Clinical trials: sponsored by Brown University
HIV/AIDS, Noncommunicable Diseases
Harambee: Integrated Community-based HIV/NCD Care & Microfinance Groups in Kenya
The objective of this project is to demonstrate the effectiveness and longer-term sustainability of a differentiated care delivery model for improving HIV treatment outcomes.
- Conditions
- HIV/AIDS, Noncommunicable Diseases, Hypertension, Diabetes
- Trial name
- NCT04417127
- Testing
- Integrated Community-Based (ICB) Care, Group-level Microfinance
- Where
- Kenya
- Volunteers
- 1,200 people
- Sponsor
- Brown University
Breast Neoplasms, Lung Neoplasms
Preventing Dato-DXd Associated Stomatitis With Dexamethasone Mouthwash, TROPION-DM
TROPION-DM/BrUOG-431 is a prospective, , phase 2 trial with two non-comparative cohorts analyzed jointly for primary endpoint in adult patients with either (Cohort 1:) advanced/metastatic hormone-receptor positive ([HR+]…
- Trial name
- NCT06974604
- Testing
- Dexamethasone oral
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brown University
HIV/AIDS
Brief Acceptance-Based Retention Intervention for Newly Diagnosed HIV Patients
The overall aim of this program of research is to test a newly developed intervention, Acceptance-Based Behavior Therapy (ABBT), to improve HIV patients' commitment to medical care.
- Trial name
- NCT04201288
- Testing
- Acceptance-Based Behavior Therapy (ABBT), Enhanced-Treatment-as-Usual (ETAU)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Brown University
Neurophysiologic Maturation
Neurophysiologic Maturation Index for Late Preterm Infants
Late preterm infants contribute to significant neonatal intensive care unit health care resource utilization because of their sheer numbers. Determinants of the length of hospitalization (LOH) in this population are understudied.
- Trial name
- NEMO Project (NCT02156817)
- Testing
- Amplitude integrated electroencephalogram, Cardiorespiratory signal acquisition
- Where
- 3 sites in United States, Canada
- Volunteers
- 26 people
- Sponsor
- Brown University
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Smoking, Cigarette, Electronic Cigarette Use
Dual Use of ENDS and Combustible Cigarettes
This study investigates the degree to which shared behavioral processes underlie combustible cigarette (CC) and electronic nicotine delivery system (ENDS) use in young adult dual users of these products in both the laboratory and…
- Trial name
- DUET (NCT05280535)
- Testing
- Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Dependence, Anxiety
Doxazosin an a1 Antagonist for Alcohol Dependence
Norepinephrine system represents an important treatment target for alcohol dependence (AD) and the α1 -blocker prazosin may reduce alcohol drinking in rodents and alcoholic patients.
- Trial name
- NCT01437046
- Testing
- Doxazosin
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Brown University
Multitasking Behavior and Neural Representations Associated With Multitasking Ability, Healthy Volunteers
Cognitive Control & the Functional Organization of the Frontal Cortex
The goal of this basic experimental clinical trial is to understand the effect of multitasking practice on the structure of neural representations of tasks in the human lateral prefrontal cortex and control brain regions.
- Conditions
- Multitasking Behavior and Neural Representations Associated With Multitasking Ability, Healthy Volunteers, Executive Function
- Trial name
- NCT06436209
- Testing
- Multitask Practice Intervention (MPI), Single-task Practice Intervention (SPI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brown University
Prostate Cancer, Adenocarcinoma of the Prostate
BrUOG 337: Olaparib Prior to Radical Prostatectomy For Advanced Prostate Cancer Defects in DNA Repair Genes
This study will evaluate approximately 3 months of treatment with the drug olaparib in patients with prostate cancer. A capsule formulation of olaparib (tradename Lynparza™) is approved by the United States Food and Drug…
- Trial name
- 337 (NCT03432897)
- Testing
- Olaparib Pill, Prostatectomy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brown University
Sexual Behavior, Depression
Our Family Our Future: Acceptability and Feasibility Study of a Family Prevention Program for HIV Risk and Depression
The purpose of this study is to assess the feasibility and acceptability of a family-based preventive intervention designed to reduce sexual risk behaviors and depressive symptoms among South African adolescents and their…
- Trial name
- NCT02432352
- Testing
- Our Family Our Future
- Where
- South Africa
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Brown University
Sexual Behavior, Intimate Partner Violence
Integrated Prevention of HIV Risk and Intimate Partner Violence Among Adolescents in South Africa
The purpose of this study is to test the feasibility and acceptability of Safe South Africa, an integrated intervention for preventing HIV and Intimate Partner Violence perpetration for male adolescents 15-17 years of age.
- Trial name
- NCT03179982
- Testing
- Safe South Africa
- Where
- South Africa
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Consumption, Unsafe Sex
Brief Interventions in the Emergency Department for Alcohol and HIV/Sexual Risk
This brief alcohol and sexual risk taking intervention has the potential to influence the public health by reducing alcohol use and sexual risk taking behavior in individuals who are seeking treatment in an Emergency Department.
- Trial name
- SAFER (NCT01351389)
- Testing
- Brief Motivational Intervention (BMI), Brief Advice
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Brown University
Prevention or Reduction of HIV Risk Behavior, Prevention or Reduction of Intimate Partner Violence
Schools Championing Safe South Africa
This study explores the acceptability and feasibility of a school-based intervention called Schools Championing Safe South Africa that engages teachers and students in an integrated approach for preventing risk behavior related…
- Trial name
- NCT05869864
- Testing
- Schools Championing Safe South Africa
- Where
- South Africa
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder
Enhancing the Effects of Alcohol Treatment With L-Carnitine
The primary objective of this study is to evaluate the effects of L-carnitine, 2.97g daily on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 4 weeks of daily dosing among participants ages 18-25…
- Trial name
- NCT05355311
- Testing
- L-carnitine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brown University
Alcohol Abuse, Alcohol Dependence
Motivational Interviewing for Alcohol-Positive Teens in the Emergency Room
The purpose of this study is to determine whether motivational interviewing is effective in reducing alcohol consumption and alcohol problems among young adults who present to an Emergency Room.
- Trial name
- NCT00246428
- Testing
- Individual Motivational Interview (IMI), Individual Motivational Interview + Family Check-Up
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Brown University
Alcoholism
Naltrexone, Craving, and Drinking
This 5-week study will examine the effects of naltrexone on alcohol craving, drinking rates, and reaction to drinking-related triggers, or cues, in participants' everyday environment and in laboratory sessions.
- Trial name
- NCT00006203
- Testing
- Naltrexone 50 Mg
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Brown University
Alcohol Use Disorder
Enhancing the Effects of Alcohol Treatment With Lamotrigine
This study will help determine the tolerability and efficacy of the mood-stabilizing anticonvulsant lamotrigine in youth with alcohol use disorder.
- Trial name
- NCT04770493
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brown University
Binge Drinking
Brief Alcohol Intervention for School-to-Work Transitions
This is a 2-year research project to test the efficacy of brief motivational intervention for reducing heavy alcohol use in young adults transitioning out of high school.
- Trial name
- NCT01546025
- Testing
- Brief Motivational Counseling, Relaxation training
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Brown University
Physical Inactivty, Physical Activity
Promoting Physical Activity and Healthy Eating in Latinas
The goal of this clinical trial is to learn if an Internet-based behavioral intervention can increase physical activity and improve diet quality among Latina adults.
- Conditions
- Physical Inactivty, Physical Activity, Diet Quality
- Trial name
- NCT06979297
- Testing
- Web-based physical activity and diet intervention, Wait-list control arm
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brown University