Clinical trials: sponsored by Georgetown University
Breast Cancer
TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer
This is a multi-institutional pilot trial for patients with advanced breast cancer. The trial is designed to assess the safety and tolerability of induction talazoparib followed by combination of talazoparib and avelumab.
- Trial name
- NCT03964532
- Testing
- Talazoparib, Avelumab
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Georgetown University
Cervical Cancer, Metastatic Cervical Cancer
Pembrolizumab and Lenvatinib in Advanced Cervical Cancer
This is a phase II trial of combination therapy of pembrolizumab and lenvatinib in patients with locally advanced or metastatic cervical cancer that had failed first line of therapy.
- Trial name
- NCT04865887
- Testing
- Pembrolizumab, Lenvatinib
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Georgetown University
Non-squamous Non-small-cell Lung Cancer
Tiragolumab With Atezolizumab Plus Bevacizumab in Previously-Treated Advanced Non-squamous NSCLC
To evaluate the efficacy of tiragolumab with atezolizumab and bevacizumab in previously-treated advanced non-squamous NSCLC.
- Trial name
- NCT04958811
- Testing
- Tiragolumab, Atezolizumab, Bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Georgetown University
Prostate Cancer, Localized Prostate Carcinoma
MRI-based Focal Intraprostatic Simultaneous Integrated Boost (SIB) Intensification With De-escalated Adaptive-risk SBRT for Patients With Low to Intermediate Risk Prostate Cancer
The goal of this clinical trial is to determine the safety of stereotactic body radiation therapy (SBRT) microboost technique in patients with low to intermediate risk prostate cancer.
- Trial name
- MIDAS (NCT07644598)
- Testing
- Microboost SBRT, Whole gland de-escalation 30 Gy, Whole gland de-escalation 35 Gy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Georgetown University
Safety Issues, Pain
Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis
Chronic pancreatitis is a rare but debilitating condition associated with chronic abdominal pain, diarrhea, diabetes, and an 8-fold increased risk for the development of pancreatic cancer.
- Conditions
- Safety Issues, Pain, Pancreas Fibrosis
- Trial name
- ProCP (NCT05551858)
- Testing
- Proglumide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Georgetown University
Anxiety Disorders, Generalized Anxiety Disorder
Mindful Self-Compassion for Anxiety Disorders and Depression
The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders…
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Social Phobia
- Trial name
- NCT05671419
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgetown University
HIV-1-infection, Metabolic Syndrome
Healthy Lifestyles: A Home Based Physical Activity Intervention in Persons Living With HIV
This study is being done to understand how a physical activity walking intervention affects metabolic parameters (i.e., blood sugar, cholesterol, certain body measurements) in people with and without HIV.
- Trial name
- NCT05896852
- Testing
- physical activity
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Alzheimer's Disease
Impact of Nilotinib on Safety, Biomarkers and Clinical Outcomes in Mild to Moderate Alzheimer's Disease
The investigators hypothesize that Nilotinib will be safe in individuals with mild to moderate AD. Specifically, investigators hypothesize that low daily oral doses of Nilotinib will lead to CSF penetration, CNS Abl inhibition…
- Trial name
- AD (NCT02947893)
- Testing
- Nilotinib Capsule(s) Once a Day by Mouth
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Georgetown University
Dementia With Lewy Bodies
Impact of Bosutinib on Safety, Tolerability, Biomarkers and Clinical Outcomes in Dementia With Lewy Bodies
This study evaluates the effect of Bosutinib (Bosulif,Pfizer®) in the treatment of patients with Dementia with Lewy Bodies. Half participants will receive 100 mg of Bosutinib , while the other half will receive placebo.
- Trial name
- NCT03888222
- Testing
- Bosutinib Oral Tablet
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Georgetown University
Mental Health
Does Social Media Impact Adolescent Mental Health?
The mental health of adolescents in the United States has seen a steep decline, roughly coinciding with the increasing popularity of social media and smartphones.
- Trial name
- NCT06049888
- Testing
- Restricted Social Media
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Pancreatic Ductal Adenocarcinoma, Refractory Non-Small Cell Lung Cancer
Anti-CD38 Antibody With KRAS Vaccine and Anti-PD-1 Antibody in Subjects With Pancreatic Ductal Adenocarcinoma and Refractory Non-Small Cell Lung Cancer
The goal of this clinical trial is to test the safety and tolerability of anti-CD38 monoclonal antibody (mAb), daratumumab, in combination with KRAS vaccine (Targovax TG-01/Stimulon QS-21) when given with anti-PD-1 (programmed…
- Trial name
- DARANIVOVAX (NCT06015724)
- Testing
- Daratumumab, KRAS vaccine, Nivolumab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Georgetown University
Extensive-stage Small-cell Lung Cancer
MGC018 in Patients With Relapsed or Refractory Extensive-Stage Small-Cell Lung Cancer
The goal of this clinical trial is to test MGC018 in patients with relapsed or refractory Extensive-Stage Small-Cell Lung Cancer (ES-SCLC).
- Trial name
- MGC018-SCLC (NCT06227546)
- Testing
- MGC018
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Georgetown University
Parkinson Disease, Parkinsons Disease With Dementia
Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder causing motor and non-motor symptoms. PD is characterized by death of dopaminergic (DA) neurons in the substantia nigra (SN) pars compacta and…
- Trial name
- PD Nilotinib (NCT02954978)
- Testing
- Nilotinib 150mg oral capsule [Tasigna], Nilotinib 300mg oral capsule [Tasigna]
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Georgetown University
Dementia With Lewy Bodies
Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies
Dementia with Lewy Bodies (DLB) is an alphasynucleinopathy and the second most common form of dementia in the elderly. DLB shares striking neuropathological and clinical similarities with both Parkinson's disease (PD) and…
- Trial name
- NCT04002674
- Testing
- Nilotinib Oral Capsule
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Georgetown University
Metastatic Pancreatic Cancer
Proglumide and Chemotherapy for Metastatic Pancreatic Cancer
This is a Phase 2 study with an open labelled lead-in study to approximately treat 30 patients [6 subjects for Lead-in and 24 for Phase 2] enrolled with metastatic pancreatic cancer with combination therapy using standard of care…
- Trial name
- ProGem (NCT05827055)
- Testing
- Gemcitabine, Nab paclitaxel, Proglumide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgetown University
Dementia With Lewy Bodies
K0706 for Patients Diagnosed With Dementia With Lewy Bodies
This study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB.
- Trial name
- NCT03996460
- Testing
- 192 mg powder of K0706, 384 mg powder of K0706
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Georgetown University
Breast Cancer Risk
Peer Support For Young Adult Women With High Breast Cancer Risk
This trial will recruit young adult female relatives (YARs) of male or female carriers of BRCA1/2. YARs who consent to participate will be randomized to either a 3-session peer coach-led telephone counseling intervention or usual…
- Trial name
- NCT04248257
- Testing
- PeACE, Community peer coaching
- Where
- 6 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Prostate Cancer Patients, Hereditary Cancer
Expanding Genetic Access for Prostate Cancer Survivors
The goal of this study is to increase genetic education and genetic testing for hereditary cancer risk among prostate cancer survivors. The study will: Test the effectiveness of a digital guide (DG+) vs. print guide (Print+) vs.
- Conditions
- Prostate Cancer Patients, Hereditary Cancer, Genetic Testing
- Trial name
- ENGAGE (NCT07618520)
- Testing
- Print Genetic Education Guide, Digital Guide Genetic Education Guide, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Georgetown University
Breast Cancer Screening, Colon Cancer Screening
Bundled Cancer Screening and Genetic Services Navigation
The goal of this study is to test bundled familial cancer risk assessment + multicancer (colorectal + breast) vs. single (breast) cancer navigation, using a wait list control for colorectal cancer screening referral and…
- Conditions
- Breast Cancer Screening, Colon Cancer Screening, Genetics Predisposition
- Trial name
- NCT07228000
- Testing
- Breast cancer screening navigation, Multicancer screening navigation, Usual care genetics referral
- Where
- 2 sites in United States
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Anxiety Disorders, Generalized Anxiety Disorder
Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method
The study will compare the delivery of an 8-week Mindful Self-Compassion training, in-person against video-conference, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety…
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT07028216
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Georgetown University