Clinical trials: sponsored by Fondazione Don Carlo Gnocchi ETS
Focal Dystonia, Rehabilitation Exercise
Protocol in Musician's Focal Dystonia (MISA)
Musician's Focal Dystonia (MFD) is a task-specific movement disorder that impairs fine motor control during musical performance and may severely affect professional and amateur musicians.
- Conditions
- Focal Dystonia, Rehabilitation Exercise, Sensorimotor
- Trial name
- MISA (NCT07923799)
- Testing
- Modified Integrated Sensorimotor Approach (MISA)
- Where
- 2 sites in Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Caregiver Anxiety, Acquired Brain Injury
Comprehensive Assessment of Rehabilitation Experience Using the SAFE Scale
Patients with severe acquired brain injury (sABI) and disorders of consciousness (DoC) require intensive interdisciplinary rehabilitation involving healthcare professionals, patients, and family caregivers.
- Conditions
- Caregiver Anxiety, Acquired Brain Injury, Caregiver Satisfaction and Connectedness to Clinic, Disorders of Consciousness Due to Severe Brain Injury
- Trial name
- CARE-SAFE (NCT07912372)
- Testing
- Caregiver training and administration of SAFE scale, Standard clinical care
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cardiac Rehab, Heart Failure
The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure
The ITACARE-P CardioRehab Registry is a nationwide observational study conducted in Italy and coordinated by the Fondazione Don Carlo Gnocchi in Milan.
- Conditions
- Cardiac Rehab, Heart Failure, Coronary Disease, Heart Conditions
- Trial name
- CardioRehab (NCT07094737)
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Parkinson Desease, Mild Cognitive Impairment (MCI)
Cognitive Rehabilitation With Virtual Reality in Parkinson Disease
The OPERA Clinical Study is an interventional, single-arm, open-label pilot clinical study that aims to evaluate the usability of an innovative bio-cooperative robotic platform (PRoBio) for cognitive rehabilitation in patients…
- Trial name
- OPERA (NCT06920511)
- Testing
- Cognitve rehabilitation with virtual reality and robotic arm
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
Effect of High Intensity Training on Motor and Cognitive Functions
Fatigability is one of the most prevalent disorder in MS followed by walking, balance and cognitive disorders. However, there are few experimental studies on the effects of fatigability on balance and gait hampering the knowledge…
- Trial name
- FAST (NCT06219304)
- Testing
- Multimodal functional training, Usual care
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Study on the Effects of an EMG-controlled Functional Electrical Stimulator for Upper Limb for Post-stroke Patients
Upper limb disabilities are among the most debilitating issues after a cerebral stroke. One promising approach in motor rehabilitation is the use of functional electrical stimulation (FES).
- Trial name
- NCT06928857
- Testing
- EMG-based FES rehabilitation, Traditional rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cardiovascular Diseases, Diabete Type 2
EffectiVenEss of a Rehabilitation Treatment With Nordic Walking in obEse or oveRweight Patients
Nordic Walking (NW) is a biomechanically correct walking technique that originated in Finland in the 1930s as an off-season training method for cross-country skiers.
- Conditions
- Cardiovascular Diseases, Diabete Type 2, Overweight and Obesity
- Trial name
- VENERE (NCT05987410)
- Testing
- Nordic Walking (NW), Standard Rehabilitation (SR), Cardiological Counselling (CC)
- Where
- Italy
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Heart Transplant
Exercise aNd hEArt Transplant
Registry-based randomized clinical trial (RRCT) to assess the safety and efficacy of two different schemes of exercise training in patients who have recently undergone heart transplantation
- Trial name
- ENEA (NCT05824364)
- Testing
- telerehabilitation, rehabilomic
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cardiogenic Shock
Cardiac Rehabilitation in Patients Acutely Managed for Cardiogenic Shock (ENIGMA)
This is a prospective and retrospective multicentre study conducted under the scientific coordination of the IRCCS Fondazione Don Gnocchi and funded by the Italian Ministry of Health (PNRR-MCNT2-2023-12377767).
- Trial name
- ENIGMA (NCT06572826)
- Testing
- Cardiac Rehabilitation intervention
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury
Home-Based Exergame Motor-Cognitive Rehabilitation for Traumatic Brain Injury
The goal of this clinical trial is to evaluate the effectiveness of a home-based cognitive-motor telerehabilitation program in individuals with traumatic brain injury (TBI) following discharge from intensive inpatient…
- Trial name
- HOME-TBI (NCT07733336)
- Testing
- HOME-EXER telerehabilitation protocol, OUT-REHAB rehabilitation protocol
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
MCI, Mild Cognitive Impairment (MCI)
Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards
Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery.
- Conditions
- MCI, Mild Cognitive Impairment (MCI), Mild Cognitive Impairment, Cognitive Deficit
- Trial name
- COGinREHAB (NCT07731334)
- Testing
- Cognitive and clinical screening, Extended neuropsychological assessment, Blood biomarker sampling and APOE genotyping
- Where
- 3 sites in Italy
- Volunteers
- 384 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Rehabilitation With and Without Robot and Allied Digital Technologies in Stroke Patients
Rehabilitation after stroke often employs Robot and Allied Digital Technologies (RADTs), yet evidence on their effectiveness remains inconclusive due to study heterogeneity and limited sample sizes.
- Trial name
- StrokeFit4 (NCT06547827)
- Testing
- robotic rehabilitation, traditional rehabilitation
- Where
- 27 sites in Italy
- Volunteers
- 596 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Chronic Obstructive Pulmonary Disease (COPD), Idiopathic Pulmonary Fibrosis
New Diagnostic Approaches in the Management of Inflammatory Lung Diseases
Inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), are major causes of morbidity and mortality worldwide.
- Trial name
- ALPI (NCT07723638)
- Testing
- Integrated Precision Medicine Platform
- Volunteers
- 200 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
COPD, Idiopathic Pulmonary Fibrosis (IPF)
Identification of Diagnostic and Prognostic Biomarkers in the Pathological Continuum of Bronco Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis and Pulmonary Neoplasia
Primary Objective: To evaluate the association between inflammatory, immunological, genetic, and epigenetic biomarkers measured at enrollment and the clinical, functional, and phenotypic characteristics of patients with chronic…
- Conditions
- COPD, Idiopathic Pulmonary Fibrosis (IPF), Lung Cancer
- Trial name
- RESPIRO (NCT07707245)
- Testing
- Peripheral Blood Collection
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Heart Failure, Myocardial Infarction
Transcultural Digital Solutions in Phase III Cardiac Rehabilitation
Multicenter Prospective Controlled Randomized Trial, open-label, in patients with atherosclerotic cardiovascular disease (ASCVD) (acute coronary syndrome or chronic coronary syndrome and ischemic heart failure) and an approved…
- Trial name
- COMPASS (NCT07252856)
- Testing
- DEEPER
- Where
- 6 sites in Belgium, Italy and 2 more
- Volunteers
- 306 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Critical Illness, Post Intensive Care Syndrome (PICS)
Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)
This two-arm, parallel-group randomized clinical trial investigates the effectiveness of an additional telerehabilitation program compared with standard care in patients with Post-Intensive Care Syndrome (PICS).
- Conditions
- Critical Illness, Post Intensive Care Syndrome (PICS), Cardiopathy
- Trial name
- CARDIO-PICS (NCT07599306)
- Testing
- Tele-rehabilitation, Standard of Care
- Where
- Italy
- Volunteers
- 326 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Evaluation of a Haptic Glove for Assessing Tactile Perception in Post-Stroke Patients
The aim of the SCORES Haptic Glove Study is to assess the technical features, safety, and reliability of a sensor-equipped glove designed to evaluate tactile perception.
- Trial name
- SCORES-glove (NCT06643273)
- Testing
- Robotic rehabilitation, Conventional rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 126 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Validity and Responsiveness of the Fugl-Meyer Assessment in Subacute Stroke Patients
This prospective multicenter study evaluated the construct validity and responsiveness of the Fugl-Meyer Assessment (FMA) in individuals with subacute stroke undergoing inpatient rehabilitation.
- Trial name
- FMA_val_resp (NCT07508540)
- Where
- Italy
- Volunteers
- 135 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Lower Limb Amputation, Slip Perturbations
Pilot Study on the Evaluation of the Functionality, Safety and Reliability of New Tripping Devices for Lower Limbs.
The study aims to identify prognostic biomarkers of fall risk in patients with lower limb amputation
- Conditions
- Lower Limb Amputation, Slip Perturbations, Fall Risk
- Trial name
- MOTU++ pedane (NCT06883942)
- Testing
- prosthetic group performs the entire protocol with their own prosthesis, Experimental Group
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS