Clinical trials: completed, sponsored by Duke University
Hypertension
Food as Medicine Project
Causes' Fresh Produce Program (FPP) in Durham County has addressed barriers to food security related to transportation with an innovative delivery model, but lacks evidence regarding the impact of food supplementation on chronic…
- Trial name
- NCT05926193
- Testing
- Tailor Food Bags
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Duke University
Chemotherapeutic Toxicity
Machine Learning to Predict Acute Care During Cancer Therapy
The objective of this study is to apply a validated machine-learning based model (SHIELD-RT, NCT04277650) to a cohort of patients undergoing systemic therapy as outpatient cancer treatment to generate an automatic system for the…
- Trial name
- Chemo-SHIELD (NCT05122247)
- Testing
- Machine learning algorithm
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Duke University
Systemic Lupus Erythematosus
Utilizing Qualitative and Quantitative Methods to Understand a New Model of Type 1 and 2 Systemic Lupus Erythematosus (SLE)
The purpose of this study is to pilot test SLE@Duke, a set of tools to implement the Type 1 \& 2 SLE Model in a clinical setting, as well as to gain an in-depth understanding of providers experiences using the intervention during…
- Trial name
- NCT05426902
- Testing
- SLE@Duke
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Pre Diabetes, Obesity
Balanced (Egg) Protein During Obesity Reduction: Differential Responses of Insulin Resistance by Race
The purpose of the trial is to assess the effects of combining regular, generous intakes of high quality protein (with substantial amounts provided from whole eggs and egg whites) with calorie restriction on insulin resistance…
- Trial name
- EGGSPDITe (NCT03771261)
- Testing
- Weight Loss, Egg Protein
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
Breast Neoplasms, Early Detection of Cancer
Promoting Breast Cancer Screening in Women Who Survived Childhood Cancer
The primary purpose of this study is to determine the impact of maximizing patient and primary care provider (PCP) activation on breast cancer surveillance rates among women previously treated with chest radiotherapy (RT) for a…
- Trial name
- NCT03435380
- Testing
- Patient activation, Primary care physician activation, Control
- Where
- 5 sites in United States
- Volunteers
- 314 people
- Sponsor
- Duke University
Atrial Fibrillation
Understanding and Improving Anticoagulation Dosing for Patients With Atrial Fibrillation
This study will survey atrial fibrillation patients to better understand patient perspective of DOAC treatment, and providers to assess knowledge, practice patterns, and beliefs surrounding anticoagulation for AF.
- Trial name
- ARISTA (NCT03719144)
- Where
- United States
- Volunteers
- 581 people
- Sponsor
- Duke University
Health Care Worker (HCW), COVID-19
Healthcare Worker Exposure Response and Outcomes (HERO) Registry Study, COVID-19
The HERO Registry provides a resource for collecting information on Healthcare Workers (HCWs) currently working in the United States, and their families and communities.
- Trial name
- NCT04342806
- Where
- United States
- Volunteers
- 51,466 people
- Sponsor
- Duke University
Rectum Cancer
Patient-Derived Organoids for Rectal Cancer
The purpose of this study is to determine the feasibility of establishing patient-derived organoids from pre-treatment rectal adenocarcinoma biopsies.
- Trial name
- NCT04371198
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Misophonia, Emotion Dysregulation
Identifying the Optimal Neural Target for Misophonia Interventions
Misophonia, the inability to tolerate certain repetitive aversive sounds that are common, is gaining recognition as a debilitating condition. It is not a well-understood condition and there are no known treatments.
- Trial name
- NCT04348591
- Testing
- Cognitive Restructuring, neurostimulation
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Duke University
Advanced Cancer
Caregiver-Guided Pain Management Training in Palliative Care
The purpose of this study is to develop more effective ways to help patients and their caregivers cope with cancer pain. The investigators are looking at the usefulness of a Caregiver-Guided Pain Management Training Intervention…
- Trial name
- NCT02430467
- Testing
- Caregiver-guided pain management training (CG-PMT), Enhanced treatment-as-usual (TAU)
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Duke University
ADHD
Ventral Tegmental Area (VTA) Self-Activation in Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this study is to see if a non-medication intervention can increase motivation in individuals with ADHD by observing brain activity using magnetic resonance imaging (MRI).
