Clinical trials: sponsored by IRCCS San Raffaele
Stroke, Sabacute Stroke
Bilateral Robot-assisted Upper Extremity Rehabilitation on Motor Recovery in People With Subacute Stroke
The goal of this clinical trial is to study the clinical effects of a robotic rehabilitation treatment through a bilateral exoskeleton (Bilateral Robot-Assisted Therapy-BRAT) during standard rehabilitation, on motor recovery…
- Trial name
- BILAX (NCT06906588)
- Testing
- Experimental, Control
- Where
- 3 sites in Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele Roma
HIV, Antiviral Agents
Antiviral Long Acting Drugs Landing in People Living With HIV
This is a monocentric, prospective, double-arm, randomized, open-label, implementation-effectiveness hybrid type III study aimed at comparing hospital-based and home-based administration of CAB LA + RPV LA treatment for…
- Trial name
- ALADDIN (NCT06468995)
- Testing
- Surveys completion, Home administration of CAB+RPV, Hospital administration of CAB+RPV
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Parkinson Disease
Upper Limb Rehabilitation in People With Parkinson's Disease:
This study evaluates the effectiveness of upper limb rehabilitation using an end-effector robotic device with exercises designed to improve movements, strength, and coordination of the shoulder, elbow, and wrist in patients with…
- Trial name
- MOTORPARK (NCT06906679)
- Testing
- Experimental Group, control group
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS San Raffaele Roma
Hip Replacement, Total
Balance Rehabilitation Based on Serious Games
The effects of new technologies, particularly exergames, on the rehabilitation process of patients with hip arthroplasty have not yet been verified.
- Trial name
- BERTHA (NCT06908564)
- Testing
- Experimental: Interactive balance rehabilitation based on serious games., Active Comparator: conventional balance rehabilitation without the use of technological devices.
- Where
- 2 sites in Italy
- Volunteers
- 53 people
- Sponsor
- IRCCS San Raffaele Roma
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Stroke, Brain Injuries, Traumatic
Gait Training Through a Novel Over-ground Wearable Robotic System in People With Pyramidal Hemisyndromes
Over-ground exoskeletons for gait rehabilitation are studied enough in people suffering spinal cord injury, and its clinical use is escalating in the industrialized countries.
- Conditions
- Stroke, Brain Injuries, Traumatic, Brain Tumor Benign
- Trial name
- GAITGO (NCT04559724)
- Testing
- Indego Therapy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele Roma
Clear Cell Renal Cell Carcinoma, VHL Syndrome
Overtaking Intra and Inter Tumoral Heterogeneity In Von Hippel-Lindau Related Renal Cancer
The goal of this study is to comprehensively map intra and inter tumor heterogeneity of ccRCC in VHL patients through the use of imaging, molecular biology and genomics techniques.
- Trial name
- ITHORinVHL (NCT06195150)
- Testing
- Blood collection
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- IRCCS San Raffaele
Neurodevelopmental Disorder (Diagnosis), Feeding Disorder
Feeding Disorders in Children
Pediatric Feeding Disorders (PFDs) are conditions characterized by persistent difficulties in food intake, commonly manifesting as food selectivity, food refusal, and dysfunctional mealtime behaviors.
- Conditions
- Neurodevelopmental Disorder (Diagnosis), Feeding Disorder, ARFID
- Trial name
- FEEDING (NCT07431671)
- Testing
- Interdisciplinary intervention, Standard rehabilitation program
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS San Raffaele Roma
Stroke, Upper Extremity Paresis
The Efficacy of Upper Limb Rehabilitation With Exoskeleton in Patients With Subacute Stroke.
Loss of arm function is a common and distressing consequence of stroke. Neurotechnology-aided rehabilitation could be a promising approach to accelerate the recovery of upper limb functional impairments.
- Trial name
- PowerUPS-REHAB (NCT04697368)
- Testing
- Exoskeleton-Assisted Upper Limb Rehabilitation, Traditional Upper Limb Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 94 people
- Sponsor
- IRCCS San Raffaele Roma
Down Syndrome, Hemiparesis
Kinematic Analysis of Manual Dexterity
The following study aims to standardize the instrumented BBT for the objective evaluation of upper limb joint kinematics using MoCap on a population of healthy subjects between 4 and 18 years of age.
- Conditions
- Down Syndrome, Hemiparesis, Healthy Subjects
- Trial name
- SUPERFUN (NCT07875127)
- Testing
- Inertial Measurement Unit and Box and Block test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Insomnia Due to Anxiety and Fear
The Impact of Attentive System on Sleep Reactivity
Sleep Reactivity is defined as the degree to which a given amount of stress disrupts the sleep system, and it is consistent over time and across different type of stimuli.
