Clinical trials: sponsored by Istinye University
Temporomandibular Disorders (TMD), Functional Limitation
Functionality and Clinical Correlates in TMD
Temporomandibular disorders (TMD) are among the most common causes of orofacial pain and refer to structural and functional impairments related to the masticatory muscles, surrounding soft tissues, and/or the temporomandibular…
- Conditions
- Temporomandibular Disorders (TMD), Functional Limitation, Pain Severity, Neck Disability
- Trial name
- NCT06937502
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istinye University
Dyspnea, Palliative Care
"Turkish Validation of the Respiratory Distress Observation Scale in Palliative Care"
Dyspnea is a subjective experience influenced by physiological, cognitive, behavioral, and sociocultural factors. While self-reported scales are commonly used to assess dyspnea severity, they are unsuitable for patients unable to…
- Conditions
- Dyspnea, Palliative Care, Reliability and Validity
- Trial name
- NCT06922292
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istinye University
Postoperative Pain
Analgesic Strategies After Mastectomy: RIB vs RIB + DPIPB
This retrospective observational study evaluates postoperative pain outcomes in patients undergoing elective mastectomy who received systemic analgesia, rhomboid intercostal block (RIB), or combined rhomboid intercostal block…
- Trial name
- NCT07401602
- Testing
- Analgesic Strategy
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istinye University
Postoperative Hypoxemia
Postoperative SpO₂/FiO₂ Ratio and Analgesic Methods in Laparoscopic Surgery
This prospective observational study aims to evaluate the association between postoperative oxygenation, assessed by the SpO₂/FiO₂ ratio, and body mass index (BMI), STOP-BANG score, and postoperative analgesic methods in patients…
- Trial name
- NCT07401589
- Testing
- Standard of Care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istinye University
Dysfunctional Breathing, Arterial Hypertension
Dysfunctional Breathing, Exercise Capacity, and Balance in Hypertension
This prospective cross-sectional study aims to investigate the relationship between dysfunctional breathing (DB), exercise capacity, and balance in patients with arterial hypertension (HT).
- Conditions
- Dysfunctional Breathing, Arterial Hypertension, Exercise Capacity, Balance
- Trial name
- NCT06916923
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istinye University
Critical Care, Intensive Care, Critical Illness
Validation of the Turkish RDOS Using End-Tidal Carbon Dioxide
Dyspnea is a complex and distressing symptom frequently observed in critically ill patients and is associated with increased morbidity, mortality, and prolonged intensive care unit (ICU) stay.
- Trial name
- NCT07383389
- Volunteers
- 64 people
- Sponsor
- Istinye University
Hematopoietic Stem Cell Transplantation
Physical Fitness of Allogeneic Stem Cell Transplant
Hematopoietic stem cell transplantation is a treatment used to restore blood cell function in diseases of myeloid and lymphoid origin, which can be malignant or non-malignant.
- Trial name
- NCT07049536
- Testing
- Assessment Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Istinye University
Hyperkyphosis
Scapula Position and Range of Motion, Strength and Performance in Thoracic Hyperkyphosis
In the sagittal plane, the average kyphosis angle between the superior endplate of the T1 vertebra and the inferior endplate of the T12 vertebra is approximately 40 degrees.
- Trial name
- NCT07047794
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istinye University
Osteo Arthritis Knee, Movement Disorders
Investigation of the Effect of Movement Mobilization Concept on Sensory, Pain, Muscle Activation in Patients With Knee Osteoarthritis
Individuals with knee osteoarthritis are one of the groups most affected by musculoskeletal disorders and experience pain and mobility limitations that significantly limit their daily living activities.
- Conditions
- Osteo Arthritis Knee, Movement Disorders, Physical Disability, Knee Osteoarthritis
- Trial name
- NCT06527313
- Testing
- Movement Mobilization Concept, Exercise and Tape, Special Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istinye University
Neutrophil-to-Lymphocyte Ratio, Septorhinoplasty
Preoperative Neutrophil-to-Lymphocyte Ratio and Early Postoperative Pain After Septorhinoplasty
This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock.
- Trial name
- NCT07353138
- Testing
- Observational Study
- Volunteers
- 110 people
- Sponsor
- Istinye University
Postoperative Hypoxemia
Preoperative ROX Index for Predicting Early Postoperative Hypoxemia in ENT Surgery
Early postoperative hypoxemia is a frequent complication after elective ear, nose, and throat (ENT) surgery and may adversely affect recovery in the post-anesthesia care unit (PACU).
- Trial name
- NCT07344103
- Testing
- rox ındex
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Hemiplegia, Hemiplegia Due to Stroke
ICF-Based Effects of PNF and Kinesio Taping on Hand Function in Hemiplegic Stroke
This clinical trial aims to compare the effects of kinesio taping and PNF on hemiplegic hand functions. In addition, the effects of these applications on body structure, activity, and participation will be examined.
- Conditions
- Hemiplegia, Hemiplegia Due to Stroke, Hand Functionality, Upper Extremity
- Trial name
- NCT07014696
- Testing
- PNF application Group, KB application Group, PNF+KB application Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istinye University
Perioperative Diaphragmatic Excursion
Diaphragmatic Excursion Changes and Postoperative Oxygenation After Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy and the associated pneumoperitoneum can impair diaphragmatic mechanics and reduce postoperative oxygenation.
- Trial name
- NCT07332728
- Testing
- Standard perioperative care with observational diaphragm ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istinye University
Physical Fatigue
Effects of Upper Extremity Flywheel Exercises on Skills, Muscle Oxygenation, and Fatigue in Adolescent Basketball
This study will investigate the effects of flywheel exercises targeting the upper extremities on athletic performance, muscle oxygenation, physical fatigue, and muscle strength in adolescent basketball players.
- Trial name
- Flywheel (NCT07331012)
- Testing
- Flywheel Exercises, Traditional Resistance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istinye University
Hyperoxia / High FiO₂ Exposure, Uric Acid/Albumin Ratio (UAR)
Association Between Early FiO₂ Exposure and Changes in the Uric Acid/Albumin Ratio in Septic ICU Patients
This prospective, non-interventional study aims to investigate the relationship between early oxygen exposure and oxidative stress in adult intensive care unit (ICU) patients diagnosed with sepsis or septic shock.
- Trial name
- NCT07332637
- Testing
- Oxygen Exposure (Fraction of Inspired Oxygen, FiO₂) - Standard of Care (Observational, No Experimental Intervention)
- Volunteers
- 110 people
- Sponsor
- Istinye University
Sepsis-Related Mortality, Acute Kidney Injury
Predictive Value of the Uric Acid/Albumin Ratio and Lactate in Sepsis Patients
Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection and remains a leading cause of morbidity and mortality in intensive care units.
- Trial name
- NCT07332715
- Testing
- Non-interventional / Observational Study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Obstructive Sleep Apnea Syndrome (OSAS)
The Effect of Inspiratory Muscle Training on Cognitive Functions, Cerebral Oxygenation, and Neurotrophic Factor Level in Patients With Obstructive Sleep Apnea Syndrome
The aim of this clinical study is to examine the effect of an 8-week training program applied to the respiratory muscles that enable breathing in individuals with obstructive sleep apnea syndrome on cognitive functions…
- Trial name
- NCT07329049
- Testing
- inspiratory muscle training, Usual Care
- Volunteers
- 42 people
- Sponsor
- Istinye University
Hypoxemia
Preoperative ROX Index and Postoperative Hypoxemia in Bariatric Surgery
This prospective observational study evaluates whether the preoperative ROX index can predict early postoperative hypoxemia in patients undergoing bariatric surgery.
- Trial name
- NCT07303205
- Testing
- Preoperative ROX Index Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Awareness of Surgeon, Preoperative Evaluation
Awareness of Surgeons
It aims to objectively reveal the current knowledge levels of surgical physicians, to increase their awareness, and to contribute to in-house training processes with the results obtained and to fill an important gap in the…
- Trial name
- NCT07282730
- Testing
- Surgeons' knowledge levels regarding preoperative evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istinye University
Interstitial Lung Disease
The Effect of Video Game-Based Exercise Training in Patients With Interstitial Lung Disease
The goal of this prospective randomized controlled clinical trial is to evaluate the effects of video game-based physiotherapy and rehabilitation on functional exercise capacity and respiratory parameters in individuals with…
- Trial name
- NCT07167238
- Testing
- Virtual reality exercises, Home exercises
- Volunteers
- 42 people
- Sponsor
- Istinye University