- Trial name
- NCT02723708
- Testing
- Real-Time functional Magnetic Resonance Imaging Feedback (RTFF)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Syncope, Vasovagal
Presyncope (Syncope) Prevention Study
This study was a prospective, randomized clinical trial that was conducted in adolescents (10 through 14 years of age) receiving at least one recommended intramuscularly administered vaccine to evaluate the efficacy and…
- Trial name
- PS^2 (NCT04772755)
- Testing
- Buzzy® and Electronic Game
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Duke University
Male Stress Urinary Incontinence
Study of Urethral Mobility in Male Stress Urinary Incontinence Pre- and Post- Placement of Transobturator Sling
The hypothesis is men with stress urinary incontinence, including those following radical retropubic prostatectomy and other prostate surgery, have preoperative urethral mobility as measured by magnetic resonance imaging (MRI)…
- Trial name
- NCT01779323
- Testing
- Pre and Post Sling Pelvic MRI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
Optical Spectroscopy During Breast Cancer Surgery and Core Needle Biopsy
The objective of the proposed research is to develop new diagnostic modalities based on optical spectroscopy (auto fluorescence, absorption, and scattering) for the diagnosis of breast cancer and test its performance as an…
- Trial name
- NCT00734838
- Testing
- High Resolution Microendoscope
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Duke University
PCST-Full (Pain Coping Skills Training), PCST-Brief
Optimizing Delivery of a Behavioral Cancer Pain Intervention Using a SMART
This trial is a sequential multiple assignment randomized trial (SMART), that will examine response to differing doses of a behavioral cancer pain intervention (Pain Coping Skills Training [PCST]) and subsequent response-based…
- Trial name
- SMART (NCT02791646)
- Testing
- Pain Coping Skills Training Full, Pain Coping Skills Brief
- Where
- United States
- Volunteers
- 327 people
- Sponsor
- Duke University
Mobile Pain Coping Skills Training, In Person Pain Coping Skills Training
Mobile Pain Coping Skills Training for Cancer Pain
Pain in cancer patients is estimated to be as high as 90% and results in physical and psychological disability. Behavioral interventions that increase patients' confidence in their ability to manage their pain have been shown to…
- Trial name
- NCT02266017
- Testing
- Pain Coping Skills Training
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Duke University
Diabetes Type II
Novel Biomarker for Development of T2D
The investigators wants to determine if 11β-HSD1 activity will be positively associated, and 5α-reductase activity negatively associated, with (a) degree of insulin resistance defined by the homeostatic model assessment of…
- Trial name
- NCT02326129
- Where
- 3 sites in United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes, Heart Disease
Family Health History in Diverse Care Settings (FHH)
The outcome of this research will be a demonstration that family health history (FHH) risk data can be used efficiently to deliver more effective healthcare in geographically and ethnically diverse clinical care environments.
- Conditions
- Diabetes, Heart Disease, Cancer
- Trial name
- FHH (NCT01956773)
- Testing
- MeTree
- Where
- 5 sites in United States
- Volunteers
- 2,620 people, healthy volunteers welcome
- Sponsor
- Duke University
Osteoarthritis, Knee, Osteoarthritis, Hip
Engaging African American Older Adults With Arthritis in a Physical Activity Intervention
Physical activity like walking is one important way to reduce pain and improve wellbeing for older adults with knee and hip arthritis, but most older adults and particularly those who identify as African American struggle to walk…
- Trial name
- NCT05652413
- Testing
- Adapted-Engage-PA
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Chronic Pain, Traumatic Brain Injury
Neuromodulatory Treatments for Pain Management in TBI
Traumatic brain injury (TBI) and chronic pain are common and serious health problems for military veterans and often co-occur, leading to poor post-deployment adjustment.
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder
- Trial name
- NCT03418129
- Testing
- Mindfulness, Neurofeedback, Relaxation
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Duke University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.