Clinical trials: sponsored by Istituto Ortopedico Rizzoli
Deformity of Bone
Archive of Custom-made Guides for Orthopedic Surgery
The present study aims to design, develop and test an electronic archive to be able to track over time the so-called Patient-Specific Cutting Guides for Orthopedics (in English often known as ' Pa-tient-Specific Cutting Guides').
- Trial name
- NCT07893132
- Testing
- Archive
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Ortopedico Rizzoli
Lymphedema
Use of Reconstructive Microsurgery for the Treatment of Lymphedema
Lymphedema is a chronic condition characterized by the accumulation of lymphatic fluid in tissues, frequently resulting from oncological treatments, trauma, or cancer.
- Trial name
- NCT07889856
- Testing
- Surgery with and without the aid of Indocyanine Green (ICG)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Arthritis
Transarterial Embolization Versus Sham Procedure in Adults With Treatment-Resistant Inflammatory Arthritis of a Single Large Joint
The goal of this clinical trial is to learn whether transarterial embolization (TAE) can relieve pain and improve well-being in adults with inflammatory arthritis that remains active in only one large joint (wrist, elbow…
- Trial name
- ADVENTURE (NCT07873892)
- Testing
- Transarterial embolization with resorbable gelatin microspheres
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Flat Foot
The Corrective Power of Subtalar Arthrodesis With Mini/Medial Bone Block (SAMBB) in Patients Affected by Progressive Collapsing Foot Deformity (PCFD): Analysis Using Weight-bearing Cone Beam CT.
Progressive Collapsing Foot Deformity (PCFD) is a complex, multiplanar condition characterized by hindfoot valgus, peritalar subluxation, midfoot abduction, and collapse of the medial arch, which may progress to rigid deformity…
- Trial name
- NCT07515170
- Testing
- Weight-Bearing CT scan
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Spine Disease, Urologic Diseases
Active Informed Consent: a New Solution to Improve and Objectively Test the Patient Understanding of Complex Surgical Procedures Proposals
This is an interventional, non-pharmacological, randomized controlled superiority study (RCT), multicenter, open label, parallel group.
- Trial name
- NCT06059599
- Testing
- active informed consent
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Ortopedico Rizzoli
Meniscus Disorder, Arthritis Knee
Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation (MAT) at 10 Years.
Menisci are crescent-shaped cartilage structures that are fundamentally important for the biomechanics and physiology of the knee joint.
- Trial name
- MAT 10 Y (NCT06522152)
- Where
- Italy
- Volunteers
- 397 people
- Sponsor
- Istituto Ortopedico Rizzoli
Multiple Osteochondroma, Enchondromatosis
Survey on Multiple Osteochondromas and Enchondromatoses During the Transition From Paediatric Care to Adult Care
This prospective observational study aims to understand the transition experiences and unmet needs of patients living with multiple osteochondromas or enchondromatoses during the paediatric to adult care, in order to produce a…
- Trial name
- PJMOE (NCT07839637)
- Where
- Italy
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Sarcoma, Ewing
Identification of Circulating Biomarkers Associated With Extracellular Vesicles in Sarcomas
The study involves blood samples from patients with Ewing's sarcoma to identify circulating biomarkers as a tool for the preclinical validation of innovative therapeutic approaches
- Trial name
- BIOVES (NCT07685405)
- Testing
- one blood sample, 3 blood samples
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis, Knee, Cartilage Degeneration
Analysis of the Pathophysiological and Functional State of the Knee Joint
Osteoarthritis is the most common degenerative condition affecting the knee joint globally, with an incidence of about 7% of the population.
- Trial name
- Gait-MRI-Knee (NCT06490770)
- Testing
- Gait analysis, Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Ortopedico Rizzoli
Tendon Rupture
Evaluation of Clinical Results of Patients Treated Conservatively for Distal Biceps Tendon Lesions
A clinical evaluation of the results of conservative treatment after distal biceps tendon rupture with a minimum follow up of 1 year.
