Clinical trials: open to volunteers, sponsored by Chinese University of Hong Kong
Lung Cancer (NSCLC)
Postoperative Pulmonary Function Assessment Based on Deep Learning Study
Improvements in low-dose CT screening have led to an increase in early-stage NSCLC diagnoses, with surgical resection-usually lobectomy or segmentectomy-remaining the primary curative option.
- Trial name
- NCT07256457
- Testing
- Segmentectomy, Lobectomy, Bronchoscopic Ablation
- Where
- Hong Kong
- Volunteers
- 192 people
- Sponsor
- Chinese University of Hong Kong
Membranous Nephropathy
Correlation and Clinical Utility of Urinary Biomarker in Membranous Glomerulonephritis
To assess the correlation of these urinary biomarkers with the serum sample and evaluated the clinical utility of using urinary sample in the detection and prognostication of MGN.
- Trial name
- NCT05688865
- Testing
- urinary markers
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Post ERCP Pancreatitis
Comparative Effectiveness Between Indomethacin and Pancreatic Stenting in the Prevention of Post ERCP Pancreatitis
Post ERCP pancreatitis (PEP) occurs in 4 to 5% of patients and is associated with significant morbidities and occasional mortalities.
- Trial name
- NCT03713879
- Testing
- pancreatic stenting, Indomethacin
- Where
- 7 sites in China, Hong Kong and 1 more
- Volunteers
- 1,734 people
- Sponsor
- Chinese University of Hong Kong
COPD
A Prospective Study of Cardiovascular Risk of Patients Admitted for Acute Exacerbation of COPD
This is a prospective study to assess the burden of existing or hidden cardiovascular (CV) and renal disease in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a Hong Kong public hospital…
- Trial name
- NCT07344285
- Testing
- Intervention Group, Usual Care
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Acute Aortic Syndrome
Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome
The goal of this study is to evaluate the safety of integrating the Aortic Dissection Detection Risk Score (ADD-RS) and D-dimer testing for ruling out acute aortic syndrome (AAS) in the emergency department (ED).
- Trial name
- NCT07640334
- Testing
- D-dimer test
- Where
- 2 sites in Hong Kong
- Volunteers
- 746 people
- Sponsor
- Chinese University of Hong Kong
Thoracic Neoplasms
Post-operative Medium Chain Triglyceride Diet May Reduce Hospital Stay Following Lung Resection
Lung resection, a critical treatment for various thoracic diseases, including lung cancer, often necessitates prolonged hospitalization due to rare but severe postoperative complications such as chyle leaks, with an occurrence of…
- Trial name
- NCT07159659
- Testing
- MCT Diet
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- Chinese University of Hong Kong
Stage IA NSCLC
Study of Robotic Assisted/Image Guided Electromagnetic Navigation Bronchoscopic Therapies and Surgery in Stage IA NSCLC
This study aims to address the core deficiencies in the field by situating bronchoscopic ablation within the same evidentiary frame as segmentectomy and lobectomy.
- Trial name
- NCT07741344
- Testing
- Bronchoscopic Microwave Ablation, Surgical Resection
- Where
- Hong Kong
- Volunteers
- 292 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea (OSA)
Myofunctional Therapy for Children With OSA
Myofunctional therapy (MFT) has been proposed as an adjunctive therapy for obstructive sleep apnoea (OSA) in children. Some studies have reported improved sleep parameters and reduced oral breathing after MFT.
- Trial name
- NCT07249944
- Testing
- Myofunctional therapy
- Where
- Hong Kong
- Volunteers
- 174 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Microbiome and Metabolomics Profiling in Children With OSA
Objectives: Obstructive sleep apnoea (OSA) exhibits variable susceptibility to end-organ morbidities. Previous studies suggest that physiological sequelae in individuals with OSA promote changes in microbiome, which also interact…
- Trial name
- NCT06452992
- Where
- Hong Kong
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Lung Cancer (NSCLC)
Navigation Bronchoscopy Guided Microwave Ablation Versus SBRT in Early NSCLC
Background: Stereotactic body radiotherapy (SBRT) is a standard definitive local therapy for medically inoperable early stage non-small cell lung cancer (NSCLC).
