Clinical trials: sponsored by Institut Pasteur
Lassa Fever
A Trial to Evaluate the Safety, Immunogenicity and the Optimal Dose of MOPEVAC-Las Vaccine Candidate Against Lassa Fever
Lassa fever is an acute viral disease belonging to the category of viral hemorrhagic fevers. It is endemic in West Africa. Outbreaks occur every year, and it is estimated that between 100 000 and 300 000 individuals are infected…
- Trial name
- FIRST-IN-MOP (NCT07833436)
- Testing
- Low dose MOPEVAC-Las vaccine, Intermediate dose MOPEVAC-Las vaccine, High dose MOPEVAC-Las vaccine
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Dengue, Sepsis
Immune Responses to Dengue and Sepsis
The goal of this research study is to help the investigators better understand serious dengue disease. The investigators will collect clinical information and up to four blood samples from participants with dengue, influenza…
- Conditions
- Dengue, Sepsis, Influenza
- Trial name
- DEN-SEP (NCT07040202)
- Where
- 4 sites in Cambodia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Measles
Clinical Diagnostic Performance Evaluation of a Measles Rapid Test in Senegal
The goal of this study is to measure the accuracy of a new measles rapid test when used in clinical health centres in several regions of Senegal.
- Trial name
- NCT05860920
- Testing
- Measles rapid diagnostic test
- Where
- 6 sites in Senegal
- Volunteers
- 254 people
- Sponsor
- Institut Pasteur de Dakar
Hearing Disorders and Deafness
Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music.
- Trial name
- SEQUOIA (NCT07740070)
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Congenital Hearing Loss, Bilateral Cochlear Implants
Investigating the Neural Oscillatory Features for Limited Access to Oral Language in Deaf Children With Early Bilateral Cochlear Implantation
Children with severe-to-profound congenital hearing loss often experience significant language development challenges. While cochlear implants (CIs) can restore auditory input, outcomes vary widely, even among those who receive…
- Trial name
- ICO (NCT07739433)
- Volunteers
- 150 people
- Sponsor
- Institut Pasteur
Hearing Impaired (Partially)
Optimization of Perceived Sound Quality for Music Listening in Hearing Aid Users With Hearing Loss.
This study aims to optimize music listening quality for 66 hearing aid users (33 musicians and 33 non-musician music enthusiasts) by developing a dedicated "Music Program" based on individual frequency preference profiles.
- Trial name
- OPTIMMUSIC (NCT07677748)
- Testing
- Musical listening quality preference test
- Volunteers
- 66 people
- Sponsor
- Institut Pasteur
Environmental Enteric Dysfunction
Probiotic For the Improvement of Environmental Enteropathy in Pregnant Women in Senegal
Stunting in young children refers to attenuated linear growth. In the year 2020, 149.2 million children under the age of 5 were stunted, accounting for 22% of stunting globally.
- Trial name
- PROFE-Sen (NCT05501470)
- Testing
- Probiotic, CapScan®
- Where
- Senegal
- Volunteers
- 76 people
- Sponsor
- Institut Pasteur de Dakar
Leptospirosis, Jarisch Herxheimer Reaction
Ex Vivo Study of Leukocyte Responses in the Blood of Patients With Leptospirosis and ex Vivo Testing of a New Host-targeted Therapeutic Strategy to Restore Phagocytosis of Leptospira
Leptospirosis is a neglected zoonosis caused by pathogenic spirochetes of the genus *Leptospira*, occurring mainly in humid tropical and subtropical regions.
- Trial name
- NEUTROLEPTO-NC (NCT07611591)
- Testing
- 24 ml blood sample at H0, 16 ml blood sample at H3
- Volunteers
- 70 people
- Sponsor
- Institut Pasteur
Hearing Loss, Bilateral or Unilateral
Effectiveness of Speech Therapy for Lip-reading in Patients With Hearing Aids: SCED Study
This study aims to investigate whether lip reading rehabilitation improves viseme recognition in individuals with hearing impairments who use hearing aids.
