Clinical trials: completed, sponsored by Duke University
Knee Osteoarthritis, Primary Total Knee Arthroplasty
Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
The purpose of this study is to learn if using an Interspace between the Popliteal Artery and Capsule of the Knee (iPACK) injection technique (also called a "nerve block") that numbs the nerves going to the back part of the knee…
- Conditions
- Knee Osteoarthritis, Primary Total Knee Arthroplasty, Physical Therapy, Pain
- Trial name
- NCT03353233
- Testing
- Ropivacaine, Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Medication Adherence, Asthma
AdheRence to Inhaled Corticosteroids in Asthma
It is widely recognized that asthma in adult African American patients is a significant health problem, which is partly affected by relatively low inhaled corticosteroid (ICS) adherence rates.
- Trial name
- ARICA (NCT03769519)
- Testing
- ARICA
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Duke University
Alzheimer's Disease
Trial of Rifaximin in Probable Alzheimer's Disease
This study aims to improve cognition and function in patients with Alzheimer's Disease (AD) by administering the oral antibiotic, Rifaximin.
- Trial name
- NCT03856359
- Testing
- Rifaximin 550 milligrams (MG)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Decompression Sickness, Acute Mountain Sickness
Decompression Tables for Diving at Altitude
The aims of this proposal are to test current USN procedures for adjusting decompression procedures during air diving at 8,000 and 10,000 ft altitude and to provide a decompression algorithm for no-stop dives to 100 feet of sea…
- Trial name
- NCT03390335
- Testing
- Pressure, Breathing Gas
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Duke University
CNS Oxygen Toxicity, Ketogenic Diet
Ketogenic Diet for Reduction of CNS Oxygen Toxicity in Working Divers
The purpose of this research study is to understand the effect of nutritional ketosis on CNS oxygen toxicity in undersea divers.
- Trial name
- NCT03433261
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Failure
EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study)
The primary objective of the study is to determine whether, in patients with symptomatic, advanced heart failure due to left ventricular systolic dysfunction, treatment with LCZ696 for 24 weeks will improve Pro-B-type Natriuretic…
- Trial name
- HFN-LIFE (NCT02816736)
- Testing
- LCZ696, valsartan
- Where
- 38 sites in United States
- Volunteers
- 365 people
- Sponsor
- Duke University
Parents During COVID-19
Expressive Writing for COVID-19 Resilience for Parents
The purpose of this study is to determine the impact of a 4-week, virtually-delivered expressive writing intervention on resilience in a cohort of parents and caregivers currently navigating the COVID-19 pandemic during spring \&…
- Trial name
- NCT04589117
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Duke University
Neovascular Age-related Macular Degeneration, Macular Degeneration
Photodynamic Therapy for PDA in NV AMD
The purpose of this prospective observational study is to assess the potential clinical effects of adjunctive verteporfin photodynamic therapy (PDT) for persistent disease activity among patients with neovascular age-related…
- Trial name
- NCT02452840
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Hearing Loss, Geriatric Disorder
Addressing Barriers to Adult Hearing Healthcare
The aim of this project is to develop evidence that can inform hearing health care best practices for adults between the ages of 65-75, and determine what level of involvement by the primary care practitioner (PCP) is required to…
- Trial name
- NCT02928107
- Testing
- Tele-HS, PCP encouragement
- Where
- 6 sites in United States
- Volunteers
- 1,146 people, healthy volunteers welcome
- Sponsor
- Duke University
Venous Thromboembolism
VTE Prophylaxis Guidelines in Hospitalized Elders
Guideline directed use of pharmacologic Venous thromboembolism (VTE) prophylaxis emphasizes mobility evaluation. Mobility is a key component of risk stratification.
