Clinical trials: sponsored by Changhai Hospital
Chronic Pancreatitis
Establishment of Clinical Staging of Chronic Pancreatitis Based on Histopathology of Pancreatic Duct Biopsy
This study intends to establish the clinical staging of chronic pancreatitis based on histopathology through pancreatic duct biopsy technology.
- Trial name
- NCT05352932
- Testing
- pancreatic duct biopsy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Colorectal Cancer, Precancerous Lesion
Study on the Diagnostic Value of Multi-omics Combined Detection for Precancerous Lesions of CRC
Colorectal cancer (CRC) has become one of the most common malignant tumors in the world, and the key to its prevention and control is early detection and treatment.
- Conditions
- Colorectal Cancer, Precancerous Lesion, Inflammatory Bowel Diseases
- Trial name
- NCT05530746
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Endoscopic Retrograde Cholangiopancreatography, Klatskin Tumor
Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures
The purpose of this study is to evaluate application value of the endoscopic cutting technique in the treatment of malignant hilar biliary strictures.
- Trial name
- ENBD (NCT03353181)
- Testing
- Endoscopic scissors, Biliary stent
- Where
- China
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Fatigue, Psychological Comorbidity and Quality of Life Among Patients With Chronic Pancreatitis in China.
This study will investigate the status of fatigue, psychological comorbidity and quality of life among patients with chronic pancreatitis in China and analyze their influencing factors.
- Trial name
- NCT05489003
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Changhai Hospital
Department of Anorectal Surgery, Changhai Hospital Affiliated to Naval Medical University
A Randomized, Controlled, Multicenter, Noninferiority Clinical Study of Perioperative and Oncological Safety in Patients With Rectal Cancer
Laparoscopic natural orifice specimen extraction surgery (NOSES) for low rectal cancer has a good minimally invasive effect. However, the NOSES prognosis studies are all small sample retrospective studies.
- Trial name
- NCT05503381
- Testing
- Laparoscopic radical resection of low rectal cancer with transanal specimens
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
Treatment
Stereotactic Body Radiotherapy (SBRT) for Oligometastatic Prostate Cancer
The aim of this study is to test the safety and feasibility of SBRT without ADT in oligometastatic prostate cancer in patients for whom the standard treatment is ADT, and to further explore how long only radiotherapy for…
- Trial name
- NCT04599686
- Testing
- ADT, SBRT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Cancer
iDentification and vAlidation Model of Liquid biopsY Based cfDNA Methylation and pRotEin biomArKers for Pancreatic Cancer (DAYBREAK Study)
DAYBREAK is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, serum protein markers, blood miRNA markers and others, in which of 450…
- Trial name
- NCT05495685
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Advanced Pancreatic Cancer
Organoid-Guided Chemotherapy for Advanced Pancreatic Cancer
The purpose of this study is to explore whether chemotherapy regimens guided by organoid drug sensitivity test can improve the outcomes of advanced pancreatic cancer.
- Trial name
- NCT04931381
- Testing
- Chemotherapy guided by organoid drug sensitivity test
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Bowel Preparation for Colonoscopy
Efficacy and Safety of Oral Sulfate Solution on Bowel Preparation for Colonoscopy
To evaluate whether oral sulfate solution used for colon cleaning in adults prior to colonoscopy was not inferior to 3-liter polyethylene glycol in the proportion of subjects with BBPS score (total colon) ≥6 after colonoscopy
- Trial name
- NCT05465889
- Testing
- Oral sulfate solution (OSS), Polyethylene Glycol Electrolyte
- Where
- China
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Esophageal Diseases
Detachable String Magnetically Controlled Capsule Endoscopy for Follow-up of Patients With Esophageal Diseases
The purpose of the study is to determine the accuracy of detachable string magnetically controlled capsule endoscopy(DS-MCE) as a follow-up method for patients with previous esophageal diseases.
- Trial name
- NCT05469152
- Testing
- ds-MCE and EGD
- Where
- 7 sites in China
- Volunteers
- 310 people
- Sponsor
- Changhai Hospital
Breast Neoplasms, Treatment
Classified Treatment Strategy for De-novo Metastatic Breast Cancer After Systemic Adjuvant Therapy
For patients with de novo stage IV breast cancer, the current debate is whether local surgery can improve the survival of patients.
- Conditions
- Breast Neoplasms, Treatment, Metastatic Breast Cancer, Survival
- Trial name
- CS (NCT05285332)
- Testing
- surgical treatment 1, surgical treatment 2, Systemic therapy
- Volunteers
- 362 people
- Sponsor
- Changhai Hospital
Obesity
Magnetically Controlled Capsule Endoscope System in Stomach Examination of Moderately and Severely Obese Patients
This study is a prospective, multicenter clinical trial. The study is planned to be conducted at a qualified clinical trial center, and 30 subjects are planned to be enrolled to evaluate the feasibility and safety of magnetically…
- Trial name
- NCT05459714
- Testing
- MCE for obese patients
- Where
- 3 sites in China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Colorectal Cancer, Colorectal Neoplasm
A Stool DNA Test for Detection of Advanced Colorectal Neoplasia in Asymptomatic Chinese Community Population
to determine screening value of stool-based SDC2 DNA methylation test for advanced colorectal neoplasia in the asymptomatic Chinese community population.
- Conditions
- Colorectal Cancer, Colorectal Neoplasm, Advanced Adenoma, Adenoma
- Trial name
- NCT04786704
- Testing
- Stool-based SDC2 DNA methylation test, quantitative Fecal immunochemical test
- Where
- China
- Volunteers
- 12,106 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Parkinson Disease
Effect of Scalp Nerve Block on the Recovery Quality of Parkinson's Patients After Deep Brain Stimulation
Patients diagnosed with Parkinson's disease (PD) undergoing deep Brain Stimulation (DBS) have a higher risk of perioperative complications and postoperative pain will affect quality of recovery (QoR) resulting in longer…
- Trial name
- NCT05353764
- Testing
- scalp nerve block combined with intercostal nerve block using 0.5% ropivacaine
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Changhai Hospital
Gastroscopy, Feelings
Improve the Comfort, Safety and Quality of Upper Endoscopy by a Modified Fasting Protocol
This double-center, prospective, interventional study aims to include 200 gastroscopic procedures and investigate the relationship between fasting time and feeling of subjects.
- Conditions
- Gastroscopy, Feelings, Fasting
- Trial name
- NCT05219136
- Testing
- Modified Fasting Group, Conventional Fasting Group
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Pancreatitis
Rectal Indomethacin to Prevent Post ESWL-pancreatitis
The purpose of the study is to determine whether rectal indomethacin reduces the incidence of post-ESWL pancreatitis.
- Trial name
- RIPEP (NCT02797067)
- Testing
- indomethacin suppository, Glycerin Suppository
- Where
- China
- Volunteers
- 1,370 people
- Sponsor
- Changhai Hospital
Prostate Cancer, Urinary Incontinence
An RCT to Compare Early Continence Recovery After RARP With or Without Sustainable Functional Urethral Reconstruction
The study is a prospective randomized controlled trail to compare early urinary continence recovery after robotic-assisted radical prostatectomy with or without sustainable functional urethral reconstruction (SFUR).
- Trial name
- NCT04037800
- Testing
- SFUR-RARP, Standard RARP
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
SBRT Plus Pembrolizumab and Trametinib for Pancreatic Cancer
Hypothesis: Survival benefits could be found in SBRT Plus Pembrolizumab and Trametinib compared with SBRT plus gemcitabine.
- Trial name
- NCT02704156
- Testing
- Cyberknife plus Pembrolizumab and Trametinib, Cyberknife plus Gemcitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Changhai Hospital
Gastroscopy Time, Early Gastric Cancer
Setting the Shortest Examination Time of Gastroscopy to Improve the Detection Rate of Upper Gastrointestinal Tumors
This multicenter, prospective, interventional study aims to include 2000 gastroscopic procedures and investigate the relationship between procedure time and lesion detection rate in tertiary endoscopic centers in China.
- Conditions
- Gastroscopy Time, Early Gastric Cancer, Detection Rate
- Trial name
- NCT04602299
- Testing
- Set the minimum time of gastroscopy
- Where
- 2 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer, Metastatic Liver Cancer
Anti-CEA CAR-T Cells to Treat Colorectal Liver Metastases
Recurrence of liver metastasis in colorectal cancer after R0 resection is mainly due to the invisible minimal residual disease, which are the main factors leading to metastasis and recurrence.
- Trial name
- NCT05240950
- Testing
- Anti-CEA CAR-T Cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Changhai Hospital