Clinical trials: sponsored by Mahidol University
Community-acquired Pneumonia
Effectiveness of the PCV13 in Older Thai Adults
This is the matched 1:2 case-control study, prospectively collect case and control who are diagnosed with pneumococcal or non-pneumococcal community acquired pneumonia (CAP), accordingly from November 2023 through October 2024.
- Trial name
- NCT06279624
- Where
- Thailand
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Nodules, Ultrasonography
Ultrasonographic Patterns and Pathological Correlation in the Diagnosis of Subcutaneous Nodules
The objective of this study is to explore the role of ultrasonography (non-invasive imaging device) in the diagnosis of subcutaneous nodules (mass/bumb underneath the skin).
- Conditions
- Nodules, Ultrasonography, Panniculitis
- Trial name
- NCT06838988
- Testing
- Transcutaneous ultrasound
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Wheat Hypersensitivity, Immunotherapy
Comparison Efficacy Between Two Different Frequency of Maintenance Dose Oral Immunotherapy
Oral immunotherapy(OIT) is effective in desensitized food allergy. OIT protocols are not standardized, and a wide heterogeneity exists in the literature .
- Trial name
- NCT06035328
- Testing
- Wheat (Four times per week)
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Mahidol University
Atrial Fibrillation
COhort of antithrOmbotic Use and cLinical Outcomes in Patients With Atrial Fibrillation (COOL-AF) Phase 2
Atrial fibrillation (AF) is a leading cause of cardiovascular mortality and morbidity. Asian patients with AF have a higher rate of major bleeding including intracranial hemorrhage (ICH) compared to non-Asians.
- Trial name
- NCT06396299
- Testing
- No intervention
- Where
- 33 sites in Thailand
- Volunteers
- 4,000 people
- Sponsor
- Mahidol University
Low Back Pain
Corticospinal and Motor Behavior Responses After Physical Therapy Intervention in Patients With Chronic Low Back Pain.
This study aims to 1) determine the immediate effects of transcranial direct current stimulation (tDCS) on corticospinal excitability, lumbar multifidus muscle (LM) activation, as well as lumbar stability in patients with chronic…
- Trial name
- NCT05156242
- Testing
- Active-tDCS priming MCE, NMES priming MCE, Conventional physical therapy
- Where
- Thailand
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Laparoscopic Bariatric Surgery
Intraoperative Lidocaine and Combined With Ketamine on Opioid After Bariatric Surgery
The most effective long-term treatment for obesity is bariatric surgery, however, postoperative pain control is challenging in these group of population.
- Trial name
- NCT04524130
- Testing
- Lidocaine Hydrochloride, Ketamine
- Where
- Thailand
- Volunteers
- 87 people
- Sponsor
- Mahidol University
Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Thailand ATTR-CM Registry
The investigators of this registry aim to study the natural history, clinical presentation, characteristics, and imaging findings of patients diagnosed with ATTR amyloidosis in Thailand longitudinally.
- Trial name
- NCT06338696
- Testing
- No intervention
- Where
- 8 sites in Thailand
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Mahidol University
COPD
The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD
This study aims to demonstrate the effects of triple therapy (ICS/LABA/LAMA) and dual bronchodilators (LAMA/LABA) on air trapping in the lungs' COPD patients and inflammatory mediators
- Trial name
- NCT06474039
- Testing
- Trelegy or Anoro
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Mahidol University
Critical Illness, Fluid Over-load
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care.
- Conditions
- Critical Illness, Fluid Over-load, Dynamic Arterial Elastance, Septic Shock
- Trial name
- DAFM shock (NCT06937918)
- Testing
- The AFM and Eadyn - guided resuscitation group, The standard care for septic shock
- Where
- 3 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
EIT-Guided Ventilator Settings in AHRF
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and…
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NCT06936618
- Testing
- Electrical Impedance Tomography (EIT), Enlight 2100
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University
Atopic Dermatitis, Food Allergies
Frequency of Food Allergy Confirm by Oral Food Challenge Among Foods Avoidance in Atopic Dermatitis Children
Atopic dermatitis can be caused by several factors, including food allergy. Currently, the diagnosis of food allergy often performing skin tests and measuring specific IgE foods that many studies have shown that about 53% of…
- Trial name
- NCT06947252
- Testing
- Oral food challenge test
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Lower Urinary Tract Symptoms, Female Genitourinary Disease
Efficacy of Vaginal 17β-Estradiol on the Urinary Storage Symptoms in Postmenopausal Women
The goal of this clinical trial is to evaluate whether vaginal 17β-estradiol effectively treats storage symptoms of lower urinary tract symptoms (LUTS) and enhances quality of life.
- Conditions
- Lower Urinary Tract Symptoms, Female Genitourinary Disease, Urinary Stress Incontinence, Urinary Urge Incontinence
- Trial name
- NCT06508944
- Testing
- vaginal 17 beta-estradiol, Behavioral modifications
- Where
- Thailand
- Volunteers
- 86 people
- Sponsor
- Mahidol University
Safety Issues, Dengue
Safety, Virological and Immunological Assessment of the Controlled Dengue Human Infection Model in Dengue-Immune Participants in Thailand (DHIT-Immune)
rDEN2Δ30-7169 is a dengue challenge strain that previously reports its viremia induction effect in participants with minimal symptoms in US flavivirus naïve participants.
- Conditions
- Safety Issues, Dengue, Viremia, Immune-related Adverse Event
- Trial name
- DHIT-Immune (NCT06908018)
- Testing
- rDEN2Δ30-7169
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Vaginal Laxity
Fractional Bipolar Radiofrequency Therapy VS Sham for Treatment of Vaginal Laxity in Premenopausal Women
Knowledge gap: Lack of randomized controlled trials evaluating the efficacy of fractional bipolar radiofrequency therapy compared to a sham treatment for vaginal laxity in premenopausal women.
- Trial name
- NCT06872281
- Testing
- Fractional bipolar radiofrequency
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Mahidol University
Irritable Bowel Syndrome (IBS), Constipation - Functional
Effect of a Low FODMAP Diet in IBS and Functional Constipation with Bloating: a Randomized Double-Blind Trial
This clinical study aims to evaluate the effects of a low FODMAP diet compared to a high FODMAP diet in patients with Irritable Bowel Syndrome (IBS) and Functional Constipation (FC) with predominant bloating.
- Conditions
- Irritable Bowel Syndrome (IBS), Constipation - Functional, Bloating
- Trial name
- NCT06871748
- Testing
- Low FODMAP Diet, High FODMAP Diet
- Volunteers
- 34 people
- Sponsor
- Mahidol University
Chemotherapy Induced Nausea and Vomiting
Olanzapine Versus Placebo for Moderately Emetogenic Chemotherapy
A study comparing efficacy of olanzapine versus placebo to prevent nausea and vomiting from moderate emetic risk chemotherapy
- Trial name
- NCT06850454
- Testing
- olanzapine
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Mahidol University
Usability Satisfaction
Comparison of Usability Satisfaction of the Newly Developed Low-cost Thermoplastic Splint and Commercial Thermoplastic Splint
Low-temperature thermoplastic has been commonly used in the fabrication of hand splints. However, its high cost and limited accessibility pose challenges for both clinicians and clients.
- Trial name
- NCT06843746
- Testing
- Commercial thermoplastic, Newly developed low-cost thermoplastic
- Where
- Thailand
- Volunteers
- 112 people
- Sponsor
- Mahidol University
Non-carious Cervical Lesion
Clinical Evaluation of Composite Restorations Using Two-steps Universal Adhesive in Non-carious Cervical Lesion (NCCL)
The goal of this clinical study is to compare the clinical performance of a new 2-steps universal adhesive in patients with non-carious cervical lesions.
- Trial name
- NCCL (NCT05573243)
- Testing
- bonding strategies
- Where
- Thailand
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Mahidol University
AKI - Acute Kidney Injury
Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane
This study is a general pharmacokinetic investigation of vancomycin in patients receiving continuous veno-venous hemodiafiltration (CRRT) with the oXiris membrane.
- Trial name
- NCT06543940
- Testing
- Vancomycin
- Where
- Thailand
- Volunteers
- 8 people
- Sponsor
- Mahidol University
Lung Cancer - Non Small Cell, Lung Cancer (NSCLC)
Standard Care With or Without Early Palliative Care Provided by Palliative Care Specialist in Advanced Non-small Cell Lung Cancer Patients
Early palliative care has been shown to improve the survival of advanced lung cancer patients. However, most of the clinical studies were performed in the era when systemic treatment options for this disease were limited.
- Trial name
- NCT06786468
- Testing
- Early palliative care integration, Standard systemic treatment for advanced lung cancer
- Where
- Thailand
- Volunteers
- 104 people
- Sponsor
- Mahidol University