- Trial name
- NCT03025100
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Duke University
Delirium, Hospital Acquired Condition
Earplugs and Eye Masks for Reducing Delirium
There has been some recent evidence to support the use of earplugs and eye masks to prevent delirium, but the existing studies have been small, have not been thoroughly replicated, and have only been conducted with intensive care…
- Trial name
- NCT03471520
- Testing
- Earplugs and eye masks
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Duke University
Childhood Obesity, Pediatric Obesity
A Trial of an Integrated Clinic-community Intervention in Children and Adolescents With Obesity (Hearts and Parks)
The investigators propose a randomized controlled effectiveness trial to evaluate the integrated clinic-community model of child obesity treatment as compared with routine primary care.
- Conditions
- Childhood Obesity, Pediatric Obesity, Quality of Life, Cardiovascular Risk Factor
- Trial name
- NCT03339440
- Testing
- Hearts & Parks
- Where
- 3 sites in United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Duke University
Total Knee Replacement
Virtual vs. Traditional Physical Therapy Following Total Knee Replacement
The goals of this research study are the following: 1. To compare the effects of tele-rehabilitation-supported physical therapy versus traditional home and/or clinic-based physical therapy for total knee replacement (TKR) on…
- Trial name
- NCT02914210
- Testing
- Virtual physical therapy rehabilitation program, No intervention
- Where
- 4 sites in United States
- Volunteers
- 306 people
- Sponsor
- Duke University
Pompe Disease, Glycogen Storage Disease II
Pompe Telemedicine Developmental Study
The primary purpose of this study is to: Document the developmental outcomes of individuals with Pompe disease treated with long-term enzyme-replacement therapy (ERT) through school-age (ages 6-18) using measures of cognitive…
- Trial name
- NCT02950298
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Pain
Opioid Sparing Potential of Light-Induced Analgesia
This is a pilot trial testing the potential opioid-sparing analgesic effect of a novel non-pharmacological treatment using visualized light spectrums. Preclinical findings have shown such treatments to alter pain perception.
- Trial name
- NCT03890419
- Testing
- Green light, Clear light, Blue Light
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Cerclage, Cervical
ED90 of 3% Chloroprocaine for Cervical Cerclage
The aim of this study is to identify the dose of intrathecal (IT) chloroprocaine that provides effective anesthesia in 90% of patients undergoing elective cerclage placement (intraoperative analgesic supplementation not required).
- Trial name
- NCT03805438
- Testing
- Chloroprocaine Hcl 3% Inj
- Where
- 2 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Duke University
Provider Burnout, Communication
Provider-Patient Communication Coaching
To examine the effect of a coaching intervention on provider burnout and communication
- Trial name
- NCT02783742
- Testing
- Communication coaching
- Where
- United States
- Volunteers
- 859 people
- Sponsor
- Duke University
COVID-19, SARS-CoV-2
COVID-19 Pandemic Response Network
Coronavirus Disease 19 (COVID-19) represents an unprecedented challenge to the operations and population health management efforts of health care systems around the world.
- Conditions
- COVID-19, SARS-CoV-2, Coronavirus, Influenza -Like Illness
- Trial name
- NCT04320862
- Where
- United States
- Volunteers
- 9,207 people, healthy volunteers welcome
- Sponsor
- Duke University
Ovarian Cancer, Epithelial, Peritoneal Cancer
Prospective Randomized Trial of Streamlined Genetic Education and Testing for Ovarian Cancer Patients
Current guidelines recommend universal genetic testing for all patients with ovarian, fallopian and peritoneal cancer. The purpose of this trial is to investigate the non-inferiority of streamlined genetics education and testing…
- Conditions
- Ovarian Cancer, Epithelial, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT04537702
- Testing
- Streamlined Education, Traditional Education
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Duke University
Burnout, Professional, Stress, Psychological
Targeting the Health Care Provider (HCP) Burnout Crisis During the COVID-19 Pandemic
This single blind, randomized, controlled trial (RCT) evaluates, a nonpharmacological intervention, TM (Transcendental Meditation) for improving burnout (, as measured by self-reporting (survey), physiologic, and neuro-functional…
- Trial name
- NCT04632368
- Testing
- Transcendental Meditation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University