Clinical trials: sponsored by Laval University
Psychosocial Impacts of the COVID-19 Pandemic
MAVIPAN: My Life and the COVID-19 Pandemic
The health crisis imposed by COVID-19 is forcing major worldwide social reorganization that will have profound consequences on our society.
- Trial name
- NCT04575571
- Testing
- No intervention, this is an observational study that uses validated questionnaires and qualitative interviews..
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity
The Addition of Probiotic Consumption to a Nutritional Intervention and Caloric Restriction on Body Weight and Composition in Overweight Participants
Limited interventional human studies suggest that probiotic supplementation may be a beneficial strategy for promoting weight loss when added to a nutritional intervention via their effects on lipid absorption and metabolic…
- Trial name
- NCT02962583
- Testing
- Weight loss, Probiotic Formula
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Laval University
Pulmonary Arterial Hypertension
Olaparib for PAH: a Pilot Study
The main OBJECTIVE of this proposal is to extend our preclinical findings on the role of DNA damage and poly(ADP-ribose) polymerases (PARP) inhibition as a therapy for a devastating disease, pulmonary arterial hypertension (PAH)…
- Trial name
- OPTION-p (NCT03251872)
- Testing
- Olaparib
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Laval University
Food Habits, Self Efficacy
Edible Seaweeds and Health: Quality Biomarkers to Support Consumer Acceptance
Seaweeds have been part of the diet of Asian countries for thousands of years, but consumption by Quebecers remains unfamiliar. Because of their rich nutrients content and unique bioactive compounds, seaweeds have a great dietary…
- Trial name
- (CuisiAlg) (NCT04493944)
- Testing
- Culinary workshop
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Laval University
Lung Collapse, One-Lung Ventilation
Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Lung isolation technique and one-lung ventilation (OLV) are the mainstays of thoracic anesthesia. Two principal lung isolation techniques are mainly use by clinicians, the double lumen tubes (DLT) and the bronchial blockers (BB).
- Conditions
- Lung Collapse, One-Lung Ventilation, Thoracic Surgery, Video-Assisted
- Trial name
- PLC-OLV (NCT02919267)
- Testing
- Double lumen tube, Bronchial blocker
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laval University
Type 2 Diabetes Mellitus
Sitagliptin Therapy and Kinetics of Inflammatory Markers
Inflammatory processes are increasingly being recognized as a critical step in the pathogenesis of both diabetes and heart disease and may constitute a biological link between the two diseases.
- Trial name
- NCT02536248
- Testing
- Sitagliptin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Coronavirus, Pneumonia
Closed-Loop Oxygen to Verify That Healthcare Workers Interventions Decrease During SARS-CoV-2 Pneumonia (COVID-19)
There is a high risk of transmission of COVID-19 to healthcare workers. In a recent cohort, 29% of the patients hospitalized were healthcare workers.
- Conditions
- Coronavirus, Pneumonia, Oxygen Toxicity
- Trial name
- NCT04320056
- Testing
- Standard administration of oxygen flow, Automated oxygen administration - FreeO2
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Laval University
Thoracic CT-scan, Right Upper Lobe Anatomy
New Measures for Tracheobronchial Anatomy
The right-sided double lumen endobronchial tube (R-DLT) is seldom. The principal cause of reticence for using the R-DLT are the difficult positioning of its lateral orifice in front of the origin of the right upper lobe (RUL) and…
- Conditions
- Thoracic CT-scan, Right Upper Lobe Anatomy, Right Sided Double Lumen Endobronchial Tube
- Trial name
- ATB (NCT02366455)
- Testing
- Measurement of the length of the right main stem bronchus, Measurement of the right upper lobe bronchus antero-posterior angulation
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight, Insulin Resistance
Effects of Cranberry Powder Supplements on Gut Microbiota Diversity and Metabolic Syndrome
It is of major importance to refine prevention strategies in order to alleviate inflammation, insulin resistance and metabolic syndrome and it appear that improving gut health and microbiota represent a promising strategy.
- Conditions
- Overweight, Insulin Resistance, Microbiota, Endotoxemia
- Trial name
- MICA (NCT03754504)
- Testing
- Cranberry powder
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity, Morbid
EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
The risk of complication associated with airway in obese patient is important. The result of pre-oxygenation gives the clinician a prolonged non-hypoxic apnea time.