- Trial name
- SREEG (NCT06694818)
- Testing
- trauma film paradigm
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis, Functional Neurological Disorders
Bridging Gaps in the Multidimensional Assessment and Management of Overlapping Symptoms in Multiple Sclerosis and Functional Motor Disorders: Prevalence and Rehabilitation Effectiveness
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system that may cause a broad range of motor and non-motor symptoms.
- Trial name
- NCT07856485
- Testing
- Functional Motor Disorder-Specific Multidisciplinary Rehabilitation, Conventional Multiple Sclerosis Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 192 people
- Sponsor
- IRCCS San Raffaele
Fibromyalgia
Psychologically Informed Telerehabilitation for Fibromyalgia
Fibromyalgia is a long-term condition that can cause widespread pain, fatigue, sleep problems, difficulties with concentration, and limitations in daily activities.
- Trial name
- FibroPIPT (NCT07865403)
- Testing
- Online Psychologically-Informed Physical Therapy, Paper-based booklet
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- IRCCS San Raffaele Roma
Age-Related (Dry) Macular Degeneration, Age-Related Macular Degeneration (AMD)
MIND-AMD Study: a Multidisciplinary Investigation of Neuroretinal Damage in Age-related Macular Degeneration.
Age-related macular degeneration (AMD) is the major cause of legal blindness in developed countries. Intermediate AMD represents the most frequent stage.
- Conditions
- Age-Related (Dry) Macular Degeneration, Age-Related Macular Degeneration (AMD), AMD Population - Intermediate or Advanced AMD, AMD and Macular Edema
- Trial name
- MIND-AMD (NCT07847151)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pancreatic Diseases
Feasibility of a 4-Week Intensive Postoperative Multimodal Rehabilitation Program in Complicated Patients After Proximal Pancreatectomy: A Prospective Single-Cohort Study
The REACT study is a prospective, single-center, single-cohort study designed to evaluate the feasibility of a 4-week intensive multimodal postoperative rehabilitation program in patients who develop severe complications after…
- Trial name
- REACT (NCT07768384)
- Testing
- Multimodal Postoperative Rehabilitation Program
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele
Mental Health, Cancer
ImprovINg the TIMEly Diagnosis and Treatment of Cancer and Cardio-metabolic Diseases in People With Mental Disorders: Reducing Health Disparities Through Integrated Care
One in five people in Italy has a mental disorder, with depression being the most common and schizophrenia the most severe. People with mental illness have a higher risk of cardio-metabolic and oncologic comorbidities.
- Conditions
- Mental Health, Cancer, Cardiometabolic Diseases
- Trial name
- IN-TIME (NCT07843433)
- Testing
- Not applicable - observational study
- Volunteers
- 120 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer, Pancreas Neoplasm
Radiology Registry on Pancreatic Malignancies
The purpose of this study is to collect all radiological data which evaluated with clinical data may help assess malignancy and prognosis of pancreatic disease.This registry aims to collect retrospective data from 2014 and…
- Conditions
- Pancreatic Cancer, Pancreas Neoplasm, Pancreas Disease, Pancreas Cyst
- Trial name
- RadonPams (NCT05714111)
- Testing
- Radiology evaluations and interventions
- Where
- Italy
- Volunteers
- 1,300 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
MR Radiomic Features in Prostate Cancer
A combination of correct interpretation of imaging and biopsy has given promising results in terms of detecting clinically significant cancer at radical prostatectomy.
- Trial name
- NCT04219059
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Locally Advanced Rectal Carcinoma
Radiological Markers in Locally Advanced Rectal Cancer
The goal of this observational study is to evaluate the prognostic significance of radiological markers, including the Likert Score derived from diffusion-weighted MRI (DWI), in patients with locally advanced rectal cancer (LARC)…
- Trial name
- LARC (NCT06843655)
- Where
- Italy
- Volunteers
- 179 people
- Sponsor
- IRCCS San Raffaele
Endometrium Cancer
Stratifying Endometrial Cancer Patients Using a PET/MRI Prognostic Model
Endometrial cancer (EC) is the most common gynecological malignancy in high-income countries. Prognosis and treatment are dictated by cancer histological subtype and grade coupled with surgical staging as described by Surgical…
- Trial name
- NCT04212910
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- IRCCS San Raffaele