Clinical trials: sponsored by Chinese PLA General Hospital
Depression, Anxiety
Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery
A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery
- Conditions
- Depression, Anxiety, S-ketamine, Breast Cancer
- Trial name
- NCT07367542
- Testing
- Esketamine 0.3mg/kg, Normal Saline
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Chinese PLA General Hospital
Hypoxemia
Extubation Safety Via Microstream EtCO₂ (IPI) Monitoring
The goal of this clinical trial is to evaluate whether extubation guided by the Integrated Pulmonary Index (IPI)-a composite respiratory score derived from microstream sidestream end-tidal carbon dioxide (EtCO₂)…
- Trial name
- NCT06975553
- Testing
- endotracheal intubation-type end-tidal carbon dioxide sampling tube
- Where
- China
- Volunteers
- 632 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium, Type 2 Diabetes
Association of Preoperative Hippocampal Glucose Metabolism With Postoperative Delirium in Older Diabetic Patients
Objective: To investigate the association between preoperative hippocampal glucose metabolism levels and the risk of postoperative delirium (POD) in elderly patients with type 2 diabetes (T2DM), and to provide a prospective…
- Trial name
- NCT07369466
- Volunteers
- 154 people
- Sponsor
- Chinese PLA General Hospital
Chronic Kidney Disease, Overactive Bladder
Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly
This study focuses on Beijing community residents aged 60 and above, aiming to understand how urinary function (like bladder or kidney function) and multiple health problems (such as high blood pressure, diabetes) affect each…
- Conditions
- Chronic Kidney Disease, Overactive Bladder, Benign Prostatic Hyperplasia, Female Pelvic Floor Dysfunction
- Trial name
- UFMR-BE (NCT07357714)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Haploidentical Hematopoietic Stem Cell Transplantation
Targeted Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation
The purpose of this study is to determine the response and toxicity rate of two different dosages (Individualized dosage VS. fixed dosage) of ATG as a prophylaxis for acute GVHD in haploidentical peripheral blood stem cell…
- Trial name
- NCT05166967
- Testing
- Individual Antithymocyte globulin, Antithymocyte globulin
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Chinese PLA General Hospital
Acute Myeloid Leukemia
Venetoclax Plus CACAG Regimen for Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to compare the efficacy and safety of venetoclax combined with CACAG regimen with the traditional "3+7" regimen in the treatment of newly diagnosed acute myeloid leukemia.
- Trial name
- NCT06068621
- Testing
- Azacytidine;Cytarabine;Aclacinomycin;Chidamide;Venetoclax;Granulocyte colony-stimulating factor, "3+7"
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Pneumonia
A Randomized Controlled Trial (RCT) of Yiqi Huoxue Jiedu Formula Combined With Bacteriophages in the Treatment of Severe Pneumonia Caused by Drug-resistant Gram-negative Bacilli
Through a prospective randomized controlled trial, we systematically evaluate the effects of Yiqi Huoxue Jiedu Formula combined with bacteriophage therapy on the bacterial clearance rate, disease improvement rate and mortality…
- Trial name
- NCT07338123
- Testing
- YHDF Drug, Bacteriophage
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Frailty in Older Adults, All Cause Mortality
Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients
Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings.
- Conditions
- Frailty in Older Adults, All Cause Mortality, Trajectory
- Trial name
- NCT07322809
- Where
- China
- Volunteers
- 4,417 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium (POD), Frailty at Older Adults
Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients
Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear.
- Conditions
- Postoperative Delirium (POD), Frailty at Older Adults, Lymphocyte
- Trial name
- NCT07322744
- Where
- China
- Volunteers
- 6,475 people
- Sponsor
- Chinese PLA General Hospital
ST Elevation Myocardial Infarction (STEMI)
Effect of Long Term Trimetazidine Treatment on Final Myocardial Fibrosis for ST Eleviation Myocardial Infarction
Trimetazidine is a agent promoting glucose utilization by limiting fatty-acid oxidation.Trimetazidine could improve cardiac function in patients with ischemic heart disease.
- Trial name
- Easy (NCT07325955)
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Chinese PLA General Hospital
Ineligible Or Refused Transplant Patients With Classical Hodgkin Lymphoma
Chidamide Decitabine Plus Anti-PD-1 Antibody for Patients With R/R cHL Who Are Transplant-ineligible or Refused Transplant.
The prognosis for patients with relapsed/refractory classical Hodgkin lymphoma (cHL) who refuse or are ineligible for transplant is poor.
- Trial name
- NCT06393361
- Testing
- Chidamide; Decitabine; Anti-PD-1 Antibody, Brentuximab Vedotin, anti-PD-1 antibody.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Lymphoma
GSL Synthetase Inhibitor Eliglustat Combined With CD30 Target Immunotherapy for the Treatment of of CD30+ Lymphoma
Targeted therapy against the CD30 molecule has achieved some progress in CD30-positive Hodgkin lymphoma, but its efficacy remains unsatisfactory.
- Trial name
- NCT07138547
- Testing
- Eliglustat, CD30 target immunotherapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium (POD), Frailty at Older Adults
Associations of Postoperative Delirium With Perioperative Frailty Worsening and Their Combined Effect on 1-Year Mortality in Older Surgical Patients
Postoperative delirium (POD) is a frequent complication in older surgical patients and is associated with adverse outcomes, while frailty is also highly prevalent during the perioperative period.
- Conditions
- Postoperative Delirium (POD), Frailty at Older Adults, Mortality, Recovery of Function
- Trial name
- NCT07259850
- Where
- China
- Volunteers
- 6,196 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium (POD)
The Impact of Methylprednisolone Sodium Succinate on Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgery: A Target Trial Emulation Study
Glucocorticoids can be used to inhibit postoperative systemic inflammatory response syndrome. They may reduce the risk of major complications and mortality.
- Trial name
- NCT07271394
- Testing
- Administration of methylprednisolone sodium succinate during general anesthesia induction, No administration of methylprednisolone sodium succinate during general anesthesia induction
- Where
- China
- Volunteers
- 25,800 people
- Sponsor
- Chinese PLA General Hospital
Functional Status, Postoperative Complications
Association Between Preoperative Health and Functional Status and Postoperative Complications in Elderly Patients
Using prospectively collected clinical data from the Chinese Perioperative Database of Elderly Patients, this study retrospectively analyzed patients aged ≥65 years who underwent elective non-cardiac, non-neurosurgical procedures…
- Conditions
- Functional Status, Postoperative Complications, Older Adults (65 Years and Older)
- Trial name
- NCT07259837
- Where
- China
- Volunteers
- 8,751 people
- Sponsor
- Chinese PLA General Hospital
ST Elevation (STEMI) Myocardial Infarction
Correlation Between Triglyceride Glucose Index and Myocardial Injury Assessed by Cardiac Magnetic Resonance Imaging (CMR) in Patients With STEMI
This research aim is to investigate the correlation between triglyceride glucose index (TyG index) and myocardial infarct size, microcirculation obstruction (MVO) and intramyocardial hemorrhage (IMH) assessed by cardiac magnetic…
- Trial name
- NCT07261514
- Where
- China
- Volunteers
- 674 people
- Sponsor
- Chinese PLA General Hospital
Benign Prostate Hypertrophy(BPH)
Evaluation of the Application Effect of a Surgical Navigation System in HoLEP Surgery
3D imaging-assisted surgical navigation system was established using the following specific procedures: 1) Prostate MRI Acquisition and 3D Reconstruction: patient prostate MRI images are acquired, and professional engineers…
- Trial name
- NCT07251621
- Testing
- use the 3D imaging-assisted surgical navigation system during surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Epilepsy (Treatment Refractory)
A Study to Evaluate the Safety and Effectiveness of Magnetic Resonance-Guided Ultrasound Ablation of the Anterior Nucleus of Thalamus for the Treatment of Drug-resistant Epilepsy.
The study "Safety and Efficacy Evaluation of MR-Guided Focused Ultrasound Anterior Thalamic Nucleus Ablation for Drug-Resistant Epilepsy" from Chinese PLA General Hospital, is a single-center, prospective, single-arm study.
- Trial name
- NCT07249190
- Testing
- MR-guided Focused Ultrasound Therapy
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Depression, Anxiety, Cardiac Surgery
Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve Surgery
A multicenter, randomized controlled, blinded prospective study to investigate the effects of esketamine on perioperative anxiety and depression in patients undergoing cardiac valve surgery.
- Conditions
- Depression, Anxiety, Cardiac Surgery, S-ketamine
- Trial name
- NCT06608030
- Testing
- Esketamine, normal saline
- Where
- 2 sites in China
- Volunteers
- 142 people
- Sponsor
- Chinese PLA General Hospital
Solid Tumor, Adult, EphA2 Overexpression
CAR-DC Vaccine and ICIs in Local Advanced/Metastatic Solid Tumors
This is a pilot clinical trial for subjects with local advanced/metastatic solid tumors to determine the safety, efficacy and immune response of autologous EphA2-targeting CAR-DC vaccine loaded with KRAS mutant peptide…
- Conditions
- Solid Tumor, Adult, EphA2 Overexpression, KRAS G12V, KRAS G12C
- Trial name
- NCT05631899
- Testing
- KRAS-EphA-2-CAR-DC, Abraxane, Cyclophosphamide
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Chinese PLA General Hospital