- Trial name
- EPO2-A (NCT02590406)
- Testing
- Beach chair (BC) and ZEEP, Reverse Trendelenburg and NIPPV
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Depression
Depression Medication Choice Decision Aid
The quality of care for patients facing depression, one of the most prevalent chronic diseases, needs improvement. Despite its high incidence, depression remains sub-optimally managed, particularly in primary care, where most…
- Trial name
- NCT03887390
- Testing
- Depression Medication Choice
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Laval University
Human Papillomavirus
Immunogenicity of Gardasil and Twinrix and the Effect of a Dose of Gardasil or Cervarix Given 42 Months Later.
Two human papillomavirus vaccines are now commercially available. No clinical data exist regarding: The immunogenicity and safety of Gardasil and Twinrix when co-administered.
- Trial name
- NCT01456715
- Testing
- Gardasil vaccine, Immunogenicity, Booster dose., Cervarix Vaccine, Immunogenicity, Booster Dose.
- Where
- Canada
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Laval University
HPV Infection
HPV Prevalence in 16-20 Year Old Males
In Quebec, 18 birth cohorts of girls were vaccinated against HPV (aged 9 to 29 years in 2020). With an observed vaccination coverage of >80% an important herd effect might be expected.
- Trial name
- NCT04297670
- Testing
- Measurement of HPV types prevalence
- Where
- Canada
- Volunteers
- 681 people, healthy volunteers welcome
- Sponsor
- Laval University
Food Habits
Investigation of Microbiome-Derived Metabolite Production in Response to a Mediterranean Diet
This project proposes to characterise the microbiome-derived metabolites produced upon ingestion of bioactive precursor-rich meals by healthy volunteers in order to investigate the relationship between gut microbiome composition…
- Trial name
- META (NCT03783260)
- Testing
- Mediterranean diet
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Laval University
Food Habits, Energy Metabolism
Environmental Factors and the Gut Microbiome - Endocannabinoid Axis
The general objective of this project is to investigate the interplay of the gut microbiome - endocannabinoid axis with host environmental factors and intestinal, metabolic and mental health status in free-living adults with…
- Conditions
- Food Habits, Energy Metabolism, Mental Health Wellness 1, Intestinal Disease
- Trial name
- eMECA (NCT03463304)
- Where
- Canada
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Laval University
Heterozygous Familial Hypercholesterolemia
Lp(a) and Aortic Valve Calcification
Aortic valve stenosis (AVS), the most common form of valve disease in the western world, afflicts more than 1 million individuals in North America [1] and the burden of AVS is high and is expected to double within the next 50…
- Trial name
- FHLPA (NCT02976818)
- Where
- Canada
- Volunteers
- 173 people
- Sponsor
- Laval University
Full-thickness Rotator Cuff Tear
Why Does my Shoulder Hurt? Understanding the Presence of Pain in Individuals With Full-thickness Rotator Cuff Tears
Full-thickness rotator cuff tears (FTRCT), defined as "through-and-through" tears of one of the shoulder tendons, affect up to 32% of the population (mostly individuals older than 50 years) and are one of the most painful and…
- Trial name
- NCT03857009
- Where
- Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Laval University
Pulmonary Arterial Hypertension, Exercise Training
Home-based Exercise Training in Patients With Pulmonary Arterial Hypertension: Effect on Skeletal Muscular Function and Metabolism
Pulmonary Arterial Hypertension has gone from a disease that causes rapid death to a more chronic condition. Yet, improved survival is associated with major challenges for clinicians as most patients remain with poor quality of…
- Conditions
- Pulmonary Arterial Hypertension, Exercise Training, Home-based Rehabilitation, Exercise Capacity
- Trial name
- NCT04241497
- Testing
- Home-based rehabilitation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Laval University
Pulmonary Disease, Chronic Obstructive
The Effect of Respiratory Training on Exercise Tolerance in COPD
Exercise intolerance is one of the key disabling factors in patients with chronic obstructive pulmonary disease (COPD). Although multifactorial, exercise intolerance involves physiological interactions between respiratory and…
- Trial name
- ERTET (NCT04201522)
- Testing
- Normocapnic hyperpnoea intervention
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Obesity
Transradial Selective Catheterization of the Celiac Artery in Obese Patients
BACKGROUND: Obesity, with its associated comorbidities, is set to become a major risk factor for cardiovascular disease in the 21st century.
- Trial name
- NCT03434665
- Testing
- Transradial celiac artery angiography
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Laval University