Clinical trials: sponsored by Beijing Tiantan Hospital
Glioma
Evaluate the Effectiveness and Safety of Raman IVD Analyzer in the Molecular Diagnosis of Gliomas During Surgery
To distinguish various molecular subtypes of gliomas by spectra data obtained from Raman analyzer, including IDH mutant, 1p/19q-codeleted, ATRX deletion, TERT promoter mutation, MGMT promoter methylation, EGFR amplification, H3…
- Trial name
- NCT06363162
- Testing
- Immunohistochemistry or genetic test
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal, Cognitive Dysfunction
Gamma Entrainment Stimulation for Cognitive Dysfunction After aSAH
The goal of this clinical trial is to Explore and verify whether 40Hz audio and binaural beat 40Hz audio can improve the postoperative cognitive dysfunction seen in patients with aneurysmal subarachnoid hemorrhage.
- Trial name
- GES-aSAH (NCT06346015)
- Testing
- Gamma Entrainment Stimulation
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative
Triamcinolone Acetonide as an Adjuvant to Pre-emptive Scalp Infiltration for Relief of Post-craniotomy Pain in Adults
Pain is common for the first 2 days after major craniotomy. A majority of patients would suffer from moderate-to-severe postoperative pain after undergoing craniotomy.
- Trial name
- NCT06069804
- Testing
- The TR group, The R group
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tiantan Hospital
Drug Resistant Epilepsy
Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy
The goal of the real-world study is to evaluate the long-term seizure control outcomes, postoperative complications, long term impact on cognitive, memory function outcomes, quality-of-life measures, and healthcare resource…
- Trial name
- NCT06341075
- Testing
- Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Vascular Occlusion
REperfusion Therapy for Acute Ischemic STrOke Due to Large aRtEry Occlusion
The aim of the study was to establish a clinical and advanced imaging database of acute ischemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion of anterior circulation within 24 hours from…
- Conditions
- Stroke, Vascular Occlusion, Endovascular Treatment, Mechanical Thrombectomy
- Trial name
- RESTORE (NCT05311605)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute
Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization
The goal of this clinical trial is to evaluate whether intra-arterial (IA) rhTNK-tPA thrombolysis can improve neurological outcomes in acute large vessel occlusion patients after successful mechanical thrombectomy (MT)…
- Trial name
- ANGEL-TNK (NCT05624190)
- Testing
- Recombinant Human tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA), Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
GD-11 for Injection in the Treatment of Acute Ischemic Stroke
Phase III Clinical Trial of GD-11 for Injection in the Treatment of Acute Ischemic Stroke - A Multi-Center, Randomized, Double-Blind, Parallel, Placebo-Controlled Phase III Clinical Study with the primary objective of evaluation…
- Trial name
- NCT06299579
- Testing
- GD-11 for injection test group
- Where
- 2 sites in China
- Volunteers
- 980 people
- Sponsor
- Beijing Tiantan Hospital
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Cerebral Vasospasm
At present, cerebral vasospasm (cVS) is the main cause of delayed cerebral infarction (DCI), which leads to high disability and mortality rate after aneurysmal subarachnoid hemorrhage.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Cerebral Vasospasm
- Trial name
- BLOCK-CVS (NCT04691271)
- Testing
- Stellate ganglion block
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Beijing Tiantan Hospital
Hemiplegia Following Ischemic Stroke
The Effectiveness of Rehabilitation Training Based on Brain-computer Interface Technology to Improve the Upper Limb Motor Function of Ischemic Stroke.
To evaluate the effectiveness and safety of rehabilitation training based on brain-computer interface in improving the upper motor function, self-care ability in daily life and quality of life in patients with ischemic stroke.
- Trial name
- REBUILT (NCT04387474)
- Testing
- Brain-computer interface, Traditional rehabilitation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Venous Thrombosis
Clinical Deterioration in Cerebral Venous Thrombosis: A Predictive Study
The objective of this retrospective, prospective, multicenter cohort study is to determine the risk factors for deterioration of CVT patients after admission and establish a scoring model for risk stratification of patients.
