Clinical trials: sponsored by Lund University
Diffuse Large B-cell Lymphoma
Valproate as First Line Therapy in Combination With Rituximab and CHOP in Diffuse Large B-cell Lymphoma
Patients with previously untreated diffuse large B-cell lymphoma will receive standard treatment with R-CHOP (rituximab,cyclosphosphamide, doxorubicin, vincristine, and prednison) for 6 cycles, cycle length is 14 or 21 days.
- Trial name
- VALFRID (NCT01622439)
- Testing
- Valproate, Rituximab, Cyclophosphamide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University Hospital
Athletic Injuries
The Sports-Related Injuries and Illnesses in Para-sport Study (SRIIPS)
The overall aim of this project is to gain an in-depth understanding of the epidemiology of sports-related injuries and illnesses in parasport in order to assist the identification and development of specific injury prevention…
- Trial name
- NCT02788500
- Testing
- Incidence of sports-related injuries and illnesses
- Where
- Sweden
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Lund University
Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
Using NT-proBNP to Detect Chronic Heart Failure in Patients With Chronic Obstructive Pulmonary Disease
The aim of the present study was to evaluate if the analysis of NT-proBNP might be used as an initial step for the diagnosis of chronic heart failure in patients with COPD in primary health care, and to select patients for a…
- Trial name
- NT-proBNP (NCT01801722)
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Lund University
Insulin Resistance
Efficacy of a Bilberry-based Probiotic Product on Glucose Tolerance and Insulin Resistance
The impact of a bilberry-based probiotic drink on the postprandial levels of serum glucose and insulin have already been study in the past.
- Trial name
- NCT03185676
- Testing
- Bilberry, beverage without bilberries or probiotics
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Lund University
Brain Ischemia, Reduction of Cerebral Air Emboli
Comparative Effectiveness of Unilateral vs. Bilateral Pulmonary Collapse in Cardiac De-airing
To compare the effectiveness of unilateral pulmonary collapse (right lung) to bilateral pulmonary collapse for cardiac de-airing in open left-sided heart surgery.
- Trial name
- NCT02119871
- Testing
- Bilateral Open Pleurae, Right Pleura Open
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Lund University
Metabolic Disorders and Cognitive Decline
Effects of Whole Grain Rye on Metabolic Risk Markers and Mood
The purpose of the study is to investigate, in healthy middle age subjects, effects of whole grain rye on cognitive functions, mood, and cardiovasculair risk markers
- Trial name
- NCT03275948
- Testing
- whole grain, reference
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lund University
Psychological Stress
Relationship Between the Gut Microbiota and Stress
The relationship between the gut microbiota and stress is poorly studied in humans. In this study we aim to look for if stressed persons have different levels of key bacterial groups compared to the levels in non-stressed persons.
- Trial name
- NCT02378610
- Testing
- Observation
- Where
- Sweden
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Lund University
Cognitive Performance, Mood
Effects on Cognitive Functions and Mood of Food Products Rich in Polyphenols
The purpose of this study is to investigate effects of a selected food product rich in polyphenol on cognitive performance and mood.
- Conditions
- Cognitive Performance, Mood, Cardiometabolic Risk Markers
- Trial name
- NCT02243956
- Testing
- Flavanol rich food product
- Where
- Sweden
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lund University
Stress
Gut Permeability and Stress
The purpose of this study is to analyse gut permeability and stress.
- Trial name
- SP15 (NCT02485405)
- Testing
- Trier social stress test
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Lund University
Small Cell Lung Cancer
A Study of Standard Treatment +/- Enoxaparin in Small Cell Lung Cancer
The endpoint is to investigate if the addition of low molecular heparin - enoxaparin, will result in a significant increase of overall survival in patients with small cell lung cancer, receiving standard chemotherapy.
- Trial name
- RASTEN (NCT00717938)
- Testing
- cisplatinum or carboplatin and e.g.etoposide., cisplatinum or carboplatin and e.g.etoposide+enoxaparin
- Where
- 16 sites in Sweden
- Volunteers
- 390 people
- Sponsor
- Lund University Hospital
Stable Claudication (Fontaine IIa and IIb), Superficial Femoral Artery Disease
Primary Stenting vs Conservative Treatment in Claudicants - a Study on Quality of Life
The aim of this study is to evaluate whether primary stenting with self expanding stent in patients with peripheral arterial disease suffering from stable claudication due to superficial femoral artery disease results in improved…
- Conditions
- Stable Claudication (Fontaine IIa and IIb), Superficial Femoral Artery Disease, Best Medical Treatment, Quality of Life Scores at 12 and 24 Months
- Trial name
- NCT01230229
- Testing
- Stenting, Best medical treatment
- Where
- 2 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University
Type 2 Diabetes
DPP-4 Inhibition, Incretins and Islet Function
Hypothesis is that DPP-4 inhibition affects glucose levels through changes in incretin and islet hormones. The study examines this in relation to breakfast, lunch and dinner over an entire 24h study period by the use of three…
- Trial name
- CODI24 (NCT02089438)
- Testing
- Saxagliptin, Vildagliptin, Sitagliptin
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Lund University
Abdominal Obesity, Cardiovascular Diseases
Grain Exercise Trial - Whole Grain Versus no Grain With or Without Physiotherapy-promoted Exercise for Waist Loss
The main purpose of this 2-year lifestyle experiment for waist loss is twofold: 1. to compare whole grains and no grains as part of a healthy diet, 2.
- Conditions
- Abdominal Obesity, Cardiovascular Diseases, Diabetes Type 2, Hypertension
- Trial name
- GET (NCT01208558)
- Testing
- Diet A, Diet B, Physiotherapy
- Where
- Sweden
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Lund University
Postprandial Hyperglycemia
Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance
Consumption of polyphenol-rich fruits and vegetables may improve the postprandial glucose and insulin responses and hence promote well-being.
- Trial name
- NCT03159065
- Testing
- Bilberry, Blackcurrant, Mango
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lund University
Chronic Lymphocytic Leukemia
Pretreatment With Valproate Prior to Immunotherapy Targeting Cluster of Differentiation Antigen 20 in Chronic Lymphocytic Leukemia
This trial includes patients with chronic lymphocytic leukemia, the most common kind of malignant lymphoma. Monoclonal antibodies directed against cluster of differentiation antigen 20 have improved treatment results in different…
- Trial name
- PREVAIL (NCT02144623)
- Testing
- Valproate
- Where
- Sweden
- Volunteers
- 4 people
- Sponsor
- Lund University Hospital
Stress Reaction
The Effects of Lactobacillus Plantarum on Cortisol, IgA and Alpha-amylase Levels in Human Saliva During Stress
In the present study the main goal has been to clarify the effect of the probiotic bacteria Lactobacillus plantarum 299v on the salivary cortisol level in young adults under examination stress.
- Trial name
- NCT02974894
- Testing
- Probiotic (Lactobacillus Plantarum)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Lund University
Hyperglycemia, Coronary Heart Disease
Paleolithic Diet in the Treatment of Glucose Intolerance
The purpose of this study is to determine whether a paleolithic diet improves glucose tolerance and insulin sensitivity in people with coronary heart disease and impaired glucose tolerance.
- Trial name
- NCT00419497
- Testing
- Paleolithic diet vs Mediterranean diet
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Poor Glycemic Control
Food Design for Improved Day-long Glycaemic Regulation
The study focus is on the possible improvement in glucose tolerance at a second standardized meal that can be achieved when preceded by a test meal with a low GI and a high GP.
- Trial name
- NCT02876029
- Testing
- Reference, Test product
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Infantile Colic
Acupuncture in Infantile Colic - a Three Armed Randomized Multi Center Trial (ACU-COL)
The purpose of this prospective randomized three armed, multi center study is to compare the effect of two types of acupuncture and no acupuncture in 2-8 weeks old infants with infantile colic.
- Trial name
- ACU-COL (NCT01761331)
- Testing
- Acupuncture
- Where
- 4 sites in Sweden
- Volunteers
- 147 people
- Sponsor
- Lund University