- Trial name
- SCEDuLL (NCT07028658)
- Testing
- Speechreading training
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut Pasteur
Auditory Perception
Sound Perception Study of Hearing-impaired People With Hearing Aids
The aim of the ETERNEL project will be to study the influence of the perception of a single sound timbre on the understanding of a complex sound scene in hearing-impaired people with hearing aids.
- Trial name
- ETERNEL (NCT06691087)
- Testing
- Influence of the parameters of the sound timbre on the perception of a sound, Complex sound scene comprehension test, Complex sound scene comprehension test with hearing aids
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Diabetes Mellitus, Type 2, Obesity
Gut Microbiota, Diet-INDuced Obesity and Type 2 Diabetes in New Caledonia - MIND
In recent years, the global rise in obesity and type 2 diabetes has become a major public health issue. In New Caledonia, 38% of the adult population has a body mass index ≥30.
- Trial name
- MIND (NCT07205913)
- Testing
- 25 ml blood sample, Urine sample, Stools
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Diarrhea, Infantile
Study on the Association Between Vitamin C Deficiency and Diarrhea in Children
Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to region (bacteria, viruses…
- Trial name
- VITAL (NCT05328037)
- Testing
- Blood sample collection
- Where
- 3 sites in Central African Republic, France and 1 more
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Skin Immunity
Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa (SIAP)
Sex hormones are major regulators of skin immunity. Pregnancy represents a unique physiological state of profound hormonal remodeling.
- Trial name
- SIAP (NCT07291193)
- Testing
- Blood sample, skin microbiota and biopsy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Autism Spectrum Disorder
A Rhythmic and Auditory Approach for Children With Autism Spectrum Disorders (ASD)
The aim of this study is to assess the effectiveness of a rhythmic auditory training program in improving language skills in children with Autism Spectrum Disorder (ASD) who have a language acquisition disorder.
- Trial name
- THETABOOST (NCT07303413)
- Testing
- EEG recording, Picture recognition test
- Volunteers
- 24 people
- Sponsor
- Institut Pasteur
Breastmilk Collection
Impact of Breast Milk on the Infectivity and Transmission of Different Viruses "BREASTMILKVIR"
Exclusive breastfeeding during the first six months of life and continued breastfeeding for at least 24 months constitute the optimal feeding method for infants and young children.
- Trial name
- BREASTMILKVIR (NCT06738563)
- Testing
- Collection breast milk
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Yellow Fever Vaccine
VAC-SIP-YF (Vaccination- Safety & Immunogenicity During Pregnancy- Yellow Fever)
The aim of this study is to compare the immunogenicity induced by yellow fever vaccination administered during pregnancy with that induced by vaccination outside pregnancy, and to assess the maternal and fetal tolerance of this…
- Trial name
- VAC-SIP-YF (NCT06694766)
- Testing
- Blood sample collection
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Bites Monkey
Virus Transmission to People Recently Bitten or With a History of Monkey Bites "SIMVIR
Nonhuman primates (NHPs) constitute an important reservoir of infectious agents, some of which have emerged in human populations as deadly pathogens.
- Trial name
- SIMVIR (NCT07097480)
- Testing
- Blood samples collection, Saliva samples collection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut Pasteur
Snake Bites, Antivenins
Evaluation of Anti-venoms Serum in Africa
There is little or no assessment under real-use conditions of the efficacy and the tolerance in the short, medium and long term of the antivenoms currently on the market and used in the treatment of snake bites.
- Conditions
- Snake Bites, Antivenins, Snake Venoms
- Trial name
- ESAA (NCT03326492)
- Testing
- Antivenom serum Inoserp Pan-Africa® injection
- Where
- 13 sites in Cameroon
- Volunteers
- 474 people
- Sponsor
- Institut Pasteur
Simian Foamy Virus Infection (Disorder)
Simian Foamy Virus Transmission to Humans
About three quarters of the viral agents that have emerged recently in humans are considered to originate from other animals. These viruses have often evolved and spread into the human population through various mechanisms after…
- Trial name
- NCT03225794
- Testing
- Simian foamy virus Infection
- Where
- Cameroon
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur