Clinical trials: sponsored by Fujian Medical University
AML, Adult
Biomarkers in Bone Marrow Supernatant for Predicting AML Chemosensitivity
Chemoresistance in acute myeloid leukemia (AML) is closely associated with the bone marrow microenvironment. Elevated levels of IL-6, leptin, fumarate, and other factors within the bone marrow microenvironment have been shown to…
- Trial name
- NCT07587944
- Where
- China
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Dementia
Dyadic Personalized Home-Based Activity Program for Mild-to-Moderate Dementia Patients Post-Discharge
This interventional study aims to evaluate the efficacy of a dyadic personalized home-based activity program in managing behavioral and psychological symptoms of dementia (BPSD) among home-dwelling people living with…
- Trial name
- NCT07081750
- Testing
- Dyadic personalized home-based activity program intervention, Routine care
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Fujian Medical University
Acute Myeloid Leukemia, Newly Diagnosed
Study of the Effectiveness and Safety of Daunorubicin /Idarubicin ± Silibinin in Treating Newly Diagnosed AML (Non-M3).
Silibinin is the major active component of silymarin, a commonly used hepatoprotective agent. It stabilizes hepatocyte membranes, preserves cellular integrity, and accelerates DNA synthesis in liver cells.
- Conditions
- Acute Myeloid Leukemia, Newly Diagnosed, Chemotherapy Effect
- Trial name
- AML (NCT07561892)
- Testing
- daunomycin/Idarubicin+ Silybinin, daunomycin/Idarubicin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University Union Hospital
Acute Myeloid Leukemia, Personalized Active Immunotherapy
Efficacy and Safety of Autologous Peptide-induced Active Immunity in AML Maintenance Therapy
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While approximately 70% of patients achieve complete remission (CR) with induction chemotherapy, traditional consolidation therapy (predominantly high-dose…
- Conditions
- Acute Myeloid Leukemia, Personalized Active Immunotherapy, Maintenance Therapy
- Trial name
- AML (NCT07551037)
- Testing
- Active Immunotherapy, after 6 courses of routine consolidation chemotherapy, during 6 courses of routine consolidation chemotherapy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fujian Medical University Union Hospital
Huntington Disease
Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease
The purpose of this research study is to determine the optimal pulse repetition frequency of low-intensity focused ultrasound that is safe and effective in improving motor symptoms in patients with Huntington's disease.
- Trial name
- NCT07513844
- Testing
- Low-Intensity Focused Ultrasound Stimulation（LIFU）
- Where
- China
- Volunteers
- 24 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Cardiovascular Diseases (CVD), Chronic Kidney Disease
Study on Construction of Whole Lifecycle Cohort, Big Data Management and Clinical Prognosis of Cardio-Renal-Metabolic (CKM) Syndrome
This is a single-center observational registry study aiming to establish a structured clinical and multimodal imaging database for cardiovascular-kidney-metabolic (CKM) populations and to support lifecycle follow-up and outcome…
- Conditions
- Cardiovascular Diseases (CVD), Chronic Kidney Disease, Metabolic Diseases, Cardiovascular-kidney-metabolic Syndrome
- Trial name
- CKM-LCBP (NCT07547098)
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Acute T Lymphoblastic Leukemia (T-ALL)
PD-1 Inhibitors +Venetoclax+CAG Regimens in R/R T-ALL
This prospective multicenter study evaluates the efficacy and safety of PD-1 inhibitor combined with venetoclax and HAG/CAG chemotherapy in refractory/relapsed T-ALL (R/R T-ALL).
- Trial name
- PD1-VEN-CAG (NCT07541755)
- Testing
- PD-1 Inhibitors
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University Union Hospital
Dentition Defect, Healing Abutment
Feasibility Study on the Application of Bionic Healing Abutments in Implant Impressions
The bionic healing abutment of the group's previous research results has both soft tissue shaping and impression taking functions, realizing the advantages of no need to dismantle the impression, simplifying clinical operation…
- Trial name
- NCT07514585
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Fujian Medical University
Hepatocellular Carcinoma (HCC)
Ultra-stable Iodized Oil-Chemo Embolization Seq Thermal Ablation in Early Liver Ca
Background: In the treatment of liver cancer, TACE (transarterial chemoembolization) combined with ablation is commonly used. The chemotherapeutic drug iodized oil emulsion prepared by the ultra-stable homogeneous mixture…
- Trial name
- NCT07493070
- Testing
- TACE combined with thermal ablation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fujian Medical University Union Hospital
Relapsed/Refractory CD19-positive B-ALL
Clinical Study of Universal CD19 CAR-γδ T Cell Infusion in the Treatment of Relapsed/Refractory Acute B Lymphoblastic Leukemia
This study is an open-label, single-arm clinical trial designed to evaluate the safety and tolerability of QH103 cell infusion in subjects with CD19-positive R/R B-ALL.
