Clinical trials: open to volunteers, sponsored by IRCCS Eugenio Medea
Developmental Dyslexia, Reading Problem
Personalization of Visual Characters and Text-to-Speech (TTS) to Support Learning in Students With Reading Difficulties
Previous research has shown the importance of font type, size and spacing to facilitate text reading in dyslexia. A special automatized procedure was designed to select the most favorable parameters for both text visualization…
- Trial name
- NCT06947512
- Testing
- Seleggo Test
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Developmental Dyslexia, Developmental Language Disorder
Dynamic Assessment of the Risk for Language and Reading Disorders in Monolingual and Multilingual Children
The project represents the completion of a part of the recently concluded European project MultiMind, in which a computer platform called MuLiMi was developed and validated.
- Trial name
- NCT06937255
- Testing
- computerized Dynamic Assessment
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Friedreich's Ataxia, Motor Disorders
Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.
Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG).
- Trial name
- CONNETTOMA (NCT07095062)
- Testing
- HD-EEG recordings, combined with cognitive and motor assessment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Spinal Cord Injury, Stroke
Investigating Techniques to Enhance the Sense of Embodiment in Immersive Virtual Reality
Embodiment is an important aspect of virtual reality because it affects how natural and engaging the experience feels and can influence performance and learning in VR-based applications, including rehabilitation [McAnally \&…
- Conditions
- Spinal Cord Injury, Stroke, Healthy
- Trial name
- NCT07870044
- Testing
- Immersive Virtual Reality Embodiment Manipulations
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy (CP), Brain Injuries
Acceptability of Paediatric Wrist Orthoses Through Co-design
The goal of this pilot interventional study (pre-post design) is to learn if a co-designed wrist-hand orthosis can improve acceptability compared to a conventional orthosis in children aged 6 to 14 years with neuromotor disorders…
- Conditions
- Cerebral Palsy (CP), Brain Injuries, Neuromotor Dysfunction
- Trial name
- NCT07861958
- Testing
- Orthosis acceptability
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy (CP)
Clinical Improvement Due to the Home Use of Agilik in Children With Cerebral Palsy
The goal of this clinical trial is to learn if a two month training with the Agilik powered orthosis improves the knee extension or the endurance in pediatric patients with Cerebral palsy and a crouch gait.
- Trial name
- Agilik@home (NCT06622655)
- Testing
- Powered orthosis
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Eugenio Medea
Neuromotor Impairments
AI-based Model for Rehabilitation Engagement and Motor Performance Evaluation in Pediatric Patients: A Pilot Study
What is the purpose of this study? This study aims to evaluate the usability and feasibility of an artificial intelligence-based model designed to monitor in real-time the engagement and motor performance of pediatric patients…
- Trial name
- AI-REMAP (NCT07664033)
- Testing
- Artificial Intelligence Model for Rehabilitation Engagement Monitoring
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Eugenio Medea
Genetic Syndrome
I-TOPS With Patients With Genetic Syndrome SYN-TOPS
Genetic syndromes involving the central nervous system are often associated with cognitive, behavioral and communication difficulties that negatively impact adaptive functioning and quality of life.
- Trial name
- SYN-TOPS (NCT07563218)
- Testing
- Italian Tailored Online Problem-Solving (I-TOPS)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Eugenio Medea
Neurodevelopmental Disorder (Diagnosis)
Transdiagnostic Dimensional Profiling of Neurodevelopmental Disorders
In recent years, the growing awareness of the multifactorial nature of neurodevelopmental disorders has stimulated interest in transdiagnostic approaches aimed at investigating underlying etiological mechanisms beyond traditional…
- Trial name
- RDoC-CRAB (NCT07544199)
- Testing
- Neuropsychological assessment
- Volunteers
- 300 people
- Sponsor
- IRCCS Eugenio Medea
Language Development, Language Development Disorders
Cortical Tracking of Speech in the First Year of Life
The goal of this observational study is to investigate early neural mechanisms underlying the processing of spoken language, specifically the phenomenon of cortical tracking, and to determine whether these mechanisms can serve as…
- Conditions
- Language Development, Language Development Disorders, Infant Development, Infant Developmental Assessment
- Trial name
- NCT07531706
- Testing
- Electrophysiological recording, Behavioral Assessment
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder
Sleep Disturbance in Subjects With Autism Spectrum Disorders (ASD) in Preschool Age (18-60 Months)
An observational study is one that aims to collect data from routine clinical practice, without altering a patient's standard diagnostic and therapeutic pathway (no additional instrumental or laboratory tests beyond those…
- Trial name
- NCT07470138
- Testing
- follow up
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Eugenio Medea
Adverse Childhood Experiences, Developmental Risk
Growing Up in Multifactorial Risk Conditions
The perinatal period brings significant physiological and emotional changes in mothers, linked to pregnancy, childbirth, and caring for a newborn.
- Conditions
- Adverse Childhood Experiences, Developmental Risk, Psychomotor Development Disorders, Neurodevelopmental Disorders
- Trial name
- CORE (NCT07477899)
- Testing
- Home visiting programme
- Where
- Italy
- Volunteers
- 352 people
- Sponsor
- IRCCS Eugenio Medea
Stair Climbing, Instrumentation
Implementation and Validation of Instrumented Stair Climb Test
The aim of this study is to design an instrumented test for the evaluation of the climb of stairs. In particular, the main purpose is to characterize and compare the performance of subjects, both pediatrics and adults, with…
- Conditions
- Stair Climbing, Instrumentation, Test
- Trial name
- SCTS (NCT06999850)
- Testing
- Instrumented Stair Climb Test, Walk Test, Repaeted Instrumented Stair Climb Test
- Where
- 3 sites in Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Pregnancy and Medically Assisted Reproduction
Antenatal Stress and Infants In MAR
The goal of this observational longitudinal study is to examine the association between prenatal psychological and biological stress and neonatal health outcomes in couples who conceived through medically assisted reproduction.
- Trial name
- SARA (NCT07408453)
- Testing
- Diagnostic procedures
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder
Characterization of (A)Typical Sensorimotor Pathways in Individuals With Autism
The goal of this interventional study is to understand whether sensorimotor skills could represent an endophenotype for autism, i.e.
- Trial name
- MovAUT (NCT07389720)
- Testing
- clinical assessment, Neuropsychological examination, Neurophysiological evaluation
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Muscular Dystrophies, Myopathies
Observational Study to Observe Variations of Gait Parameters in Patients With Neuromuscular Diseases
This study has the general objective of observing walking parameters during a clinical test to objectively estimate fatigue in patients with neuromuscular diseases.
- Conditions
- Muscular Dystrophies, Myopathies, Spinal Muscular Atrophy (SMA), Charcot Marie Tooth Disease
- Trial name
- NCT06666816
- Testing
- inapplicable
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Emotional Dysregulation, Externalizing Problems
Assessing Real Life Effectiveness of Treatment in Neurodevelopmental Disorders
The goal of this observational study is to learn if and how pharmacological and psychotherapeutic group treatments can treat clinical symptoms of children and adolescent patients with ADHD.
- Conditions
- Emotional Dysregulation, Externalizing Problems, Oppositional Defiant, Conduct Disorder
- Trial name
- ALERT (NCT07273695)
- Testing
- methyphenidate, Group psychological treatment
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Eugenio Medea
Neurological Impairments, Genetic Syndrome
Speech Therapy and Parenting for Early Socio-communicAtive sKills
Every year, millions of children are diagnosed with neurodevelopmental disabilities. This term covers a wide range of conditions, from genetic syndromes to brain injuries such as cerebral palsy.
- Conditions
- Neurological Impairments, Genetic Syndrome, Neurodevelopmental Disability, Developmental Delays
- Trial name
- SPEAK (NCT06666777)
- Testing
- Intervention focused on intersubjective prelinguistic and socio-communicative skills, Standard speech therapy intervention
- Where
- 9 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy (CP)
Cortical Correlates of Spatial Navigation Skills in an Immersive Virtual Reality Environment
The goal of this study is to investigate the neural mechanisms that undergoes spatial navigation skills in children/adolescents aged between 8 and 17 years.
- Trial name
- NCT06710301
- Testing
- Preliminary assessment, Navigation task with EEG recording
- Where
- 2 sites in Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Duchenne / Becker Muscular Dystrophy
Transition to Adulthood in People With Muscular Dystrophy
The study will involve boys with Duchenne Muscular Dystrophy (DMD), from adolescence to adulthood living in Italy, and their families/ caregivers.
- Trial name
- TAMDY (NCT07101185)
- Testing
- VIRTUAL REALITY
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Eugenio Medea