Clinical trials: sponsored by Changhai Hospital
Colonic Polyps, Colorectal Adenomas
Impact of Automatic Polyp Detection System on Adenoma Detection Rate
In recent years, with the continuous development of artificial intelligence, automatic polyp detection systems have shown its potential in increasing the colorectal lesions.
- Trial name
- NCT03967756
- Testing
- Automatic polyp detection system
- Where
- China
- Volunteers
- 1,118 people
- Sponsor
- Changhai Hospital
Chronic HBV Infection, Drug Withdrawal
Serum HBV RNA Value on Chronic Hepatitis B Virus Infection Manage
As an alternative biomarker of intrahepatic covalently closed circular DNA(cccDNA) transcriptional activity, hepatitis B virus(HBV)RNA may evolve during long-lasting virus-host interactionsduring chronic hepatitis B viral…
- Trial name
- NCT03909191
- Testing
- serum HBV RNA
- Volunteers
- 454 people
- Sponsor
- Changhai Hospital
High Risk Population of Gastric Cancer
Application of OE in Diagnosis of EGC
The main purpose of this study is to evaluate application value of OE mode 2 in the diagnosis of early gastric cancer The Secondary purpose is to evaluate application value of OE mode 1 in differentiating the diagnosis of…
- Trial name
- NCT04720521
- Testing
- OE+white light
- Where
- China
- Volunteers
- 2,454 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Functional Constipation, Gastrointestinal Disease
Efficacy and Safety of Vibrating Capsule in Patients With Functional Constipation
The safety and efficacy of vibrating capsule (VC) in promoting defecation by mechanical stimulation of the gastrointestinal walls have been elucidated in animal studies and pilot clinical studies.
- Conditions
- Functional Constipation, Gastrointestinal Disease, Capsule Endoscopy
- Trial name
- NCT04671264
- Testing
- Sallowing VC during six weeks
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Acute Pancreatitis
Relationship of CP and AP
The present study aimed to determine the prevalence of AP attacks before the diagnosis of CP and further identified the potential associated factors for AP episodes.
- Trial name
- NCT04670705
- Testing
- patients' characteristics
- Volunteers
- 1,022 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Treatment Strategy of Pancreatic Radiolucent Stone
Treatment strategy of chronic pancreatitis (CP) patients with large pancreatic radiolucent stone (≥ 5mm) has not been established.
- Trial name
- NCT04628273
- Testing
- encoscopic retrograde cholangio-pancreatography, extracorporeal shock wave lithotripsy
- Volunteers
- 52 people
- Sponsor
- Changhai Hospital
Tricuspid Valve Insufficiency
THE TRAVEL TRIAL: Transcatheter Right Atrial-ventricular Valve rEplacement With LuX-Valve
The trial aims to evaluate the safety and effectiveness of LuX-Valve transcatheter tricuspid valve and delivery system which are intended to use in symptomatic patients with severe tricuspid regurgitation and high surgical risk.
- Trial name
- TRAVEL (NCT04436653)
- Testing
- Tricuspid Valve Replacement System
- Where
- 8 sites in China
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Risk Factors
Risk Factors for Post-ESWL and Post-ERCP Pancreatitis
The study aimed to identify risk factors for post-ERCP pancreatitis(PEP) after ESWL, and the relationship between the occurrence of post-ESWL pancreatitis and PEP.
- Conditions
- Chronic Pancreatitis, Risk Factors, ERCP, ESWL
- Trial name
- NCT04619511
- Volunteers
- 714 people
- Sponsor
- Changhai Hospital
Capsule Endoscopy
The Second-Generation MCCG for Upper Gastrointestinal Tract.
The aim of this study is to evaluate the clinical application of the second-generation MCCG with higher image resolution and frame rate for upper gastrointestinal tract compared with the first-generation.
- Trial name
- NCT03977935
- Testing
- the second-generation MCCG
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Treatment
Integrated Boost to the Dominant Intraprostatic Nodule Based on Ga-68 PSMA PET/MR Study of SBRT With Prostate Cancer
The aim of this study is to test the safety and efficacy of integrated boost to the dominant intraprostatic nodule based on Ga-68 Prostate-Specific Membrane Antigen (PSMA) PET/MR in Stereotactic Body Radiation Therapy (SBRT) in…
- Trial name
- SBRT (NCT04599699)
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Combination of SBRT With Sequential S-1 for Treating Locally Advanced Pancreatic Cancer
The safety and efficacy of combination of SBRT with sequential S-1 in treating patients with locally advanced pancreatic cancer and poor medical conditions will be evaluated.