- Trial name
- NCT07722182
- Testing
- Navigation Bronchoscopy-Guided Microwave Ablation, Stereotactic Body Radiotherapy (SBRT)
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Herb-drug Interactions
Developing a Methodological Framework and a Dissemination Plan for Herb-drug Interactions-related Clinical Practice Guidelines
The goal of this observational study is to develop a methodological framework for clinical practice guidelines (CPGs) related to herb-drug interactions (HDIs).
- Trial name
- NCT07248826
- Testing
- Delphi method survey, Semi-structured interview
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Thoracic Cancer
Thoracic Surgery by the Medtronic Hugo™ Robotic System
The introduction of robot-assisted surgery is one of the biggest breakthroughs in surgery, and represents the most significant advancement in minimally invasive surgery of recent decades.
- Trial name
- NCT06669104
- Testing
- Medtronic Hugo™ surgical robotic system
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Renal Failure Chronic Requiring Dialysis, Peritoneal Dialysis
Bisacodyl Oral for Lowering Dysfunction (of Tenckhoff Catheter)
Doctors need to insert catheter for patients who are going to have peritoneal dialysis. These peritoneal catheters can be obstructed or blocked afterward. The chance of not having smooth flow can be up to 12 and 31%.
- Trial name
- BOLD (NCT07351357)
- Testing
- Bisacodyl 5 mg
- Where
- 6 sites in Hong Kong
- Volunteers
- 398 people
- Sponsor
- Chinese University of Hong Kong
Influenza
Intravenous N-acetylcysteine and Oseltamivir Versus Oseltamivir in Adults Hospitalized With Influenza and Pneumonia
Seasonal influenza epidemics are important causes of morbidity and mortality. Cytokine dysregulation, with high levels of pro-inflammatory cytokines, occurs in patients with severe influenza.
- Trial name
- NCT03900988
- Testing
- N-acetyl cysteine, 5% Dextrose
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
HCC - Hepatocellular Carcinoma, Cirrhosis
Non-invasive Assessment for Outcome Prediction in Patients With Hepatocellular Carcinoma
This is a single-centre, prospective cohort study. Consecutive patients with compensated liver disease and hepatocellular carcinoma (HCC) for curative-intent treatment will be invited to this study.
- Trial name
- NCT07036874
- Testing
- transient elastography and oesophagogastroduodenoscopy
- Where
- Hong Kong
- Volunteers
- 159 people
- Sponsor
- Chinese University of Hong Kong
Cirrhosis, Advanced Chronic Liver Disease
Natural History of Advanced Chronic Liver Diseases
This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years.
- Trial name
- NCT07042308
- Testing
- Transient elastography
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer
Personalized Antiemetic Regimen According to Patients' Pharmacogenetic Profile
The objectives of this study are to determine if pharmacogenetic (PG) analysis of an individual enable optimal selection of antiemetic regimen for patients undergoing the first cycle of AC (Adriamycin + Cyclophosphamide) or FEC…
- Trial name
- NCT07455955
- Testing
- Standard antiemetic regimen or Olanzapine antiemetic regimen
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Catheter-Associated Urinary Tract Infections (CAUTIs)
Evaluate of the Use of Uromune as a Potential Non-antibiotic Prophylactic Strategy for Catheter-associated Urinary Tract Infection in Patients With Long-term Catheterization.
A self-controlled pilot study to evaluate the use of oral bacterial immunotherapy for prevention of catheter-associated urinary tract infection.
- Trial name
- NCT07869992
- Testing
- Uromune
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Infertility Assisted Reproductive Technology
Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical…
- Trial name
- NCT07858227
- Testing
- data collection
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Kidney Diseases, Metabolic Syndrome
HAPA-based Intervention in Adults With Metabolic Syndrome and Chronic Kidney Disease
This study will adopt a 2-arm, pretest-posttest, and assessor-blind RCT design to examine the effectiveness of a theory-based health behaviour change intervention on WC (primary outcome), kidney function (eGFR, primary outcome)…
- Trial name
- NCT06715735
- Testing
- HAPA-based intervention
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong