Clinical trials: sponsored by IRCCS San Raffaele
Age Related Macular Degeneration
Intravitreal Bevacizumab for Low Vision in Neovascular Age-related Macular Degeneration (AMD)
The purpose of this study is to compare the effectiveness of intravitreal bevacizumab injection (IVBI) with respect to simple observation in patients with subfoveal choroidal neovascularisation (CNV) secondary to age-related…
- Trial name
- LOW-VISION (NCT01327222)
- Testing
- Bevacizumab
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Aneurysm
Subthreshold Laser Treatment Versus Threshold Laser Treatment for Symptomatic Retinal Arterial Macroaneurysm
Best treatment option of retinal arterial macroaneurysm is still controversial. A recent publication has shown that subthreshold laser treatment can be beneficial in improving visual acuity in eyes with symptomatic retinal…
- Trial name
- RAM-SUB (NCT01301326)
- Testing
- subthreshold and threshold laser treatment, Threshold laser treatment
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type 1, Insulin Pump, Programmable
Carbohydrate Counting in Adults With Type 1 Diabetes Treated With Continuous Subcutaneous Insulin Infusion
The investigators postulate that carbohydrate (CHO) counting in adult patients with type 1 diabetes mellitus (T1DM) treated with continuous subcutaneous insulin infusion (CSII) may improve glycemic control, glycemic variability…
- Trial name
- GIOCAR (NCT01173991)
- Testing
- Carbohydrate counting training
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- IRCCS San Raffaele
Atrial Fibrillation
A Trial of Circumferential Pulmonary Vein Ablation (CPVA) Versus Antiarrhythmic Drug Therapy in for Paroxysmal Atrial Fibrillation (AF)
Background: Circumferential pulmonary vein ablation (CPVA) has been safely and effectively performed for treating paroxysmal atrial fibrillation (PAF); however, its safety and efficacy, as compared with those of antiarrhythmic…
- Trial name
- APAF2 (NCT00340314)
- Testing
- Circumferential Pulmonary Vein Ablation, Antiarrhythmic Drug Therapy
- Where
- Italy
- Volunteers
- 198 people
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type 1
Pre Transplant Rapamycin Treatment in Islet Transplantation Alone
Numerous changes to the original Edmonton protocol have been proposed in the attempt of improving the still unsatisfactory long-term function of ITA.
- Trial name
- ITA-Rp (NCT01060605)
- Testing
- rapamycin
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- IRCCS San Raffaele
Leukemia, Chronic Myeloid Leukemia
Clinical Trial to Evaluate the Safety and Efficacy of Treosulfan Based Conditioning Prior to Allogeneic Haematopoietic Stem Cell Transplantation (HSCT)
This is a multicentric, non-randomized, non-controlled open-label phase II trial to evaluate the safety and efficacy of treosulfan in a combination regimen with fludarabine as conditioning therapy prior to allogeneic stem cell…
- Conditions
- Leukemia, Chronic Myeloid Leukemia, Myelodysplastic Syndrome, Diffuse Large Cell Lymphoma
- Trial name
- AlloTreo (NCT00598624)
- Testing
- Treosulfan IV
- Where
- 12 sites in Italy
- Volunteers
- 175 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease
Evaluation Rehabilitation on Glycometabolic State in Non-Diabetic Coronary Artery Disease (CAD) Patients
The purpose of this study is to evaluate the effects of an intensive Cardiac rehabilitation program on glucose metabolism of non-diabetic coronary artery disease patients.
