Clinical trials: sponsored by Duke University
Cervicogenic Upper Extremity Radiculopathy
Transforaminal Versus Lateralized Interlaminar Cervical Epidurals
The purpose of this study is to compare two methods of giving epidural steroid injections for nerve pain in the arm that comes from the neck.
- Trial name
- NCT03389620
- Testing
- dexamethasone
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Duke University
Reactions to Warnings, Hookah Smoking
Reactions to Warnings on Hookah Ads
The purpose of this study is to help us better understand what kinds of waterpipe tobacco advertisements appeal to young adults as well as to help evaluate and create health warnings that can be placed on waterpipe tobacco…
- Trial name
- NCT03723616
- Testing
- Ads Only, Ads with text-only health warning labels (HWLs), Ads with text + graphic health warning labels (HWLs)
- Where
- United States
- Volunteers
- 2,588 people, healthy volunteers welcome
- Sponsor
- Duke University
Vaccine Hesitancy
Increasing Vaccine Uptake Among Adolescents in the Rural South
The benefits of adolescent vaccines are well known for preventing meningococcal infection and human papillomavirus (HPV)-related pre-cancerous lesions.
- Trial name
- INVEST (NCT04999267)
- Testing
- INVEST
- Where
- 2 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
mHealth Behavioral Cancer Pain Intervention for Medically Underserved Patients
The efficacy of a mobile health (mHealth) behavioral cancer pain intervention designed to decrease pain and disability for breast cancer patients in medically underserved areas has not been investigated.
- Trial name
- ICAN-NC (NCT04175639)
- Testing
- Mobile Health Pain Coping Skills Training (mPCST)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Hematopoietic Steam Cell Transplantation (HCT)
ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant (HCT) Patients
This is a research study to develop and test a novel protocol to reduce physical and psychological vulnerabilities that contribute to treatment intolerance and treatment-related morbidity and mortality among hematopoietic stem…
- Trial name
- NCT04423939
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid Use, Pain, Postoperative
Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
The overall goal of this research is to improve perioperative pain treatment, decrease post-operative opioid consumption, diminish opioid related side effects, and reduce postop opioid prescribing (and hence opportunity for…
- Trial name
- OSPREy (NCT03726268)
- Testing
- Methadone, Fentanyl, Hydromorphone
- Where
- United States
- Volunteers
- 907 people
- Sponsor
- Duke University
Caregivers, Technology
CLARE Mobile App for Caregiver Training and Support
This pilot study will investigate the feasibility of using a digital health application, Communication, Learning, Advocacy, Resources and Expertise (CLARE), in training and support of family and friends (i.e., caregivers) of…
- Trial name
- NCT05877586
- Testing
- CLARE app
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Adolescent and Young Adult Cancer Patient
Adolescents and Young Adults (AYAs) With Advanced Cancer
This study aims to develop and test the feasibility and acceptability of a psychosocial symptom management intervention designed to meet the unique needs of Adolescents and Young Adults (AYAs) with advanced cancer.
- Trial name
- NCT05593016
- Testing
- Symptom Management for Improved Physical and Emotional Wellbeing (SMILE), Education Control Arm
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Stem Cell Transplant
mPCST for BMT Patients
We used a small randomized controlled trial (n=36) to compare a Mobile Health Pain Coping Skills (mPCST) to Usual Treatment for patients having received hematopoietic stem cell transplant.
- Trial name
- NCT01984671
- Testing
- Mobile Pain Coping Skills Training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Duke University
Heart Failure
TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure
TRANSFORM-HF is a large-scale, pragmatic, randomized, unblinded clinical effectiveness study comparing torsemide versus furosemide as treatment for heart failure. Approximately 6,000 patients with heart failure will be enrolled.
- Trial name
- TRANSFORM-HF (NCT03296813)
- Testing
- Torsemide, Furosemide
- Where
- 60 sites in United States
- Volunteers
- 2,973 people
- Sponsor
- Duke University
Laparotomy, Colectomy
QL Block With Exparel in Colectomy
The purpose of this study is to determine if using a different type of injection of local anesthestic (pain medicine) in between the muscle layers of the abdominal wall (called a quadratus lumborum block) will improve pain…
- Trial name
- NCT03827291
- Testing
- Exparel, Thoracic epidural analgesia
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Acute Respiratory Failure, Mechanical Ventilation Complication
Assessing Ventilator Safety in Patients on Pressure-Support Ventilation
ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation.
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- ASOP (NCT05125952)
- Testing
- Viasys Avea Ventilator, Philips Respironics NM3 device, Servo U ventilator
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Colorectal Cancer
Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings (PainPac)
PainPac is innovative in its potential to integrate with healthcare systems through electronic medical records (EMRs). PainPac leverages technology to increase patient access to interventions and uses real-time assessment to…
- Trial name
- NCT05686122
- Testing
- PainPac
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Duke University
Chronic Pain, Smoking, Cigarette
Low Nicotine Cigarettes, Smoking, and Chronic Pain
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on experiences with craving, withdrawal, and pain among individuals…
- Trial name
- VLNCPain (NCT05032755)
- Testing
- SPECTRUM NRC 102/103 investigational cigarettes, SPECTRUM NRC 600/601 investigational cigarettes
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Atrial Septal Defect, Ventricular Septal Defect
Regional Anesthesia Following Pediatric Cardiac Surgery
The purpose of this study is to evaluate pain control following pediatric cardiac surgery with the use of local anesthesia via an ultrasound guided regional anesthetic technique compared with surgeon delivered wound infiltration.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Pain, Procedural
- Trial name
- NCT05688670
- Testing
- Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Duke University
Endometrial Diseases, Pain, Postoperative
Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy
The purpose of this study is to see whether transcutaneous electrical nerve stimulation (or TENS) reduces pain during an endometrial biopsy.
- Trial name
- NCT05472740
- Testing
- TENS 7000
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duke University
Hearing Loss
Safety and Feasibility of tDCS to Enhance Auditory Rehabilitation in Cochlear Implant Recipients
This study aims to evaluate the safety and feasibility of transcranial direct current stimulation (tDCS) in combination with home-based auditory training therapy in cochlear implant (CI) patients.
- Trial name
- NCT04908631
- Testing
- Transcranial Direct Stimulation, Auditory Training Program
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Stroke, Ischemic, Motor Activity
Transcranial Direct Current Stimulation for Post-stroke Motor Recovery
This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function.
- Conditions
- Stroke, Ischemic, Motor Activity, Upper Extremity Paralysis
- Trial name
- TRANSPORT 2 (NCT03826030)
- Testing
- Low dose tDCS, High dose tDCS, mCIMT
- Where
- 14 sites in United States
- Volunteers
- 129 people
- Sponsor
- Duke University
Suicide Prevention
Brief Suicide Intervention for Youth in Juvenile Detention Settings
This is an intervention development study and therefore is not designed or powered to test hypotheses. Following initial development and refinement of intervention and protocol, an open trial will be conducted at one juvenile…
- Trial name
- NCT05225103
- Testing
- SAFETY-Acute intervention
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Duke University
Amputation; Postoperative, Sequelae
Hyperbaric Oxygen and Outcome After Below Knee Amputations
This study is being conducted to assess the utility of hyperbaric oxygen as an adjunctive treatment to reduce postoperative complications.
- Trial name
- NCT04717557
- Testing
- Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University