- Trial name
- NCT06266585
- Where
- China
- Volunteers
- 273 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
A Study Evaluating the Safety and Efficacy of Neuroprotective Peptide CN-105 Peptide in Patients With Acute Supratentorial Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular disease for which there are no approved therapeutics that improve outcomes.
- Trial name
- NCT06255977
- Testing
- CN-105
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Tiantan Hospital
Pituitary Adenoma
Application of Radiomics in the Diagnosis and Treatment Prediction of Pituitary Adenoma
The images of patients with Pituitary adenoma were collected and analyzed based on the methods of radiomics.
- Trial name
- RIPA (NCT06234553)
- Testing
- surgery of pituitary adenomas
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Brain Tumor Adult
Effects of Intravenous Anesthesia and Balanced Anesthesia on Flash Visual Evoked Potentials
Intraoperative flash visual evoked potentials (FVEPs) could monitor visual function during neurosurgery. There are fewer reports comparing the effects of sevoflurane-propofol balanced anesthesia and propofol-based total…
- Trial name
- NCT04725032
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Hemorrhage
Early Intensive Antihypertensive Treatment in High-Risk Population of intraCerebral Hemorrhage ExpanSion Predicted by Artificial Intelligence
The goal of this clinical trial is to clarify the efficacy, safety and feasibility of early intensive antihypertensive treantment in intracerebral hemorrhage (ICH) patients at high risk of hematoma expansion based on artificial…
- Trial name
- ARCHES (NCT06242938)
- Testing
- Early intensive antihypertensive treatment
- Volunteers
- 680 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Pain, Craniotomy
REDUCE Trial: Perineural Dexamethasone on Scalp Nerve Blocks
Pain is common in the first 2 days after major craniotomy. Inadequate analgesia may lead to an increased risk of postoperative complications.
- Conditions
- Postoperative Pain, Craniotomy, Dexamethasone, Scalp Nerve Blocks
- Trial name
- NCT04648358
- Testing
- Bupivacaine, Dexamethasone combined with bupivacaine
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Neurosurgery
Superficial Cervical Plexus Block for Postoperative Chronic Pain
The incidence of postoperative chronic pain after craniotomy is high. Postoperative chronic pain seriously affects patient's quality of life. Compound local scalp nerve block is a good choice for analgesia after craniotomy.
- Trial name
- NCT05108337
- Testing
- Superficial cervical plexus block, Control group
- Where
- 2 sites in China
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Postherpetic Neuralgia
Duloxetine for PHN
In this study, the investigators aim to investigate the preventive efficacy of prophylactic oral duloxetine during acute herpes zoster on postherpetic neuralgia and its safety.
- Trial name
- NCT04313335
- Testing
- Duloxetine
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Subdural Hematoma
YL-1 Needle Puncture vs BHC With Postoperative Exhaustive Drainage for CSDH
A prospective multicenter cohort study was designed to compare the differences in complications with YL-1 Needle Puncture versus Bulr-hole Craniotomy (BHC) with postoperative Exhaustive Drainage strategy for patients with Chronic…
- Trial name
- NEBULA (NCT06072053)
- Testing
- Burr Hole Craniostomy and Postoperative Exhaustive Drainage Strategy, YL-1 puncture needle and Postoperative Exhaustive Drainage Strategy
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Beijing Tiantan Hospital
Amyotrophic Lateral Sclerosis
Safety and Preliminary Efficacy of Aleeto in Amyotrophic Lateral Sclerosis
This study is a single-center, randomized, double-blind, placebo parallel-controlled, dose-escalation clinical study. The aim of this study was to evaluate the safety, tolerability, and preliminary effect of Aleeto in adult…
- Trial name
- SPECIALS (NCT06181526)
- Testing
- Aleeto, intravenous injection, intrathecal injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Tiantan Hospital
Aneurysmal Subarachnoid Hemorrhage
Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage
Rupture of intracranial aneurysms can lead to extensive subarachnoid hemorrhage (SAH), a potentially fatal neurological emergency with mortality rates ranging from 8 to 67%.
- Trial name
- LongTEAM (NCT04785976)
- Testing
- Surgical clipping and endovascular coiling
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Tiantan Hospital