Clinical trials: sponsored by Leiden University Medical Center
Self-Injurious Behavior
The (Cost-) Effectiveness of Mindfulness-training and Cognitive Behavioural Therapy in Adolescents and Young Adults With Deliberate Self Harm
Background: In recent years, there has been a marked rise in the frequency of young people engaging in Deliberate Self-Harm (DSH). DSH refers to all kinds of self-harming behaviour, with and without suicidal intent.
- Trial name
- DSH (NCT00694668)
- Testing
- Cognitive Behavioral treatment, Mindfulness based cognitive therapy
- Where
- 3 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- Leiden University Medical Center
Brachial Plexus Injury
Stem Cell Therapy to Improve the Muscle Function of Patients With Partly Denervated Muscles of the Arm
The purpose of this study is to assess muscle improvement after stem cell injection in the biceps muscle of patients with a brachial plexus injury.
- Trial name
- NCT00755586
- Testing
- Mononuclear cell injection: 4 * 10e8 cells, Mononuclear cell injection: 8 * 10e8 cells, No mononuclear cell injection
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Leiden University Medical Center
Uveal Melanoma
Treatment Of Radiation Retinopathy Trial
The purpose of this study is to demonstrate a statistically significant improvement of visual acuity after treatment using either Lucentis® or Triamcinolone® compared to no treatment, in patients with radiation retinopathy.
- Trial name
- TORR (NCT00811200)
- Testing
- ranibizumab, triamcinolone acetonide
- Volunteers
- 220 people
- Sponsor
- Leiden University Medical Center
Thyroid Cancer
Sorafenib as Adjuvant to Radioiodine Therapy in Non-Medullary Thyroid Carcinoma
The purpose of this study is to assess whether therapy with Sorafenib reinduces radioiodine uptake in thyroid carcinoma.
- Trial name
- NCT00887107
- Testing
- Sorafenib (nexavar)
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Leiden University Medical Center
Chronic Kidney Disease, Insulin Resistance
Rosiglitazone and Insulin Resistance in Renally Impaired Patients
30 non-diabetic, non-obese patients with stage 4 chronic kidney disease will be asked to participate in this metabolic study. The primary aim of this study is to determine the effect of rosiglitazone on insulin resistance in…
- Trial name
- NCT00452166
- Testing
- rosiglitazone
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Chronic Kidney Disease, Inflammation
Anti-Inflammatory Effects of Rosiglitazone in Patients With Stage 4 and 5 Chronic Kidney Disease
The purpose of this study in patients with stage 4 and 5 chronic kidney disease is to determine whether rosiglitazone can reduce inflammatory markers and to investigate its effect on intima media thickness, calcification and…
- Trial name
- Hercules (NCT00169923)
- Testing
- rosiglitazone
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Leiden University Medical Center
Insulin Resistance, Dyslipidemia
Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans
We hypothesized that short-term treatment with AP drugs induces insulin resistance through a mechanistic route that is independent of weight gain and that atypical drugs exert stronger effects than typical compounds in this…
- Trial name
- NCT00625170
- Testing
- olanzapine, Haloperidol
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Aortic Aneurysm, Abdominal
The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
The matrix metalloproteinase-9 (MMP-9) is considered to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline has direct MMP-9 inhibiting properties in vitro, and it effectively suppresses AAA development…
- Trial name
- NCT00538967
- Testing
- doxycycline
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Rheumatoid Arthritis
Rheumatoid Arthritis Patients in Training
Aim of the study was to investigate the effectiveness (functional ability and physical capacity) and safety (disease activity and damage of the joints) of long-term high-intensity weight-bearing exercises in patients with…
- Trial name
- RAPIT (NCT00434200)
- Testing
- long-term intensive exercise
- Volunteers
- 300 people
- Sponsor
- Leiden University Medical Center
Self-Injurious Behavior
The Efficacy of a Cognitive-Behavioural Intervention in Deliberate Self-Harm Patients
The purpose of this study is to evaluate whether the proposed cognitive-behavioural intervention is effective for DSH patients in the age group 15-35 years.
- Trial name
- NCT00169884
- Testing
- cognitive-behavioural therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Leiden University Medical Center
Chronic Obstructive Pulmonary Disease
Modification Of Disease Outcome In COPD
The hypothesis to be tested of this study is that treatment with fluticasone propionate leads to an initial improvement in symptoms, quality of life and lungfunction and a reduction in airways hyperresponsiveness.
- Trial name
- NCT00158847
- Testing
- fluticasone 500 mcg, fluticasone 500 mcg + salmeterol 50 mcg
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Leiden University Medical Center
Asthma
Asthma Management Project University Leiden
The long-term course of asthma shows variable outcome with regard to the incidence of exacerbations and the decline of lung function over time. The present study aimed: 1.
- Trial name
- NCT00279188
- Testing
- Guiding therapy by bronchial hyperrsponsiveness
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Leiden University Medical Center
Asthma, Chronic Obstructive Pulmonary Disease
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma
Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration.
- Trial name
- NCT00279136
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Disability, Occupational Therapy
Randomised Controlled Trial of Unsolicited Occupational Therapy in Community-Dwelling Elderly
In this study we aim to assess whether unsolicited occupational therapy compared to no therapy can decelerate the increase in disability in high-risk elderly.
- Trial name
- NCT00278096
- Testing
- occupational therapy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center