Clinical trials: sponsored by Loma Linda University
Hypersensitivity Reactions
Conventional Prophylactic Oral Dexamethasone vs Short-course IV Dexamethasone in Paclitaxel Hypersensitivity
This study is a single center, prospective, randomized, open-label study aimed at determining the most effective means of preventing hypersensitivity reactions in gynecologic oncology patients receiving paclitaxel infusions.
- Trial name
- NCT03598426
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Loma Linda University
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University
Gingival Inflammation
Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index
Objectives: To assess the change in gingival index (GI) and plaque index (PI) when comparing the use of toothpaste tablets to conventional toothpaste.
- Trial name
- NCT05805865
- Testing
- Toothpaste Tablet, Conventional Toothpaste
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Bone Loss, Implant Complication
The Effects of Dis/Reconnection of Implant Abutments on Peri-implant Bone Levels
The aim of this study was to evaluate the effects of definitive abutment connection at the time of implant placement on peri-implant bone levels and soft tissue changes in posterior maxilla and mandible regions.
- Conditions
- Bone Loss, Implant Complication, Gingival Recession
- Trial name
- NCT04043286
- Testing
- Definitive abutment
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Anxiety, Dental, Dental Decay
A Comparison of Oral Sedation-related Events of Three Multiagent Oral Sedation Regimens in Pediatric Dental Patients
This study will compare the post sedation events from three different multi-drug oral sedation regimens in order to help pediatric dentists determine the best course of action for their patients and prepare parents appropriately…
- Trial name
- NCT05126459
- Testing
- Regimen 1, Regimen #2, Regimen #3
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Loma Linda University
Carcinoma, Hepatocellular
Transarterial Chemoembolization Versus Proton Beam Radiotherapy for the Treatment of Hepatocellular Carcinoma
Patients with liver tumor burden that exceeds Milan criteria are considered to receive one of the following locoregional treatments: transarterial chemoembolization (TACE), radiofrequency ablation (RFA), percutaneous ethanol…
- Trial name
- NCT00857805
- Testing
- Transarterial Chemoembolization, Proton Beam Radiotherapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Loma Linda University
Chronic Pain
Effects of Electrotherapy on Pain, Anxiety, Motion and Disability in Adults With Neck or Upper Body Pain.
This will be a prospective randomized controlled trial with sixty adults, 20 to 40 years of age. There will be three groups as follows: the normal group, control group, and intervention group where subjects will receive…
- Trial name
- NCT05382039
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Missing Teeth
A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials.
The purpose of this investigator-initiated study is to compare new bone formation through histomorphometric analysis following maxillary sinus augmentation using two different bone graft materials.
- Trial name
- NCT03059914
- Testing
- InterOss, Bio-oss
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Urinary Tract Diseases
Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures
A prospective, randomized controlled study to determine the efficacy of liposomal bupivacaine given by local injection at all the wound sites in patients undergoing urologic surgeries.
- Trial name
- NCT02805504
- Testing
- Exparel, Marcaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Loma Linda University
Autism Spectrum Disorder
Mindfulness for Parents of Children With Autism Spectrum Disorder Autism Spectrum Disorder
The current study examines the efficacy of Mindfulness-Based Stress Reduction (MBSR) to reduce parenting stress, lessen parental reactivity and negativity, and decrease child externalizing behaviors among families of children…
- Trial name
- ASD (NCT03459625)
- Testing
- Mindfulness-Based Stress Reduction (MSBR), Psychoeducational Support Group (PE)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Loma Linda University
Early-Stage Breast Cancer
Proton Therapy for Early Stage Breast Cancer
The purpose of this study is to determine if partial breast proton therapy is effective treatment for early stage breast cancer following lumpectomy.
- Trial name
- NCT00614172
- Testing
- Proton radiation therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Soft Tissue Sarcoma
A Phase II Trial of Preoperative Proton Therapy in Soft-tissue Sarcomas of the Extremities and Body Wall
When treated with surgery alone, many soft-tissue sarcomas have a high chance of coming back. Radiation therapy is frequently used in addition to surgery to reduce the chances of the sarcoma coming back.
- Trial name
- NCT01819831
- Testing
- proton radiation, surgery (wide local excision; limb preservation surgery)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Loma Linda University
Prostate Cancer
Study of Hypofractionated Proton Beam Radiation Therapy for Prostate Cancer
The purpose of this study is to determine hypofractionated conformal proton beam radiation therapy of prostate cancer can achieve similar treatment benefits as our current institutional standard with conventional fractionation.
- Trial name
- NCT00831623
- Testing
- Proton Radiation, Proton
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Loma Linda University
Post Traumatic Stress Disorder, Depression
Does an Occupational Therapy Program Enhance Mental Health Outcomes for Veterans Who Scuba Dive
The purpose of the study is to investigate whether an occupational therapy program could enhance mental health outcomes for veterans who SCUBA dive.
- Conditions
- Post Traumatic Stress Disorder, Depression, Anxiety, Stress, Psychological
- Trial name
- NCT03928392
- Testing
- SCUBA with Occupational Therapy (OT), Self-Contained Underwater Breathing Apparatus (SCUBA) without OT
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Loma Linda University
Periodontitis, Chronic
Adjunctive Hydrogen Peroxide for Periodontal Therapy
There have been many adjunctive treatments for the additional clinical benefits to scaling and root planing (SRP) in the treatment of chronic periodontitis.
- Trial name
- AHP (NCT03262701)
- Testing
- Hydrogen Peroxide Gel, 13 weeks, Hydrogen Peroxide Gel, 26 weeks, Scaling and Root planing group
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Laparoscopic Donor Nephrectomy
Port Site Pain Following Percutaneous Externally-Assembled Laparoscopic Donor Nephrectomy
A single-arm prospective internally-controlled study. Patients will undergo Percutaneous Externally-Assembled Laparoscopic (PEAL) donor nephrectomy where one or more 3 mm instruments are added or substituted for conventional 5 or…
- Trial name
- NCT02805517
- Testing
- Percuvance™ Percutaneous Surgical System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Loma Linda University
Retinal Detachment
Use of Ocular Point of Care Ultrasound in Diagnosing Retinal Detachment in the Emergency Department
The study is collecting data along with other academic institutions regarding the accuracy of ocular ultrasound in diagnosing retinal detachment.
- Trial name
- RDOcularUS (NCT03106025)
- Testing
- Ultrasound, Ophthalmology Assessment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Outpatient Surgery, Pain, Postoperative
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Patient's pain level and narcotic requirements will be evaluated after routine outpatient Otolaryngology procedures. This will be done by having study participants record their pain level and medication usage from home.
- Trial name
- NCT03404518
- Testing
- Norco, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Carcinoma, Hepatocellular
Proton Radiotherapy Plus Sorafenib Versus Sorafenib for Patients With HCC Exceeding San Francisco Criteria
This study is designed to determine whether proton beam radiotherapy plus Sorafenib compared to Sorafenib alone will produce the best results for treating patients with Hepatocellular Carcinoma.
- Trial name
- HCC (NCT01141478)
- Testing
- Proton Beam Radiotherapy, Sorafenib
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Loma Linda University
Pancreatic Cancer
Chemotherapy Plus Proton-chemotherapy for Locally Advanced Pancreatic Cancer
The current trial will provide important data on the recurrence rates and patterns of failure using state of the art target agent, chemotherapy and proton beam technology for patients with Locally Advanced Pancreatic Cancer…
- Trial name
- NCT01683422
- Testing
- Proton, Gemcitabine, Erlotinib, Capecitabine, Proton Radiation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Loma Linda University