- Trial name
- NCT02704143
- Testing
- combination of Cyberknife with S-1
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Changhai Hospital
Endoscopic Ultrasonography, Sedation
End-Tidal Carbon Dioxide Monitoring Device for Sedation During Endoscopic Ultrasonography
To meet the needs of both operators and patients, moderate and deep sedation has been widely used in digestive endoscopy, which is invasive and painful. With its pleasant effects, sedation has complications nevertheless.
- Conditions
- Endoscopic Ultrasonography, Sedation, Monitoring
- Trial name
- NCT04549623
- Testing
- Novel end-tidal CO2 monitoring device, SpO2 and respiratory motion monitoring
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Changhai Hospital
Melena
Magnetically Controlled Capsule Endoscopy First vs. Standard Algorithm in Patients With Melena
MCE first algorithm is not inferior to standard of care algorithm in terms of further bleeding in hemodynamically stable patients with acute overt and non-hematochezia GI bleeding.
- Trial name
- FIRM (NCT04019067)
- Testing
- MCE first
- Sponsor
- Changhai Hospital
Colorectal Neoplasms, Colonic Polyp
Adenoma Detection Rate Using Endocuff Vision in China
The primary aim of this study is to explore the usefulness of Endocuff Vision in colonoscopy on adenoma detection rate (ADR). Other aims include to explore the data below when Endocuff Vision is used.
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma
- Trial name
- SinoEVADR (NCT03839277)
- Testing
- Endocuff Vision
- Where
- 5 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Neoplasms, Colonic Polyp
Adenoma Detection Rate Using AI System in China
The primary aim of this study is to explore the usefulness of Artificial Intelligence system in colonoscopy on adenoma detection rate (ADR). Other aims include to explore the data below when Artificial Intelligence is used.
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma
- Trial name
- SinoAIADR (NCT03840590)
- Testing
- CSK AI system, Standard Colonoscopy
- Where
- 4 sites in China
- Volunteers
- 743 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Robotic Surgical Procedures, Prostatectomy
MicroPort® Endoscopic Instrument Control System to Accomplish Robotic-assisted Surgery in Urology
Laparoscopy, now virtually completely, was replaced with robotic surgery in uro-oncological surgery in the world. And given the significant increase in the number of robotic surgeries for prostate, bladder and kidney cancer, it…
- Conditions
- Robotic Surgical Procedures, Prostatectomy, Nephrectomy
- Trial name
- MARS (NCT04404738)
- Testing
- MicroPort® robot-assisted laparoscopic surgery, da Vinci robot-assisted laparoscopic surgery
- Where
- 4 sites in China
- Volunteers
- 104 people
- Sponsor
- Changhai Hospital
Subarachnoid Hemorrhage, Aneurysmal
Efficacy and Safety of Bivalirudin Versus Heparin During Coil Embolization in Patients With Ruptured Intracranial Aneurysms
This is a randomized, open label, multi-center, positive-controlled study, in which a total of 236 patients will be enrolled and randomly assigned to receive bivalirudin or heparin in a 1:1 ratio during coil embolization in…
- Trial name
- BUILD (NCT04532333)
- Testing
- Bivalirudin 250 MG Injection, Heparin
- Volunteers
- 236 people
- Sponsor
- Changhai Hospital
Familial Adenomatous Polyposis
Colorectal Adenoma Canceration in FAP
The current internationally accepted treatment method for familial adenomatous polyposis is prophylactic total colorectal resection combined with endoscopic follow-up.
- Trial name
- NCT04531930
- Testing
- surgery, enhanced colonoscopy, self choosed methods
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Changhai Hospital
Colorectal Neoplasm, Colorectal Cancer
Colorectal Cancer Screening Using Stool DNA-based SDC2 and SFRP2 Methylation Test in China
The primary objective is to determine sensitivity, specificity, positive predictive value and negative predictive value of a bi-target stool DNA testing (the methylation status of SDC2 and SFRP2) for colorectal cancer and…
- Conditions
- Colorectal Neoplasm, Colorectal Cancer, Adenomatous Polyps, Adenoma
- Trial name
- NCT04515082
- Testing
- Stool-based SDC2 and SFRP2 DNA methylation test, FIT
- Volunteers
- 4,800 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Training Endoscopists to Perform On-site Rapid Cytological Evaluation for EUS-FNA of Solid Pancreatic Lesions
In China, there is a serious shortage of pathologists who can perform on-site cytological diagnosis. As a result, there are few centers that can conduct ROSE in China, which limits the diagnostic accuracy of EUS-FNA to a certain…
- Trial name
- EUS-FNA (NCT04509687)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital