Clinical trials: open to volunteers, sponsored by Laval University
Oxygen Toxicity, COPD Bronchitis
Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates
Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently…
- Conditions
- Oxygen Toxicity, COPD Bronchitis, Respiratory Failure
- Trial name
- Interfaces (NCT06646991)
- Testing
- Nasal canula - up to 6 liters per minute, Nasal canula - up to 15 liters per minute, Open oxygen mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Mechanical Ventilator Care
Measurement of Expiratory Gas Temperature in Intubated Patients to Estimate Expiratory Absolute Humidity
Adequate humidification is essential for intubated patients because dry medical gases can cause thick secretions and dangerous endotracheal tube blockages.
- Trial name
- NCT07420673
- Testing
- Expiratory gases temperature
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Laval University
Respiratory Failure, Hypoxemia
Comparison of Pulse Oximetry (SpO2) With Different Oximeters and Arterial Saturation (SaO2): Oxygap2 Study
The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and…
- Conditions
- Respiratory Failure, Hypoxemia, Hyperoxemia
- Trial name
- Oxygap 2 (NCT06102499)
- Testing
- SpO2 and SaO2 comparison
- Where
- 5 sites in Canada, Guadeloupe and 1 more
- Volunteers
- 250 people
- Sponsor
- Laval University
Thoracic, Surgery
Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application
One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce…
- Conditions
- Thoracic, Surgery, Mechanical Ventilation, Hypercapnia
- Trial name
- NCT07099963
- Testing
- one lung ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction
Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery
Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by…
- Conditions
- Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction, Hemodynamic Changes, Mechanical Ventilation
- Trial name
- NCT07619274
- Testing
- Not applicable- observational study
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Laval University
Cardiac Arrest (CA), Cardiogenic Shock
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock.
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation, Acid Base Disorder
- Trial name
- VentilO CU (NCT07484828)
- Testing
- Initiation of mechanical ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Oxygen Toxicity, Respiratory Failure
Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and Oxygenation
The investigators recently evaluated 4 different oximeters among the most commonly used with arterial catheter in place and compared SpO2 with SaO2 obtained on arterial gas.
- Trial name
- Oxygap pong (NCT05590130)
- Testing
- Manual Oxygen titration with Philips oximeter (SpO2 target 90%), Manual oxygen titration with Nonin oximeter (SpO2 target 90%), Manual Oxygen titration with Philips oximeter (SpO2 target 94%)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Cardiovascular (CV) Risk, Metabolic Health
Advancing Health Equity and Preventive Cardiovascular Care in Indigenous and Remote Communities: a Mobile Healthcare Unit
Indigenous people living in Canada face significant healthcare inequities, particularly in basic, primary, and secondary prevention, leading to higher rates of cardiovascular disease and mortality.
- Conditions
- Cardiovascular (CV) Risk, Metabolic Health, Primary Prevention
- Trial name
- NCT07869069
- Testing
- Cardiovascular risk screening, Follow-up of cardiovascular risk factors
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Laval University
Digital Health Intervention, Remote Consultation, Teleconsultation
Evaluation and Implementation of Digital Health Ecosystem in Academic Health Center
Mobile health technologies, such as smartwatches, wearable sensors, and digital applications, have the potential to support healthier lifestyles and improve the management of health conditions.
- Conditions
- Digital Health Intervention, Remote Consultation, Teleconsultation, Lifestyle Factors, Stress
- Trial name
- e-IDEA (NCT07831837)
- Testing
- Integrated Digital Health Ecosystem, Usual Primary Care
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Chronic Pain, Kinesiophobia (Fear of Movement)
Virtual Reality for Pain and Well-Being in Older Adults
Chronic pain is common among adults aged 65 and older and can reduce mobility, independence, mood, and quality of life. Many older adults also develop a fear of movement because they worry that physical activity will increase…
- Trial name
- VitaMove (NCT07607899)
- Testing
- Virtual Reality-Supported Rehabilitation, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Laval University
Cognitive Impairment, Long-term Care Centres for Old Adults Users
Immersive Virtual Reality for Older Adults in Long-Term Care Settings
The goal of this clinical trial is to learn if an immersive virtual reality mindfulness meditation program is feasible and acceptable for older adults living in long-term care settings in Quebec who have mild to moderate…
- Trial name
- VR-LTC (NCT07658287)
- Testing
- Adapted Virtual Reality Mindfulness Meditation Program, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Laval University
Obesity, Morbid
Investigating Metabolic, Brain, and Cognitive Alterations Through Bariatric Surgery
Despite global efforts, the prevalence of obesity continues to rise, with rates in Canada tripling over the past three decades. In addition to the well-established risk of cardiometabolic conditions such as heart disease and…
- Trial name
- BRAINS (NCT07704229)
- Testing
- Sleeve Gastrectomy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Laval University
Obesity & Overweight, Cardiometabolic Conditions
Incretin-based Therapies, Nutrition, and Physical Activity
The goal of this clinical trial is to evaluate whether combining a six-month structured lifestyle intervention (physical activity and nutrition) with incretin-based weight-loss medication improves preservation of muscle mass and…
- Trial name
- HARMONY (NCT07409831)
- Testing
- Intervention, Incretin-Based Treatment
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Laval University
Peripheral Artery Disease
Home-based Exercise Therapy in Patients With Moderate to Severe Peripheral Artery Disease
Peripheral arterial disease (PAD) is a chronic atherosclerotic condition associated with impaired mobility, reduced quality of life, cardiovascular events, and risk of lower limb amputation.
- Trial name
- PILOT-PADCYCLE (NCT07655206)
- Testing
- Home-Based Exercise Therapy Using Portable Pedal Exerciser
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Laval University
Insomnia Disorder
Virtual Reality Relaxation for Insomnia
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effects of a virtual reality (VR) relaxation intervention among adults aged 25 to 50 with insomnia disorder.
- Trial name
- NCT07630532
- Testing
- Virtual reality relaxation intervention
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Body Composition Changes, Body Weight Change
Effect of Dairy Protein Yogourt vs Plant-based Yogourt on Body Weight, Body Composition, Bone Health and Gut Microbiota
The consumption of an adequate quantity of protein in the diet is essential to maintain a healthy body composition and functioning.
- Conditions
- Body Composition Changes, Body Weight Change, Metabolic Health, Bone Metabolism
- Trial name
- PROYO (NCT07578103)
- Testing
- Dairy yogurt, Plant based yogurt, No yogurt
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Laval University
Non-specific Low Back Pain
Effectiveness of Motorised Lumbar Support for Non-specific Low Back Pain
Low back pain (LBP) represents a common musculoskeletal conditions worlwide, causing substantial disability and economic burden.
- Trial name
- NCT07366827
- Testing
- Motorized lumbar support, Standard lumbar support
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Laval University
Overweight/Obesity, Metabolic Syndrome
Effects of Cranberry on Gut and Metabolic Health
The consumption of plant-based foods, particularly berries, has been associated with improved health due to their high content of bioactive compounds.
- Conditions
- Overweight/Obesity, Metabolic Syndrome, Insulin Resistance, Microbiota
- Trial name
- CRANOS (NCT07460856)
- Testing
- Cranberry beverage
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University
Oxygen Delivery, Acute Respiratory Failure
Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy
Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target.
- Conditions
- Oxygen Delivery, Acute Respiratory Failure, High Flow Oxygen Therapy, Hypoxemic Acute Respiratory Failure
- Trial name
- NCT07168213
- Testing
- Manual FiO2 titration with Philips oximeter (SpO2 target 90%), Manual FiO2 titration with Nonin oximeter (SpO2 target 90%), Manual FiO2 titration with Philips oximeter (SpO2 target 94%)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay, Spastic Paraplegia 7
Effects of a Supervised Rehabilitation Program on Disease Severity in Spastic Ataxias
Spastic ataxias are a group of diseases causing symptoms such as walking difficulties and balance impairments that lead to a high risk of falls. No pharmacological treatments exist to treat these diseases.
- Trial name
- NCT06261424
- Testing
- IMPACT - rehabIlitation prograM for sPAstiC aTaxias
- Where
- 5 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Laval University