- Trial name
- NCT00917930
- Testing
- physical training
- Sponsor
- IRCCS San Raffaele
Metabolic Syndrome, Impaired Glucose Tolerance
Prevention of Type 2 Diabetes Mellitus by L-Arginine in Patients With Metabolic Syndrome
Aim The principal objective of this project is: To evaluate the efficacy of long term (18 months) L-Arginine therapy in preventing or delaying clinical onset of type 2 diabetes mellitus in subjects with impaired glucose tolerance…
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Insulin Resistance, Endothelial Dysfunction
- Trial name
- L-arginine (NCT00917449)
- Testing
- L-arginine
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
HIV Infections, Hepatitis C
Lopinavir/Ritonavir Monotherapy Versus Standard Highly Active Antiretroviral Therapy (HAART) in HIV/HCV Coinfected Patients Starting Treatment With Anti-Hepatitis C Virus (HCV) Therapy
The purpose of this study is to evaluate if the combination of Lpv/r monotherapy and anti-HCV drugs does not match with additional toxicity induced by the association of HAART and Peg-IFN + ritonavir in HIV/HCV coinfected…
- Trial name
- NCT00437684
- Testing
- LPV/r, PEG-IFNa 2a, Ribavirin
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
HIV Infections, Hepatitis C
Lopinavir/Ritonavir Monotherapy Versus Standard Highly Active Antiretroviral Therapy (HAART) in HIV/HCV Coinfected Antiretroviral (ARV) Naive Patients Starting Treatment With Anti-HCV Therapy
The purpose of this study is to evaluate if the combination of Lpv/r monotherapy and anti-HCV drugs does not match with additional toxicity induced by the association of HAART and Peg-IFN + ritonavir in patients naive for HIV and…
- Trial name
- NCT00437476
- Testing
- LPV/r, Nucleoside Reverse Transcriptase Inhibitors, PEG-IFNa 2a
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Congestive Heart Failure
Testosterone Improves Exercise Oxygen Uptake, Insulin Resistance and Muscle Strength in Elderly Patients With Chronic Heart Failure
Background: Patients with congestive heart failure (CHF) show muscle mass wasting and decreased testosterone levels. Long-term testosterone supplementation improves walking distance and glucose metabolism of patients CHF.
- Trial name
- NCT00512408
- Testing
- testosterone
- Where
- Italy
- Sponsor
- IRCCS San Raffaele
Chronic Heart Failure, Hypertension
Nebivolol Versus Carvedilol in Patients With Heart Failure
BACKGROUND Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (CHF)…
- Trial name
- NCT00511888
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS San Raffaele
Severe Combined Immunodeficiency Syndrome
Gene Therapy for ADA-SCID
This study investigated the safety and efficacy of different gene therapy approaches for Severe Combined Immunodeficiency (SCID) caused by the deficiency of adenosine deaminase (ADA) enzyme.
- Trial name
- NCT00599781
- Testing
- gene transduced PBL and/or gene transduced HSC
- Volunteers
- 8 people
- Sponsor
- IRCCS San Raffaele
Tumors
Laparoscopic Liver Resection
The aim of this study is to evaluate the feasibility and safety of laparoscopic liver surgery.
- Trial name
- NCT00553033
- Testing
- Laparoscopic liver surgery
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele
Colorectal Liver Metastases
Preoperative Hepatic Arterial Infusion Chemotherapy
To assess the feasibility and results of liver resection after preoperative hepatic artery infusion (HAI) chemotherapy with FUDR.
- Trial name
- NCT00522509
- Testing
- Floxuridine FUDR
- Where
- Italy
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type 2
Screening for Undiagnosed Type 2 Diabetes in New Classes of Subjects at High Risk
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and…
- Trial name
- NCT00520962
- Where
- Italy
- Volunteers
- 1,997 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diabetes
Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics
chronic PDE5-Inhibition improves endothelial function in diabetics
- Trial name
- NCT00420901
- Testing
- sildenafil
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Cardiovascular Disease
Prevention of Cardiac and Vascular Events in Patients With NGT/IGT.
Impaired glucose tolerance or mild glucose elevations in the non-diabetic range are associated with increased cardiovascular disease and recent studies suggested the need to detect these glucose abnormalities early in the…
- Trial name
- NCT00408577
- Testing
- L-arginine
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Painful Diabetic Neuropathy
Electromagnetic Stimulation (FREMS) in Patients With Painful Diabetic Neuropathy
We postulate that frequency-modulated electromagnetic stimulation (FREMS) may decrease pain in patients with painful diabetic neuropathy.
- Trial name
- NCT00337324
- Testing
- Frequency-modulated electromagnetic neural stimulation
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease, Type II Diabetes Mellitus
Effect of Metabolic Therapy in Patients With Chronic Ischemic Heart Disease
Patients with coronary artery disease have an abnormal cardiac metabolism. The hypothesis of this study is that shifting cardiac metabolism from free fatty acids to glucose will improve myocardial ischemia
- Trial name
- NCT00282360
- Testing
- Trimetazidine
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele