Workers
In order to assess the efficacy of hydroxychloroquine treatment weekly for a total of 7 weeks in the prevention of COVID-19 infection, three hundred sixty (360) Healthcare workers with high risk exposure to patients infected with…
- Trial name
- NCT04333225
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Law Enforcement Officers
Virtual Reality and tACS for Performance Enhancement
The chronic stress of police work may reduce human performance through increases in anxiety, depression, pain, and insomnia. Land's End VR may teach mindful meditation that is associated with reduced anxiety, depression, pain…
- Trial name
- NCT03636126
- Testing
- VR + TACS
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Pancreatic Adenocarcinoma
Gemcitabine, Nab-Paclitaxel, Cisplatin and Anakinra Treatment on Patients With Pancreatic Cancer
The objective of this study is to improve survival by the addition of anakinra to the chemotherapy combination of nab-paclitaxel, gemcitabine, and cisplatin in patients with resectable or potentially resectable pancreatic…
- Trial name
- NCT02550327
- Testing
- Nab-paclitaxel, Gemcitabine, Cisplatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Paroxysmal Atrial Fibrillation
Cryoballoon Pulmonary Vein Isolation Including Associated Esophageal Effects
To determine the correlation between rate of temperature decline and nadir cryoballoon temperatures rate of temperature decline and nadir esophageal temperatures during pulmonary vein isolation.
- Trial name
- NCT02998866
- Testing
- Esophageal Temperature-Guided Ablation
- Volunteers
- 1 people
- Sponsor
- Baylor Research Institute
Chronic Kidney Diseases, Cardiovascular Diseases
Cardiorenal Protective Diet
This study will evaluate providing fruits and vegetables in a sustainable community care clinic setting, in addition to routine medical care, to individuals with CKD (Stage 2-4) on CKD and CVD risk, or cardio-renal risk factors.
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Hypertension
- Trial name
- CPD (NCT04117204)
- Testing
- Fruits and Vegetables
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
CKD, ESRD
Reducing Chronic Kidney Disease Burden in an Underserved Population
To evaluate a scalable population health strategy to 1) screen, 2) identify, and 3) intervene with individuals at high risk of CKD progression to ESRD that could be implemented in other high risk communities and health care…
- Trial name
- NCT03832166
- Testing
- Fruits and Vegetables, Cooking
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Cirrhosis
Infections in Hospitalized Cirrhotic Patients
Hospitalized cirrhotic patients are at high risk of complications and adverse outcomes. This study aims to determine the current practice and outcomes in these following areas: 1. Community-acquired infections 2.
- Trial name
- NCT03137719
- Volunteers
- 385 people
- Sponsor
- Baylor Research Institute
Pain, Stress Incontinence, Female
Nitrous Oxide for Analgesia During Office Urethral Bulking
This study is designed to determine primarily if there is a difference in perceived pain in patients receiving urethral bulking with calcium hydroxylapatite using local lidocaine versus local lidocaine plus nitrous oxide gas.
- Trial name
- NCT03847922
- Testing
- Nitrous Oxide + Oxygen Gas (Product), lidocaine gel 2%, Room air
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baylor Research Institute
Aortic Stenosis
Non-contrast 3-dimensional Cardiac Magnetic Resonance Imaging
Non-contrast enhanced cardiac MRI using 3D whole heart acquisition protocol is non-inferior to contrast enhanced CT in the assessment of aortic annulus complex for pre-TAVR imaging.
- Trial name
- NCT04496297
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Baylor Research Institute
Weight Loss, Diabetic Gastroparesis
Potential Benefits of Sleeve Gastrectomy Surgery on Diabetic Gastroparesis Symptoms
The purpose of this registry is to evaluate if sleeve gastrectomy surgery will help with symptoms of delayed gastric emptying for patients suffering from diabetic gastroparesis.
- Conditions
- Weight Loss, Diabetic Gastroparesis, Bariatric Surgery Candidate, Sleeve Gastrectomy
- Trial name
- NCT03376399
- Testing
- Gastroparesis Cardinal Symptom Index Questionnaire
- Where
- United States
- Sponsor
- Baylor Research Institute
Acute Renal Failure
Acute Renal Failure Post Liver Transplantation
Trial to test the effect of administering N-acetylcysteine on cytokines and markers of oxidant stress and the incidence of acute renal failure post liver tranplant
- Trial name
- NCT01907061
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Hemodialysis, Peritoneal Dialysis
Alirocumab in Patients on a Stable Dialysis Regimen
12-week study of the efficacy and safety of alirocumab in patients maintained stably on hemodialysis or peritoneal dialysis. Measures of cholesterol levels, drug levels, PCSK9 levels, routine chemistry and cell counts, and…
- Conditions
- Hemodialysis, Peritoneal Dialysis, Hypercholesterolemia, Atherosclerotic Disease
- Trial name
- NCT03480568
- Testing
- Alirocumab 150 MG/ML [Praluent]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute