Clinical trials: sponsored by Chinese PLA General Hospital
Unresectable Pancreatic Cancer
Nimotuzumab Plus S1 Versus Placebo Plus S1 as Maintenance Treatment in Patients With Unresectable Pancreatic Cancer
Background: Monotherapy with S-1, oral fluoropyrimidine, shows non-inferiority to gemcitabine in overall survival (OS) with good tolerability for advanced pancreatic cancer in Asian patients.
- Trial name
- NCT02945267
- Testing
- Nimotuzumab plus S1
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Contrast-induced Nephropathy
Efficacy Study of Vitamin D to Treat Contrast-induced Nephropathy
The investigators planned to research the effect of vitamin D supplementation on the incidence of contrast-induced nephropathy in patients undergoing coronary angiography.
- Trial name
- NCT02489240
- Testing
- vitamin D3 tablets
- Where
- China
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Pulmonary Disease, Chronic Obstructive
Evaluate the Efficacy of Xuebijing Injection in Acute Exacerbations of COPD
Objective: A prospective multicenter randomized controlled trial to assess the efficacy and safety of Xuebijing injection for acute exacerbation of chronic obstructive pulmonary disease(AECOPD).
- Trial name
- NCT02937974
- Testing
- Xuebijing
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Chinese PLA General Hospital
Ischemic Cardiomyopathy
Clinical Study of Liraglutide in Improving Cardiac Function for Patients With Ischemic Cardiomyopathy
It has been known that liraglutide reduces infarct size, improved left ventricular function, reduce myocardial stunning, and play a protective role in myocardial ischemia-reperfusion injury for patients with acute myocardial…
- Trial name
- NCT02930265
- Testing
- Liraglutide
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Acute Kidney Injury, Sepsis
Value of Urine sTREM-1 on Early Predicting AKI in Sepsis
The purpose of this study is to determine the value of urine sTREM-1 on early predicting secondary acute kidney injury in sepsis
- Trial name
- NCT02920736
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Recurrent Adult Acute Myeloid Leukemia
Decitabine Followed by Donor Lymphocyte Infusion for Patients With Relapsed Acute Myeloblastic Leukemia(AML) After Allogeneic Stem Cell Transplantation
Decitabine can up-regulate a series of immune associated proteins, including cancer testis antigens (CTA), major histocompatibility complex (MHC), co-stimulatory molecules and adhesion molecules, which suggests a potential…
- Trial name
- NCT01758367
- Testing
- Deciatbine(DAC)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
To investigate multimodel MRI exploring the pathophysiology of multiple sclerosis and neuromyelitis optica spectrum disorders. The investigators use multimodel MRI to evaluate the extent of blood-brain barrier and white matter…
- Trial name
- NCT02836327
- Testing
- Magnetic Resonance Imaging
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Dipeptidyl-peptidase-4, STEMI
Plasma Dipeptidyl-peptidase-4 Activities With No-reflow and Bleeding
Dipeptidyl-peptidase-4 (DPP4) is an important regulator of incretins and inflammation, and participates in the pathophysiological process of acute myocardial infarction (AMI).
- Conditions
- Dipeptidyl-peptidase-4, STEMI, PCI, No-reflow
- Trial name
- NCT02849691
- Volunteers
- 747 people
- Sponsor
- Chinese PLA General Hospital
Coronary Angiography, Glucagon-Like Peptide 1
Plasma GLP1 and Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention
The purpose of this study is to evaluate the predicting role of plasma GLP1 level on major adverse cardiovascular events (MACE) in patients with acute myocardial infarction who undergo percutaneous coronary intervention.
- Trial name
- NCT02846168
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Cardiovascular Diseases
Effect of Trimetazidine During the Primary PCI on Cardiac Function in Patients With ST-elevation Myocardial Infarction
Giving preoperative loading dose of 60mg of trimetazidine can safely and effectively reduce the PCI-related myocardial damage for the patients undergoing selective PCI.
- Trial name
- NCT02826616
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Chronic Obstructive Pulmonary Disease, Emphysema
Endobronchial Valve in Patients With Heterogeneous Emphysema
To compare the clinical outcomes of Endoscopic Lung Volume Reduction using Pulmonx Zephyr Endobronchial Valve (EBV) vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema patients in a controlled trial design…
- Trial name
- NCT02823223
- Testing
- Zephyr endobronchial valve placement
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Chinese PLA General Hospital
Cardiovascular Diseases
Effects of Ticagrelor on No-reflow in Patients With Acute ST-segment Elevation Myocardial Infarction
The 'no-reflow' phenomenon after a percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) is a strong predictor of both short- and long-term mortality.
- Trial name
- NCT02798874
- Testing
- Ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Systemic Inflammatory Response Syndrome, Sepsis
Vitamin D and Critically Ill Patients
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and…
- Trial name
- NCT01636232
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Gastric Carcinoma
Immunotherapy of Gastric Cancer With Autologous Tumor Derived Heat Shock Protein gp96
The purpose of this study is to evaluate the safety and effectiveness of autologous gp96 treatment of gastric cancer.
- Trial name
- NCT02317471
- Testing
- autologous gp96 vaccination, Oxaliplatin+S-1
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Chinese PLA General Hospital
Chronic Kidney Disease
Efficacy and Safety of Abelmoschus Manihot for Chronic Kidney Disease
Huangkui Capsule is a single medicament of traditional Chinese medicine consists of Abelmoschus manihot and has been widely used to treat kidney disease.
- Trial name
- NCT02231138
- Testing
- Abelmoschus manihot (AM)
- Where
- 78 sites in China
- Volunteers
- 1,600 people
- Sponsor
- Chinese PLA General Hospital
Coronary Disease
Bivalirudin in Stable Ischemic Heart Disease Patients Undergoing PCI
Prolonging infusions may decrease myocardial damage associated with bivalirudin use during primary PCI. The investigators hypothesized that continuing the bivalirudin infusion commenced during the procedure at the PCI recommended…
- Trial name
- NCT02787317
- Testing
- bivalirudin, Heparin
- Where
- 2 sites in China
- Volunteers
- 1,770 people
- Sponsor
- Chinese PLA General Hospital
Leukemia
Study of Busulfan and FLAG Conditioning Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation
The purpose of this study is to determine the safety and efficacy of Busulfan/FLAG (fludarabine, cytarabine and granulocyte colony-stimulating factor) Conditioning Regimen in Patients with Relapsed/refractory Acute Leukemia…
- Trial name
- NCT02784561
- Testing
- Busulfan (Zhejiang Otsuka Pharmaceutical Co. Ltd), Cytarabine(Actavis Italy S.p.A), Fludarabine (Bayer)
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Extensive-stage Small Cell Lung Cancer
Temozolomide as Maintenance Therapy Following Induction Chemotherapy in Extensive Stage Small Cell Lung Cancer
Temozolomide may delay progression in sequence with chemotherapy. This open-label, randomized,multicenter phase II trial was designed to evaluate the role of Temozolomide following 4 or 6 cycles of platinum-based first-line…
- Trial name
- NCT02772107
- Testing
- Temozolomide, first-line chemotherapy, Prophylactic cranial irradiation
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Chinese PLA General Hospital
Liver Cancer, Surgery
Study of Liver Resection With Versus Without Hepatic Inflow Occlusion for the HBV-related HCC
The study aims to compare the perioperative and long-term outcomes of liver resection for HBV-related HCC with versus without hepatic inflow occlusion.
- Trial name
- OHx-NOHx (NCT02563158)
- Testing
- non-occlusion technique
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Chinese PLA General Hospital
Cartilage Diseases
Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions
This study is aimed at evaluating the feasibility and effectiveness of a completely natural tissue engineered cartilage, composed of a self-made tissue engineered oriented scaffold and autologous chondrocytes, for repairing…
- Trial name
- NCT02770209
- Testing
- biomimetic cartilage matrix + autologous chondrocytes, arthroscopic debridement, microfracture surgery
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital