Clinical trials: sponsored by Changhai Hospital
UTUC, UC (Urothelial Cancer)
A Comparative Study of Neoadjuvant Chemotherapy Versus Upfront Radical Surgery for Upper Tract Urothelial Carcinoma
This is a single-center, open-label, non-randomized controlled trial comparing the efficacy and safety of neoadjuvant chemotherapy (NAC) followed by radical surgery versus upfront radical surgery alone in patients with high-risk…
- Trial name
- NCT07155044
- Testing
- NAC
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Acute Pancreatitis, Severe Acute Pancreatitis
Fecal Microbiota Transplantation (FMT) in Patients With Moderate to Severe Acute Pancreatitis
This study is a randomized, double-blind and placebo-controlled study. The purpose of this study is to evaluate the efficacy and safety of FMT in patients with moderate to severe acute pancreatitis.
- Trial name
- NCT07153809
- Testing
- FMT
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Changhai Hospital
Autoimmune Diseases
An Exploratory Clinical Study of CD19 CAR NK Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
A single arm, open-label pilot study is designed to determine the safety and effectiveness of CD19 CAR NK cells in patients with autoimmune diseases. 36-72 patients are planned to be enrolled in the dose-escalation trial.
- Trial name
- NCT06464679
- Testing
- anti-CD19 CAR NK cells
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Changhai Hospital
Rectal Cancer
Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer
This is a multicenter, prospective, randomized phase II trial designed to evaluate the efficacy and safety of short-course neoadjuvant chemoradiotherapy combined with the PD-1 monoclonal antibody serplulimab and the…
- Trial name
- NCT07134218
- Testing
- serplulimab、bevacizumab, neoadjuvant chemoradiation therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm
Artificial Intelligence-powered Low-Dose Computed Tomography for Screening of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with early diagnosis crucial for improving survival. Due to the absence of effective screening methods, most patients are diagnosed at advanced stages.
- Conditions
- Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, High-grade Pancreatic Intraepithelial Neoplasia, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- AI-LDCT-PC (NCT07117045)
- Testing
- Diagnostic Evaluation for Positive AI Findings
- Where
- 5 sites in China
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery
Perioperative Blood Transfusion and Increased One-year Mortality
The goal of this retrospective observational study is to explore the association of perioperative blood transfusion with increased one-year mortality in patients undergoing surgeries.
- Trial name
- NCT07094295
- Testing
- perioperative blood transfusion
- Volunteers
- 97,443 people
- Sponsor
- Changhai Hospital
Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia
Comparison of the Sensitivity of pCLE and Pathological Biopsy Before ESD
Pathological biopsy before endoscopic submucosal dissection (ESD) the gastric lesion plays an important role in differentiating the pathological nature of the lesion and guiding treatment decisions.
- Conditions
- Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia, Gastric Low-grade Intraepithelial Neoplasia, Gastritis
- Trial name
- NCT07088744
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- 4 sites in China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Chronic Hepatitis b
HBV-Specific TCR-T Cell Therapy Combined With Nucleos(t)Ide Analogues in Chronic Hepatitis B Patients
This is a open-label study to evaluate the safety and efficacy of autologous T-cells transfected with messenger ribonucleic acid (mRNA) encoding Hepatitis-B virus (HBV) antigen specific T cell receptor (TCR) in combination with…
- Trial name
- NCT06885710
- Testing
- LioCyx-M
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Changhai Hospital
Nephrolithiasis
RIRS With Flex Suction Sheath vs. PCNL for 2-3 cm Renal Stones
This is a multicenter, randomized controlled trial comparing retrograde intrarenal surgery (RIRS) using a tip-flexible suction access sheath with standard percutaneous nephrolithotomy (PCNL) for the treatment of 2-3 cm unilateral…
- Trial name
- NCT07058402
- Testing
- Retrograde Intrarenal Surgery (RIRS) with Tip-Flexible Suction Access Sheath, Standard Percutaneous Nephrolithotomy (PCNL)
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Changhai Hospital
Colitis, IBD (Inflammatory Bowel Disease)
Evaluate the Efficacy and Safety of Probiotic 6600 as an Adjuvant Therapy for Colitis
This study was conducted in two phases. In Phase I, 40 UC participants, 40 CD participants, and 40 colitis participants were randomly assigned in a 1:1 ratio to the experimental group and the control group, respectively.
- Conditions
- Colitis, IBD (Inflammatory Bowel Disease), Probiotic Intervention
- Trial name
- NCT07047339
- Testing
- Probiotics 6600
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Pancreatic Diseases
The 22G Trident Needle Combined With Different Aspiration Techniques for Endoscopic Ultrasound-guided Fine-needle Biopsy
The goal of this clinical study is to compare the tissue adequacy, cellularity, blood contamination, accuracy, sensitivity, specificity of the 22G Trident needle combined with three different aspiration techniques (dry-suction…
- Trial name
- NCT07023562
- Testing
- ABC suction sequence, ACB suction sequence, BAC suction sequence
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Changhai Hospital
Pancreatic Diseases
The 22G Franseen Needle Combined With Different Aspiration Techniques for Endoscopic Ultrasound-guided Fine-needle Biopsy
The goal of this clinical study is to compare the tissue adequacy, cellularity, blood contamination, accuracy, sensitivity, specificity of the 22G Franseen needle combined with three different suction techniques (dry-suction…
- Trial name
- NCT07023549
- Testing
- ABC, ACB, BAC
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Changhai Hospital
Advanced Gastric Cancer
Fecal Microbiota Transplantation (FMT) in Patients With Advanced Gastric Cancer
This study is a randomized, double-blind and placebo-controlled study. The purpose of this study is to evaluate the efficacy and safety of FMT capsules combined with chemotherapy and anti-PD1/PDL1 therapy in the advanced gastric…
- Trial name
- NCT06346093
- Testing
- Fecal Microbiota Transplantation Capsules
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Changhai Hospital
Pancreatic Diseases
Fine-needle Biopsy Combined With Macroscopic On-site Evaluation for Diagnosis of Solid Pancreatic Lesions
The goal of this clinical trial is to compare the diagnostic efficacy, core tissue acquisition ability, number of punctures and puncture time of macroscopic on-site evaluation (MOSE) and two punctures alone in Endoscopic…
- Trial name
- NCT06994611
- Testing
- MOSE application, Conventional processing
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
CAR-NK Cells (CL-NK-001) in Pancreatic Cancer
This is a single-center, open-label, first-in-human, dose-escalation study in patients with pancreatic cancer.
- Trial name
- NCT06816823
- Testing
- CL-NK-001
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Benign Biliary Strictures
Long-Term Outcomes of Different Stents for Benign Biliary Strictures Caused by Chronic Pancreatitis
This observational study aims to observe and compare the long-term effectiveness and safety of different types of stents for benign biliary strictures secondary to chronic pancreatitis.
- Conditions
- Chronic Pancreatitis, Benign Biliary Strictures, Stenting Treatment, ERCP
- Trial name
- SOLID (NCT06981975)
- Testing
- single plastic stent, Multiple plastic stents, Fully covered self-expanding metal stents
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Changhai Hospital
Esophageal Cancer, Squamous Cell
Diagnostic Accuracy of Endocytoscopy for Superficial Esophageal Neoplasia
In recent years, endocytoscopy (EC) has undergone rapid development as an advanced endoscopic technique. Characterized by real-time histological imaging and detection capabilities, EC enables visualization of living cells in the…
- Trial name
- NCT06984055
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Metformin in Post Chronic Pancreatitis Diabetes Mellitus
The goal of this clinical trial is to evaluate the efficacy and safety of metformin in treating patients with post chronic pancreatitis diabetes mellitus (PPDM-C).
- Trial name
- MOOD (NCT06937294)
- Testing
- Metformin
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Benign Biliary Stricture
Single Plastic Stent Vs. Fully Covered Self-Expanding Metal Stent on Benign Biliary Stricture Secondary to Chronic Pancreatitis
The goal of this clinical trial is to compare the efficacy and safety of a single plastic stent versus a fully covered self-expanded metal stent in relieving benign biliary stricture secondary to chronic pancreatitis.
- Trial name
- ESSENCE (NCT06655051)
- Testing
- endoscopic retrograde biliary drainage (single plastic stent), endoscopic retrograde biliary drainage ( fully covered self-expanding metal stent)
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Changhai Hospital
Advanced Pancreatic Cancer
Statin Addition to Chemotherapy for Advanced Pancreatic Cancer
The results of previous studies conducted by our team have revealed that the use of statins can more effectively hinder the growth of drug-resistant pancreatic cancer cells.
- Trial name
- NCT06241352
- Testing
- statin addition to chemotherapy
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Changhai Hospital