Clinical trials: sponsored by CHU de Reims
Hip Arthropathy, Hip Arthrosis
Superiority Randomized Controlled Trial of Ultrasound-guided PENG Block Compared to Surgical Infiltration in the Analgesia of Posterior Total Hip Arthroplasty Surgery
Pain after total hip replacement (THR) surgery is severe. The target population is elderly and comorbid. Level III analgesics are responsible for significant side effects in this population.
- Trial name
- PENGORINF (NCT06257160)
- Testing
- Surgical infiltration, PENG Block ultrasound-guided
- Where
- France
- Volunteers
- 224 people
- Sponsor
- CHU de Reims
Parental Anxiety Following Premature Birth
Impact of Preterm Birth on Symptoms of Anxiety and Depression in Parents, and on the Precursors of Cognition, Including Social Cognition in Their Child
In 2018, the World Health Organization (WHO) counted no less than 15 million preterm births each year worldwide, or more than one in ten children.
- Trial name
- PréDANPa (NCT05734768)
- Testing
- State-Trait Anxiety Inventory - Y ou STAI-Y
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Autoimmune Adverse Effects of Anti-neoplasic Drug
Autoantibodies Prevalence During Checkpoint Inhibitor Treatment
The use of Checkpoint inhibitors (ICIs) is rapidly expanding to the treatment of many cancer types. Autoimmunity and clinical autoimmune diseases represent adverse events of ICIs with variable severity and consequences.
- Trial name
- NCT04220034
- Testing
- Blood sample
- Where
- France
- Volunteers
- 183 people
- Sponsor
- CHU de Reims
Obstructive Sleep Apnea Syndrome
Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration.
- Trial name
- IRM SAOS (NCT05147649)
- Testing
- functional magnetic resonance imaging
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alzheimer Disease
Ability to Drive of Early Stage Alzheimer Disease
The main objectives of this study are: To evaluate the driving capacities in a population of elderly subjects with early stage Alzheimer Disease (AD) in a real-life situation.
- Trial name
- DRIVE COG (NCT01566071)
- Testing
- Assessment of drive abilities
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Antiphospholipid Syndrome
Prevalence and Consequences of Antiphospholipid Syndrome in Patients Aged 65 and Over With Ischemic Strokes (IS)
Stroke represents a major cause of morbidity and mortality despite significant progress in recent decades. In individuals under the age of 65, the etiologies of ischemic stroke (IS) are diverse, and management is…
- Trial name
- SAPLAGE (NCT07163338)
- Testing
- Collectio nof blood
- Where
- France
- Volunteers
- 400 people
- Sponsor
- CHU de Reims
Renal Insufficiency
Comparison of HYDROLINK™ and HeprAN™ mEmbranes in a Per Dialytic Heparin Weaning Strategy in Chronic Hemodialysis Patients
Chronic kidney disease (CKD) results from the progressive and irreversible destruction of the kidneys. As of December 31, 2018, there were 89,692 people in France undergoing replacement therapy, including 49,271 (55%) on dialysis…
- Trial name
- RESTIT (NCT05117450)
- Testing
- Decrease per-dialytic heparin therapy
- Where
- France
- Volunteers
- 302 people
- Sponsor
- CHU de Reims
Pediatric Epilepsy
Social Cognition in Pediatric Epilepsy
The purpose of this study is to investigate the development of social cognition skills in pediatric epilepsy compared to healthy children.
- Trial name
- TOMEPI (NCT04253379)
- Testing
- Neuropsychological evaluation , Evaluation of theory of mind, Evaluation of executive functions, Evaluation of verbal skills
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Polycystic Ovary Syndrome Health-related Quality of Life
Translation and Validation of the French mPCOSQ (mPCOSQ-F).
This study is a prospective, observational, bicentric study, evaluating the validity and reliability of a French version of the mPCOSQ questionnaire (mPCOSQ-F), used to assess health-related quality of life (HRQOL) in women with…
- Trial name
- NCT07016035
- Testing
- mPCOSQ-F and SF-36
- Where
- France
- Volunteers
- 350 people
- Sponsor
- CHU de Reims
Diabetic Retinopathy
Performance of the Electroretinogram, Performed and Interpreted by an Advanced Practice Nurse, in the Screening for Diabetic Retinopathy.
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and the leading cause of preventable blindness in working-age individuals. Early screening for DR is a public health issue.
- Trial name
- ERGDIAB (NCT06782997)
- Testing
- Electroretinogram
- Where
- France
- Volunteers
- 270 people
- Sponsor
- CHU de Reims
General Critically Ill Patients With Hypovolemia
Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Mechanically Ventilated Patients Under Spontaneous Mode
The management of septic shock patients includes the infusion of fluids, however fluids may be deleterious if the patient does not respond by increasing cardiac output.
- Trial name
- NCT06495489
- Testing
- Detection of preload responders by a PLR test
- Where
- France
- Volunteers
- 34 people
- Sponsor
- CHU de Reims
Corneal Dystrophy
Microsurgical Robot-assisted Corneal Transplant
Full-thickness corneal grafting (transfixing keratoplasty) is a tissue graft described at the beginning of the 20th century, which has remained technically unchanged for several decades.
- Trial name
- GRACE (NCT06844123)
- Testing
- Robot-assisted keratoplasty
- Where
- France
- Volunteers
- 10 people
- Sponsor
- CHU de Reims
Elderly
Anticipating and Tracking: Pack of Gerontological Assessment Embedded
ARPEGE project fits within the general framework of maintaining functional autonomy in the frail elderly. The early identification of elderly people at risk of frailty is essential to be able to make corrective actions to…
- Trial name
- ARPEGE (NCT02818439)
- Testing
- evaluation of frailty
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Inflammatory Bowel Diseases, Crohn Disease
Prevalence and Factors Associated With Sleep Disorders in Inflammatory Bowel Disease
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), are an inflammatory disease that can affect the entire digestive tract from the mouth to the anus for CD and the entire colon and…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Sleep Disorder
- Trial name
- SOMMICI (NCT06439641)
- Testing
- Ulcerative colitis Disease Activity Index
- Where
- France
- Volunteers
- 300 people
- Sponsor
- CHU de Reims
Periodontitis, Gingivitis
Intraoral Scanners as a Motivation Method for Oral Hygiene Instruction
Periodontal diseases are highly prevalent inflammatory diseases. These diseases are mostly due to the development and the maturation of bacterial plaque which lead to local inflammation.
- Trial name
- Perio3D (NCT05079204)
- Testing
- Intra oral scan, No intervention
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Chronic Inflammatory Pulmonary Diseases
Cohort for Research and Innovation in Chronic Inflammatory Respiratory Diseases
Chronic inflammatory pulmonary diseases including chronic obstructive pulmonary disease (COPD), interstitial lung diseases (ILD), bronchiectasis, and cystic fibrosis (CF) are characterized by lung inflammation and remodelling.
- Trial name
- RINNOPARI (NCT02924818)
- Testing
- Clinical assessment, questionnaires, pulmonary function test
- Where
- France
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Pain
Comparison of the Clinical Efficacy of 2 Paravertebral Block Strategies in Thoracic Surgery by Thoracotomy: by the Anesthetist (Paravertebral Block Guided by Ultrasound) and by the Thoracic Surgeon (Paravertebral Block Visual)
Post-thoracotomy pain is one of the most severe. The local analgesia allows its effective control and a reduction of postoperative morbidity and mortality. The gold standard for local analgesia is the thoracic epidural.
- Trial name
- PVBS-USguided (NCT02865226)
- Testing
- paravertebral block by the anesthetist before incision (paravertebral block guided by ultrasound), paravertebral block by the thoracic surgeon at chest closure (paravertebral block visual).
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Chronic Kidney Insufficiencies
Influence of Socio-aesthetic Care on the Quality of Life of Hemodialysis Patients
The report of the Epidemiological and Information Network in Nephrology counted 44,978 hemodialysis patients in France in 2017, with more than 93% of them attending 3 sessions per week.
- Trial name
- SocioAesthetic (NCT05000073)
- Testing
- dialysis and socio-aesthetic care, dialysis
- Where
- France
- Volunteers
- 161 people
- Sponsor
- CHU de Reims
Intensive Care Units, Family's Satisfaction
Withholding or Withdrawing of Life-sustaining Therapy in Great East French Region Intensive Care Units: a 1-month Survey
Intensive care has known an important scientists progress for the last twenty years, allowing to heal more and more severe patients.
- Conditions
- Intensive Care Units, Family's Satisfaction, Therapy Decisions
- Trial name
- LATA (NCT05465187)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 78 people
- Sponsor
- CHU de Reims
Spinal Anesthesia
Impact of Listening to Music on Anxiety Postoperative in a Postanesthesic Care Unit (PACU) After Spinal Anesthesia
Our hypothesis is that listening to music has a beneficial effect on the French population receiving spinal anesthesia for a scheduled procedure.
- Trial name
- MusicAnx-SSPI (NCT05002257)
- Testing
- music therapy, No music therapy
- Where
- France
- Volunteers
- 123 people
- Sponsor
- CHU de Reims