- Trial name
- CoB (NCT06602414)
- Testing
- Conservative treatment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cartilage Injury, Cartilage Disease
Long-term Outcome Evaluation of Patients Undergoing Autologous Chondrocyte Transplantation Delivered on Biomaterial
Chondro-Long study is prospective observational study for a long-term clinical evaluation (follow-up up to 25 years) in patients treated with autologous chondrocyte transplantation delivered on biomaterial for full-thickness…
- Trial name
- NCT06238947
- Volunteers
- 200 people
- Sponsor
- Istituto Ortopedico Rizzoli
FemoroAcetabular Impingement
Arthroscopic Treatment of Acetabular Labral Lesions: Intrarticular Injection of Bone Marrow vs Hip Arthroscopy Alone
The BoneMarrowHip study is a single-blind, randomized, single-center trial. Through this study, the clinical results of patients treated during hip arthroscopy surgery with autologous bone marrow infiltration taken from the…
- Trial name
- NCT07422662
- Testing
- Hip arthroscopy + BMAC injection, Hip arthroscopy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Ortopedico Rizzoli
Prosthesis Survival, Arthropathy of Knee
Evaluation of 5-year Survival and Clinical Outcomes in Patients Undergoing Total Knee Arthroplasty With a Polyethylene Tibial Component
Total knee arthroplasty (TKA) is one of the most successful procedures in orthopedic surgery for treating advanced knee osteoarthritis, providing pain relief, functional recovery, and improved quality of life.
- Trial name
- ALLPOLY-TKA (NCT07544264)
- Testing
- Total knee arthroplasty
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Istituto Ortopedico Rizzoli
Aseptic Loosening, Arthropathy of Knee
Economic-demographic Assessment of the Aseptic Mobilization of Knee Prostheses Through the RIPO Registry and Radiographic Analysis of the Case Series From the II Clinic of IOR
The increase in life expectancy is leading to an increase in the average age of patients undergoing total knee arthroplasty (TKA), and, consequently, an increase in the number of revisions.
- Trial name
- AL-TKA (NCT06821581)
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Istituto Ortopedico Rizzoli
Artificial Intelligence (AI), Machine Learning
Development and Pre-validation of a Machine Learning-based Prediction Algorithm for Early Functional Recovery in Patients Undergoing Hip and Knee Replacement Surgery
The goal of this observational study is to develop and pre-validate a machine learning algorithm to predict early recovery of mobility in patients undergoing hip or knee joint replacement surgery.
- Conditions
- Artificial Intelligence (AI), Machine Learning, Joint Replacement, Predictive Model
- Trial name
- FISIO_IA (NCT07333560)
- Testing
- Predictive Model for Early Mobility Recovery and Length of Stay
- Where
- 2 sites in Italy
- Volunteers
- 943 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoporosis, Osteopenia
Peripheral Mononuclear Cells to Screen, Monitor and Stratify the Population at Risk of Osteoporosis and Fractures
Osteoporosis (OP) is one of most common age-associated and chronic metabolic bone diseases, featured by a decrease of bone mineral density (BMD) that increases the risk of bone fractures.OP guidelines agree that Dual-X-ray…
- Conditions
- Osteoporosis, Osteopenia, Osteoporosis Fracture
- Trial name
- DISCERN (NCT06551155)
- Testing
- Vitality and biological activity of peripheral blood mononuclear cells (PBMCs)
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Ortopedico Rizzoli
Degenerative Spine Diseases
Vertebral Bone Marrow Clot for Spinal Surgery
Spinal fusion (SF) is a common orthopedic procedure to treat spinal diseases. Apart from fixation systems, the procedure requires bone grafting to further improve SF.
- Trial name
- NCT05947175
- Testing
- Vertebral bone marrow (vBMA) clot, Bone allograft chips
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Istituto Ortopedico Rizzoli
Hemophilia, Sports Physical Therapy
Effectiveness of an Adapted Physical Activity Program for Subjects Suffering From Haemophilia
The present study aims to evaluate the modification of functional capacity induced by an adapted physical activity program in subjects with haemophilia.
- Trial name
- EMO-AFA (NCT06580340)
- Testing
- AFA (Adapted Physical Activity)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Istituto Ortopedico Rizzoli
Total Hip Arthroplasty (THA)
Observational Study on AI Accuracy in Diagnosing and Treating Failed or Painful Hip Arthroplasty
Primary Goal: This study aims to evaluate the diagnostic and therapeutic accuracy of GPT-4 (an advanced AI language model) compared to three orthopedic surgeons with varying experience levels in cases of failed or painful total…
- Trial name
- PAINGPT (NCT07012577)
- Testing
- GPT-4 Assessment, Arthroplasty Fellow Assessment, Specializing Resident (4th year) Assessment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Approach-Approach Conflict, Knee Discomfort
Compliance With PROMs Detection Through Digital Support and Correlation Compared Standard to Outpatient Detection in Knee Prosthetics
Two methods for detecting outcomes after knee prosthetic surgery are compared: the traditional one using paper questionnaires administered in the outpatient setting (Oxford Knee Score) VS detection using digital questionnaires…
- Trial name
- DIG-PROMs-k (NCT04752761)
- Testing
- Extrambulatory digital PROMs detection
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli