Clinical trials: sponsored by Kafrelsheikh University
Ectopic Pregnancy
Letrozole Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy
The aim of work is to study the effectiveness of letrozole in treatment of early undisturbed ectopic pregnancy in comparison with Methotrexate.
- Trial name
- NCT07624903
- Testing
- Methotrexate (drug), Letrozole 2.5Mg Tab
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Kafrelsheikh University
Heart Failure, Heart Valve Prosthesis
Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves
This study evaluates whether adding a medication called semaglutide to an existing treatment of dapagliflozin provides better outcomes for patients with heart failure who have previously undergone surgical heart valve…
- Trial name
- SYNCARDIA-HF (NCT07610174)
- Testing
- semaglutide, Dapagliflozin (10mg Tab)
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Kafrelsheikh University
CRSWNP
Th Study Wants to Compare the Best Technique for Sinus Operation in CRSWNP
This randomized controlled trial aims to compare the efficacy and safety of reboot surgery versus conventional full house FESS in patients with refractory CRSwNP, focusing on: 1.
- Trial name
- REBOOT (NCT07368361)
- Testing
- endoscopic nasal operation, Reboot operation" Complete removal of inflamed mucosa to periosteum"
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
CSF Leak
Evaluation of Internal Nasal Splint-Supported Free Graft Versus Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks
The study aims to compare the feasibility and effectiveness of using an internal nasal splint- supported free graft versus a nasoseptal flap alone for endoscopic repair of bilateral CSF leaks.
- Trial name
- CSF (NCT07368348)
- Testing
- Internal Nasal Splint-Supported Free Graft, Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kafrelsheikh University
Migraine
Zonisamide Versus Topiramate in Migraine
Investigators aim to compare the effect of zonisamide versus topiramate in migraine by assessing the absolute reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days…
- Trial name
- NCT06347497
- Testing
- Zonisamide 50 MG, Topiramate 50 MG
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Kafrelsheikh University
Synechia After DCR
Endoscopic DCR With and Without Internal Nasal Splint
This study aims to compare the outcomes of endoscopic DCR performed with versus without internal nasal splints, by assessing functional outcomes, complication rates, and overall success rates.
- Trial name
- NCT07605026
- Testing
- Endoscopic DCR with putting internal nasal splint, Endoscopic DCR without putting internal nasal splint
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Kafrelsheikh University
Laparoscopic Hysterectomy
Total Laparoscopic Hysterectomy With Prior Uterine Artery Cauterization From the Origin Versus Conventional Laparoscopic Hysterectomy
The main goal of this study is to compare between total Laparoscopic hysterectomy proceeded by Uterine artery cauterization at its origin and conventional total Laparoscopic hysterectomy regarding: bleeding , operative time …
- Trial name
- NCT07601971
- Testing
- Total Laparoscopic hysterectomy with prior Uterine artery cauterization from the origin to arm 1, Conventional Laparoscopic hysterectomy to arm 2, Total Laparoscopic hysterectomy with conventional uterine artery ligation
- Volunteers
- 44 people
- Sponsor
- Kafrelsheikh University
Varicose Veins of Lower Limb, Great Saphenous Vein (GSV) With Venous Reflux Disease
Endovenous Laser Ablation With 1940 nm Versus 1470 nm
1. Study Design: A single-blind, prospective, randomized controlled trial (RCT) conducted at Kafrelsheikh University Hospital to compare the efficacy and safety of 1940 nm vs. 1470 nm diode lasers for EVLA. 2.
- Trial name
- EVLA (NCT07603570)
- Testing
- EVLA for SFJ with laser 1470, EVLA for SFJ with laser 1940
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Kafrelsheikh University
Intractable Allergic Rhinitis
Posterior Nasal Nerve Neurectomy for Treatment of Intractable Allergic Rhinitis
This study aims to compare the outcomes of posterior nasal nerve neurectomy in patients with resistant Allergic rhinitis by using three different methods ( surgical resection vs radiofrequency ablation vs surface coblation )…
- Trial name
- NCT06887842
- Testing
- Posterior Nasal Nerve neurectomy
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Kafrelsheikh University
Dental Implant Failed
Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics
The present study aims to evaluate and compare the clinical, radiographic, and biological peri-implant tissue outcomes of platelet-rich fibrin versus probiotics as adjuncts to immediate implant placement combined with…
- Trial name
- NCT07596758
- Testing
- Platelet-Rich Fibrin, Probiotics
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Chronic Tonsillitis
Coblation Tonsillotomy Versus Radiofrequency and Cold Knife Dissection Tonsillectomy
This study aims to assess and compare the outcomes between coblation intracapsular tonsillotomy versus extracapsular Radiofrequency and cold knife dissection tonsillectomy efficacy in managing patients requiring tonsil surgery as…
- Trial name
- NCT06937762
- Testing
- Intra capsular coblation tonsillotomy, Extracapsular cold knife dissection tonsillectomy, Extra capsular Radiofrequency tonsillectomy
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Kafrelsheikh University
Subthreshold Diode Laser, Trabeculotomy
Subthreshold Diode Laser Versus Trabeculotomy in Treatment of Advanced Primary Open Angle Glaucoma
This study aimed to compare between subthreshold diode laser and trabeculotomy in treatment of advanced primary open angle glaucoma throughout 12 months follow-up.
- Conditions
- Subthreshold Diode Laser, Trabeculotomy, Advanced Primary Open Angle Glaucoma, Intraocular Pressure
- Trial name
- NCT07591662
- Testing
- Subthreshold diode laser, Trabeculotomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Dental Implant Failed
Guided Modified Socket Shield With Hyaluronic Acid for Black Triangle Management
The Primary aim of this study will be to evaluate the clinical, esthetic, and radiographic outcomes of hyaluronic acid combined with immediate implant placement using AI-assisted and computer guided modified socket shield…
- Trial name
- NCT07586228
- Testing
- Guided socket shield without Hyaluronic acid, Guided socket shield with hyaluronic acid
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Implant Complication, Dental Implant Failed
Artificial Intelligence Assisted Socket Shield With Computer Guided Implant Placement
Aim of the current randomized clinical trial is to evaluate and compare the effectiveness of computer-guided immediate implant placement performed simultaneously with artificial intelligence assisted socket shield technique…
- Trial name
- NCT06299449
- Testing
- free-hand socket shield, AI/guided socket shield
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
PLEURA DISEASE
Ultrasound Guided Erectror Spinae Block Versus Intracavitary During Medical Thoracoscopy
The primary aim: is to compare the effect of US guided ESP block at two levels versus intracavitary blockade in medical thoracoscopy on total peri-procedural (intraoperative and post-operative 12 hours) nalbuphine consumption…
- Trial name
- ESPB (NCT07572019)
- Testing
- ultrasound-guided erector spinae plane block in medical pleuroscopy, Intracavitary anaesthesia ICA
- Volunteers
- 100 people
- Sponsor
- Kafrelsheikh University
Liver Cirrhosis, Portal Vein Thrombosis
Clinical Application of Simcyp-Guided Warfarin Initiation Doses in Cirrhotic Patients With Portal Vein Thrombosis
This was a prospective, open-label, pilot interventional clinical study conducted on Egyptian patients with liver cirrhosis complicated by portal vein thrombosis (PVT) who were indicated for anticoagulation therapy.
- Trial name
- NCT07571460
- Testing
- Warfarin 3 mg, Warfarin 2 mg
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Kafrelsheikh University
Sensori-Neural Deafness, Exosomes
A Randomized Trial of Intratympanic Drug Delivery: Evaluating the Efficacy and Safety of Dexamethasone-Loaded Exosomes Versus Standard Therapy in Acute Sensorineural Hearing Loss.
Primary Objective To compare the efficacy of a single course of IT Exo-Dex versus conventional IT dexamethasone and exosome vehicle alone, as measured by the mean change in pure-tone average (PTA; 0.5, 1, 2, 4 kHz) from baseline…
- Trial name
- EXO-DEX-SNHL (NCT07568184)
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Erectile Dysfunction, Left Ventricular Diastolic Dysfunction
Association Between Diastolic Dysfunction and Erectile Dysfunction and the Effect of Tadalafil and SGLT2 Inhibitors on Them in Men With Metabolic Syndrome
Metabolic syndrome is associated with an increased risk of cardiovascular disease and is commonly accompanied by erectile dysfunction and subclinical cardiac dysfunction.
- Conditions
- Erectile Dysfunction, Left Ventricular Diastolic Dysfunction, Metabolic Syndrome
- Trial name
- METDDED (NCT07563647)
- Testing
- Tadalafil 5 mg, SGLT-2 inhibitor, Tadalafil plus SGLT2 inhibitors
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Single Layer, Unlocked Sutures
Single Layer With Unlocked Sutures Versus Double Layer Closure of Cesarean Incision and the Risk of Niche Development
This study aimed to compare the development of the uterine niche after single and double closure of cesarean incision.
- Conditions
- Single Layer, Unlocked Sutures, Double Layer Closure, Cesarean Incision
- Trial name
- NCT07554001
- Testing
- Single layer unlocked sutures, Double layer unlocked sutures
- Where
- Egypt
- Volunteers
- 366 people
- Sponsor
- Kafrelsheikh University
Ischemic Stroke
Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Small Vessel Stroke
Along with the current clinical trial, the impact of adding atorvastatin or rosuvastatin in the first 24 hours on the clinical outcomes of first-ever small vessel stroke patients treated with clopidogrel and aspirin assessed…
- Trial name
- NCT06358313
- Testing
- Atorvastatin 40mg, Rosuvastatin 20mg
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Kafrelsheikh University