- Trial name
- NCT07491263
- Testing
- Cyclophosphamide, Fludarabine, QH103 Cell Injection
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Fujian Medical University
Prostate Cancer (Adenocarcinoma)
Rezvilutamide for High-Risk Prostate Cancer After Surgery
The goal of this clinical trial is to learn if Rezvilutamide works to treat high-risk prostate cancer in patients who have recently undergone surgery (radical prostatectomy). It will also learn about the safety of Rezvilutamide.
- Trial name
- NCT07444983
- Testing
- Rezvilutamide and Leuprorelin
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Fujian Medical University Union Hospital
Thyroid Cancer, Thyroid Neoplasms
Response to Neoadjuvant Treatment in Locally Advanced Thyroid Cancer
This multicenter observational study aims to evaluate the safety and efficacy of neoadjuvant therapy in patients with locally advanced thyroid cancer, focusing on imaging, biochemical, and pathological responses, as well as…
- Trial name
- NeoLATC (NCT07419932)
- Testing
- Multitarget Tyrosine Kinase Inhibitors, BRAF inhibitor dabrafenib and MEK inhibitor trametinib, RET Inhibitor
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Rectal Neoplasms
MRA Diameter as a Predictor for LLN Metastasis in Rectal Cancer.
This study aims to identify risk factors-including clinical and imaging indicators such as middle rectal artery (MRA) diameter-that may be associated with lateral lymph node metastasis (LLNM) in rectal cancer located below the…
- Trial name
- NCT07419516
- Testing
- No Intervention
- Where
- China
- Volunteers
- 690 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Esophageal Cancer, Recurrent Laryngeal Nerve
The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Minimally Invasive Esophagectomy
The goal of this clinical trial is to learn whether the application of indocyanine green near-infrared imaging system can accurately locate the recurrent laryngeal nerve (RLN) during lymph node dissection in esophageal cancer…
- Conditions
- Esophageal Cancer, Recurrent Laryngeal Nerve, ICG (Indocyanine Green), Lymph Node Dissection
- Trial name
- NCT07406815
- Testing
- ICG (Indocyanine Green)
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Temporomandibular Joint Disc Displacement
Accuracy of Digital Mandibular Repositioning in Occlusal Reconstruction for Patients With Disc Displacement
This study evaluates a new, individualized treatment for adolescents with temporomandibular joint disorders (TMD) caused by bilateral, reducible disc displacement.
- Trial name
- NCT07345104
- Testing
- Clinical Clicking Elimination Repositioning Splint, Adjustable Articulator Repositioning Splint, CAD-Designed Anatomical Repositioning Splint
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Fujian Medical University
Pulmonary Nodules, Ground-glass Opacity
Percutaneous Robotic Navigation Microwave Ablation Versus CT-guided Microwave Ablation in the Treatment of Pulmonary Nodules With Ground-glass Opacity
1. To compare the precision of robot-guided microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules. 2.
- Trial name
- NCT07389889
- Testing
- Robot, CT scan
- Volunteers
- 116 people
- Sponsor
- Fujian Medical University Union Hospital
Urologic Diseases
Evaluation of AI Large Models for Diagnosis and Treatment in Real-World Cases: Multicenter Retrospective Study
This multicenter retrospective study aims to evaluate the diagnostic and therapeutic performance of three large language models-ChatGPT, Gemini and Deepseek-using 800 archived inpatient medical records from urology departments…
- Trial name
- NCT07378358
- Testing
- Large Language Model Assessment (ChatGPT, Gemini, DeepSeek)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Refractory Schizophrenia
Deep Brain Stimulation of the Nucleus Accumbens and Anterior Limb of the Internal Capsule in the Treatment of Refractory Schizophrenia
Schizophrenia is a lifelong psychiatric disorder with a prevalence rate of 0.559% and a lifetime prevalence rate of 0.588% among Chinese adults.
- Trial name
- NCT07369401
- Testing
- Deep Brain Stimulation
- Volunteers
- 10 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Recurrent/Refractory B-cell Lymphoma
Clinical Study of Universal CD19 CAR-γδT Cell Injection in the Treatment of Adult Relapsed/Refractory B-cell Lymphoma
This study is an open-label, single-arm clinical trial designed to evaluate the safety and tolerability of QH103 cell injection solution in adult subjects with relapsed/refractory CD19-positive B-cell lymphoma.
- Trial name
- NCT07367685
- Testing
- QH103 Cell Injection, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The Second Affiliated Hospital of Fujian Medical University
Prostate Cancer (Adenocarcinoma)
The Value of GRPR PET Imaging for Diagnosis and Staging in Prostate Cancer
The gastrin-releasing peptide receptor (GRPR) is highly expressed in prostate cancer (77%-100%). Numerous studies have confirmed that GRPR PET imaging has emerged as a significant molecular imaging modality in prostate cancer…
- Trial name
- NCT07363382
- Testing
- 68Ga-G21, 68Ga-G23
- Where
- China
- Volunteers
- 6 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University