Clinical trials: sponsored by Erasmus Medical Center
Renal Insufficiency, Chronic, Potassium Depletion
Potassium Supplementation in CKD
The current high-sodium, low-potassium diet contributes to the high prevalence of high blood pressure (hypertension). Indeed, the anti-hypertensive effects of potassium supplementation are well-established.
- Conditions
- Renal Insufficiency, Chronic, Potassium Depletion, Hypertension, Hyperkalemia
- Trial name
- K+ in CKD (NCT03253172)
- Testing
- Potassium Chloride, Potassium Citrate
- Where
- 4 sites in Netherlands
- Volunteers
- 532 people
- Sponsor
- Erasmus Medical Center
AI Governance, AI Maturity
Global AI Governance: Maturity and Implementation in Leading Hospitals for Responsible AI in Healthcare
Despite growing interest in artificial intelligence (AI) for Healthcare, successful implementation practices are still limited due to the complexity of developing and deploying AI systems.
- Conditions
- AI Governance, AI Maturity, AI
- Trial name
- NCT07727603
- Testing
- Survey and Interview
- Where
- Netherlands
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
HIV
Biomarkers for Post-treatment Control in HIV: International Study of the EU2Cure Research Consortium (Phase I)
Antiretroviral therapy (ART) has transformed HIV from a deadly disease into a lifelong infection that can be controlled. Nevertheless, in the majority of people living with HIV (PWH), discontinuation of ART results in viral…
- Trial name
- EU2Control (NCT07692295)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Acute Respiratory Distress Syndrome, Ventilator Lung
FCV vs PCV in Moderate to Severe ARDS
The goal of this clinical trial is to compare flow-controlled ventilation (FCV) and pressure-controlled ventilation (PCV) in patients with moderate to severe acute respiratory distress syndrome on the intensive care unit.
- Trial name
- NCT06051188
- Testing
- Flow-controlled ventilation
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Erasmus Medical Center
Achilles Tendinopathy (AT)
The ASPIRE Trial: AchilleS tendinoPathy Treated With cortIcosteRoid injEctions
Achilles tendinopathy is a common and often persistent tendon disorder associated with pain, impaired function, and reduced participation in physical activities.
- Trial name
- ASPIRE (NCT07650396)
- Testing
- Standard care, Depo-Medrol (methylprednisolone acetate 40 mg) combined with lidocaine
- Where
- Netherlands
- Volunteers
- 276 people
- Sponsor
- Erasmus Medical Center
Liver Transplantation
Secretin in Ex-situ Liver Perfusion
The main objective is to assess whether the use of human synthetic secretin in a clinical (COR-)NMP procedure can restore physiological HCO3- content of the bile during ex-situ NMP.
- Trial name
- NCT07651748
- Testing
- Secretin administration during ex-situ liver machine perfusion
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Pain Management, Pain Assessment
Effectiveness and Implementation of a Clinical Pain Management Dashboard for the NICU
This study protocol describes a type 1 hybrid effectiveness-implementation study evaluating a clinical decision support dashboard for neonatal pain management in a tertiary NICU.
- Conditions
- Pain Management, Pain Assessment, Neonatal Intensive Care, Implementation Research
- Trial name
- NCT07629661
- Testing
- Implementation of clinical pain management dashboard
- Where
- Netherlands
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Pulmonary Fibrosis, Interstitial Lung Disease (ILD)
Implementation of Home Monitoring in Patients With Pulmonary Fibrosis
The objective of this study is to evaluate the impact of structurally replacing half of the outpatient clinic visits for patients with pulmonary fibrosis by home monitoring and video consultations on patient self-management and…
- Trial name
- SUITS (NCT06883448)
- Testing
- Home monitoring care
- Where
- 11 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Erasmus Medical Center
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
Perioperative or Adjuvant mFOLFIRINOX for Resectable Pancreatic Cancer
The PREOPANC-3 study is a randomized, multicenter, phase 3 trial. Patients with resectable pancreatic cancer will be randomly assigned (1:1) to 8 cycles of neoadjuvant mFOLFIRINOX followed by surgery and 4 cycles of adjuvant…
- Conditions
- Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Adenocarcinoma
- Trial name
- PREOPANC-3 (NCT04927780)
- Testing
- Leucovorin Calcium, Fluorouracil, Irinotecan Hydrochloride
- Where
- 21 sites in Netherlands, Sweden
- Volunteers
- 378 people
- Sponsor
- Erasmus Medical Center
Type 2 Diabetes, Chronic Kidney Disease
Sweet & Sour: Dietary Acid Load in Type 2 Diabetes and Kidney Disease Across Sex and Ethnic Groups
Chronic kidney disease (CKD) is a common condition and a major global cause of illness and mortality. The most common cause of kidney damage is diabetes, a condition that disrupts metabolism, leading to increased risk of damage…
- Trial name
- Sweet & Sour (NCT07587918)
- Testing
- Low Dietary Acid Load
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Erasmus Medical Center
Acquired Brain Injury (Including Stroke)
Implementation of a Home-based Computerized Cognitive Rehabilitation Program for Patients With ABI
Rationale: Patients with acquired brain injury (ABI) may suffer from persistent cognitive deficits and/or subjective cognitive complaints, especially in the domains of attention and working memory.
- Trial name
- CoRe@Home (NCT06749197)
- Testing
- Rehacom
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Breast Fibrosis, Breast Cancer
An Integrated Optimization of Surgery and Radiotherapy Techniques to Improve Cosmetic Outcome and Quality of Life in Breast Conserving Therapy for Breast Cancer Patients (STARLINGS Study)
To assess the role of different combinations of (oncoplastic) surgery and radiotherapy techniques as risk factors for moderate to severe fibrosis and for moderate to poor cosmetic outcome.
- Conditions
- Breast Fibrosis, Breast Cancer, Breast Cancer Female, Breast Neoplasms
- Trial name
- STARLINGS (NCT05263362)
- Testing
- no intervention
- Where
- 4 sites in Netherlands
- Volunteers
- 775 people
- Sponsor
- Erasmus Medical Center
Renal Cell Carcinoma (RCC)
CBCT Guided Markerless SBRT for Renal Cell Cancer
This study aims to improve the treatment of kidney tumors using radiotherapy, by investigating whether kidney cancer can be more effectively irradiated with the help of new imaging techniques
- Trial name
- CT-STARRS (NCT07402109)
- Testing
- Additional radiation due to imaging
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Erasmus Medical Center
Emergency Medical Services, Airway Management
The Evaluation of Training an Emergency Reflex Action Drill in the Emergency Surgical Airway in Dutch Paramedics
The goal of this observational study is to learn about the effects of training an Emergency Reflex Action Drill (ERAD) for Emergency Surgical Airway (ESA) in Dutch paramedics.
- Conditions
- Emergency Medical Services, Airway Management, Cricothyroidotomy, Prehospital
- Trial name
- ERAD-ESA (NCT06645288)
- Testing
- Emergency Reflex Action Drill
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- Erasmus Medical Center
Effectiveness of Application Education Intervention, Noise Induced Hearing Loss
Prevention of Noise-Induced Hearing Loss in Primary Education
The goal of this randomized controlled trial is to evaluate the effectiveness of the educational program the HoorToren in promoting recreational safe listening behavior among Dutch primary school children in group 7 (aged 10-11…
- Conditions
- Effectiveness of Application Education Intervention, Noise Induced Hearing Loss, Behavior Change Interventions, Primary School Children
- Trial name
- NCT07513077
- Testing
- HoorToren educational package
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Cardiovascular Diseases, Cardiac Rehabilitation
OPTImizing CArdiac REhabilitation by REfining Sleep and STress
The primary objective of this project is to investigate the effectiveness and costs of integrating a behavioural program targeting sleep and stress (the RESST intervention) into cardiac rehabilitation (CR).
- Trial name
- OPTICARE-RESST (NCT06505109)
- Testing
- RESST
- Where
- 3 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Pseudomonas Aeruginosa, Colonization, Asymptomatic
Carbapenem-resistant Pseudomonas Aeruginosa: the SAMPAN Study.
Pseudomonas aeruginosa causes severe infections in hospitalized patients. The worldwide emergence of carbapenem-resistant P. aeruginosa (CRPA) makes infections by these pathogens almost untreatable.
- Conditions
- Pseudomonas Aeruginosa, Colonization, Asymptomatic, Nosocomial Infection
- Trial name
- SAMPAN (NCT05282082)
- Where
- 3 sites in Indonesia, Italy and 1 more
- Volunteers
- 2,105 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Overweight, Children
010Fit'R - Healthy Lifestyle Interventions for Children With Overweight
Overweight is a leading risk factor for non-communicable diseases. In the Netherlands, about 11% of children aged 4-12 years are overweight.
- Trial name
- 010Fit'R (NCT07419503)
- Testing
- 010 Fit'R intervention
- Where
- Netherlands
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Early Warning Score, Monitoring
Observational Study Evaluating the viQtor for Early Detection of Clinical Deterioration in Post-ICU Patients on General Wards
Rationale Following ICU discharge, intermittent vital sign monitoring may delay timely recognition of clinical deterioration and lead to unnecessary readmissions.
- Conditions
- Early Warning Score, Monitoring, Telemedicine-Based Education, Readmission
- Trial name
- ViQtor (NCT06815718)
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Erasmus Medical Center
Early Discharge, Telemedicine
Virtual Ward for Early Discharge in Patients Receiving Inpatient Care
This study evaluates the feasibility of providing hospital-level care at home for eligible patients through a Virtual Ward. Patients are discharged early from the hospital and monitored remotely using digital vital sign…
- Conditions
- Early Discharge, Telemedicine, Virtual Clinic, Hospital at Home
- Trial name
- VIP care (NCT06936891)
- Testing
- Virtual Ward
- Where
- Netherlands
- Volunteers
- 306 people
- Sponsor
- Erasmus Medical Center