Clinical trials: sponsored by Massachusetts General Hospital
Pollution; Exposure, Hypertension
Solar Lighting to Reduce Indoor Air Pollution in Rural Uganda
This study evaluates the impact of a solar lighting system on kerosene lamp use, levels of indoor air pollution, and health in women living in rural Uganda.
- Conditions
- Pollution; Exposure, Hypertension, Pollution Related Respiratory Disorder
- Trial name
- NCT03351504
- Testing
- Solar lighting system
- Where
- 2 sites in United States, Uganda
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Health Insurance, Childhood Cancer Survivors
Developing a Health Insurance Navigation Program for Survivors of Childhood Cancer
Dr. Park and her colleagues published findings in the Journal of Clinical Oncology demonstrating that CCSS survivors, compared to siblings, were significantly more likely to be uninsured and to have difficulties obtaining health…
- Trial name
- HINT (NCT04520061)
- Testing
- Health Insurance Navigation Program
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognitive Impairment, Dementia
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems.
- Trial name
- MarkVCID (NCT06284213)
- Testing
- No interventions
- Where
- 17 sites in United States
- Volunteers
- 1,892 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases, Acute Coronary Syndrome
MBCT Via Group Videoconferencing for Acute Coronary Syndrome Patients With Depressive Symptoms: A Pilot RCT
The aim of this study is to establish, in a pilot RCT (approx. N=50 participants) with a time- and attention-matched health enhancement control, (a) the feasibility of the recruitment procedures (screening, eligibility…
- Conditions
- Cardiovascular Diseases, Acute Coronary Syndrome, Depression
- Trial name
- NCT04799899
- Testing
- Adapted MBCT, Cardiac Health Enhancement
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Pediatric Bipolar Disorder, Pediatric OCD
Fluoxetine for Obsessive-Compulsive Disorder in Children and Adolescents With Bipolar Disorder
This will be a 12-week open-label pilot treatment study for children and adolescents (ages 6-17) who meet DSM-IV criteria for bipolar disorder (BPD) and obsessive-compulsive disorder (OCD) who are adequately mood stabilized on a…
- Trial name
- NCT00592852
- Testing
- fluoxetine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Living in Families With Emotions
School-Based Living In Families With Emotions Training
The overall purpose of this study is to identify adolescents who are at-risk for psychosis, as evidenced by endorsement of mild-to-moderate, sub-syndromal symptoms, and provide them with a potentially preventive intervention…
- Trial name
- NCT06793878
- Testing
- Living in Families With Emotions
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Chronic Low-back Pain, Low Back Pain
Using Non-Weightbearing Stationary Elliptical Machines for Patients with Chronic Low Back Pain
The goal of this clinical trial is to assess the effect of non-weightbearing stationary ellipticals (Cubii, Fitness Cubed, Inc.) on patient well-being with chronic lower back pain (CLBP).
- Trial name
- Cubii (NCT05724160)
- Testing
- Using sitting ellipticals, Physiotherapy Protocol
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer Screening
Promoting Informed Decisions About Cancer Screening in Older Adults
This project aims to examine the impact of different interventions designed to help individualize colorectal cancer (CRC) screening decisions in adults aged 76-85. Clinicians will be assigned by chance to one of two arms.
- Trial name
- PRIMED (NCT03959696)
- Testing
- Notification, Training
- Where
- 5 sites in United States
- Volunteers
- 536 people
- Sponsor
- Massachusetts General Hospital
Physiological Stress
Operational Performance Effects and Neurophysiology in Partial Gravity
Aim 1: Characterize and quantify changes in operationally-relevant sensorimotor and vestibular performance as a function of gravitational load.
- Trial name
- OPEN-PG (NCT06736652)
- Testing
- Parabolic flight
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorders
Magnetic Resonance Spectroscopic and Diffusion Tensor Imaging of Adolescents with Autism Spectrum Disorders
The primary objective of this study is to conduct magnetic resonance spectroscopic (MRS) and imaging (MRI) scans to assess the structural and neurochemical profile of the brain in 20 children and adolescents, 6-17 years old with…
- Trial name
- NCT01361503
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Thyroid Cancer, Thyroid Carcinoma
Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC
This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-refractory thyroid cancer.
- Conditions
- Thyroid Cancer, Thyroid Carcinoma, Metastatic Thyroid Cancer, Follicular Thyroid Cancer
- Trial name
- NCT05668962
- Testing
- Selpercatinib, Sodium Iodine I-131, rhTSH
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Malignant Glioma, Anxiety
Psychological Intervention For Brain Tumor Caregivers
This study is testing a supportive psychosocial intervention for caregivers of people who have malignant brain tumors such as gliomas or other high-grade primary brain tumors.
- Conditions
- Malignant Glioma, Anxiety, Caregiver Burden, Malignant Brain Tumor
- Trial name
- NCT04109209
- Testing
- Psychosocial Intervention Group, Usual Care Group
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Adolescent Behavior, Substance Use
Evaluating the Effectiveness of a Drug Education and Diversion Program for Middle and High School Students
The primary goal of this study is to evaluate the effectiveness of the iDECIDE curriculum as an alternative to punitive responses for school-based substance use infractions.
- Conditions
- Adolescent Behavior, Substance Use, Youth, Health Risk Behaviors
- Trial name
- iDECIDE (NCT05321563)
- Testing
- iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Massachusetts General Hospital
Williams Syndrome, Anxiety
Buspirone Treatment of Anxiety in Williams Syndrome
The purpose of this study is to do a preliminary assessment of whether buspirone is effective, safe, and tolerable in the treatment of anxiety in children, adolescents, and adults with Williams syndrome.
- Trial name
- NCT04807517
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Kidney Failure, Hepatitis C
QUICKly Eradicate Hepatitis C in Patients Undergoing REnal Transplant With 4 Weeks of Glecaprevir/Pibrentasvir
This is a single center study characterizing the experience of administration of 4 weeks of pan-genotypic DAA therapy in kidney transplantation to prevent the transmission of hepatitis C virus infection from an HCV-positive donor…
- Conditions
- Kidney Failure, Hepatitis C, Kidney Disease, Chronic
- Trial name
- QUICK-CURE (NCT04515797)
- Testing
- Glecaprevir and Pibrentasvir
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Mental Health
Seguimos Avanzando - Latino Youth Coping With Discrimination
The overall objective of this study is to investigate mediators and moderators at multiple ecological (individual, family/peer and school/neighborhood levels) and time-scale (micro- and macro-time) levels in the link between…
- Trial name
- NCT04875208
- Where
- United States
- Volunteers
- 886 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Facial Trauma, Facial Deformity
Face Transplantation
Face allotransplantation will be performed in facial trauma patients. Immune suppression will primarily be provided according to standard three-drug regimen.
- Conditions
- Facial Trauma, Facial Deformity, Facial Injuries
- Trial name
- NCT05699187
- Testing
- Face allotransplantation
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Digital Health Interventions for Obsessive Compulsive Disorder (OCD)
The investigators are testing two digital health interventions for obsessive compulsive disorder (OCD). The investigators hope that these digital health programs will increase access to treatment for OCD.
- Trial name
- NCT04136626
- Testing
- Perspectives OCD, The Health and Well-Being Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Non Small Cell Lung Cancer, Quality of Life
Supportive Care Mobile Application for Patients With NSCLC
This research study is looking at the role of a supportive care mobile app in improving symptoms, coping skills, and quality of life in patients with non-small cell lung cancer.
- Conditions
- Non Small Cell Lung Cancer, Quality of Life, Coping Skills
- Trial name
- NCT04629300
- Testing
- Supportive Care Mobile Application, Usual Care
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Hypertrophy, Left Ventricular, Hypertension
Effect of a Targeted Notification and Clinical Support Pathway on Individuals With Left Ventricular Hypertrophy
The electronic health record contains vast amounts of cardiovascular data, including potential clues that an individual may have unrecognized cardiac conditions.
- Conditions
- Hypertrophy, Left Ventricular, Hypertension, Cardiomyopathies
- Trial name
- NOTIFY-LVH (NCT05713916)
- Testing
- Intervention: Population Health Coordinator
- Where
- United States
- Volunteers
- 648 people
- Sponsor
- Massachusetts General Hospital
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