Clinical trials: sponsored by McMaster University
Mental Health Issue, Mental Stress
Evaluating Implementation and Impact of PeerOnCall, a Mobile Health Approach to Peer Support for Canadian Public Safety Personnel
A prospective cohort study design will be implemented across four sectors and multiple organizations sites to evaluate implementation and impact of the apps.
- Conditions
- Mental Health Issue, Mental Stress, Post Traumatic Stress Disorder
- Trial name
- NCT05429619
- Testing
- PeerOnCall
- Where
- 3 sites in Canada
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- McMaster University
Breast Cancer
Financial Toxicity in Breast Cancer Surgery
The purpose of this study is to evaluate financial toxicity, or financial harm, in breast cancer patients. The study will follow patients throughout their cancer treatment.
- Trial name
- NCT05104632
- Where
- 2 sites in Canada
- Volunteers
- 630 people
- Sponsor
- McMaster University
Complex Regional Pain Syndrome (CRPS)
Reducing Pain in Complex Regional Pain Syndrome Using Personalized Brain Stimulation: A Feasibility Study
This research study looks at the feasibility of using a new treatment, noninvasively activating the brain through repetitive transcranial magnetic stimulation (rTMS) to treat pain symptoms of complex regional pain syndrome…
- Trial name
- NCT06987747
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Loneliness
Impact of Pulmonary Rehabilitation on Loneliness in COPD
Loneliness is the feeling of sadness because one wants friends or company. This feeling is common in patients with chronic lung disease, who suffer from breathing difficulty, chronic cough, and reduced physical and mental health.
- Trial name
- NCT05435963
- Testing
- Pulmonary rehabilitation (PR)
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- McMaster University
Obesity, Risk Factors
Motivational Interviewing to Promote Healthy Behaviours in Young Adults
The overall goals of this project are to evaluate the feasibility of web-based nurse-led motivational interviewing and educational interventions to promote healthy behaviours for obesity prevention and maintenance of healthy…
- Trial name
- Motivate (NCT05264740)
- Testing
- Motivational interviewing, Educational materials
- Where
- Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- McMaster University
Acute Leukemia, Myelodysplasia
ATG Plus PTCy vs ATG for CGVHD Prophylaxis
A Randomized Pilot Trial to test the feasibility of comparing anti-thymocyte globulin plus post transplant cyclophosphamide with anti-thymocyte globulin alone to prevent chronic graft versus host disease.
- Conditions
- Acute Leukemia, Myelodysplasia, Chronic Graft-versus-host-disease
- Trial name
- NCT04202835
- Testing
- Cyclophosphamide, Anti-Thymocyte globulin (rabbit)
- Where
- 9 sites in Australia, Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Robot-Assisted Partial Knee Replacement Versus Standard Total Knee Replacement
This is a pilot randomized trial to assess the feasibility of a definitive trial to determine the effect of robot-assisted partial knee replacements versus standard total knee replacements.
- Trial name
- RoboKnees (NCT04378049)
- Testing
- Total knee arthroplasty, Robot-assisted partial knee arthroplasty
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- McMaster University
Atrial Fibrillation (AF), VTE
Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure
PAUSE 2 study is a prospective, open-label, blinded-endpoint non-inferiority RCT of PAUSE vs. ASRA management in DOAC treated high risk patients with AF/VTE who need elective high bleed risk surgery/procedure and/or any procedure…
- Trial name
- PAUSE 2 RCT (NCT06957366)
- Testing
- PAUSE Perioperative DOAC Management, ASRA Perioperative DOAC Management
- Where
- 14 sites in United States, Belgium and 2 more
- Volunteers
- 920 people
- Sponsor
- McMaster University
Chronic Cough (CC)
Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).
Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents.
- Trial name
- APEC (NCT06600646)
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
Public Health Nurse-Delivered 1-Day CBT Workshops for PPD
Public Health Nurses (PHN) received training to deliver a day-long Cognitive Behavioural Therapy (CBT)-based workshop for treating postpartum depression (PPD).
- Trial name
- NCT05622305
- Testing
- 1-Day Cognitive Behavioural Therapy-Based Workshop
- Where
- Canada
- Volunteers
- 451 people
- Sponsor
- McMaster University
Total Knee Arthroplasty, Osteoarthritis
Kinematic and Mechanical Alignment Randomized Trial
Knee replacement surgery is the second most common surgery in Canada. People who have very painful knee arthritis usually receive a knee replacement where the surgeon aims to make everyone's knee as straight as possible (called…
- Trial name
- KMART (NCT06787417)
- Testing
- Restricted Kinematically-aligned Arthroplasty, Mechanically-Aligned Arthroplasty
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- McMaster University
Autism Spectrum Disorder, Behavior Problem
The Family Check-Up in Autism Services
Many children and youth with autism spectrum disorder have high levels of emotional and behavioural problems. Parents play a powerful role in supporting their children's well-being.
- Conditions
- Autism Spectrum Disorder, Behavior Problem, Emotional Problem
- Trial name
- NCT05280613
- Testing
- Family Check-Up, Treatment as Usual
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- McMaster University
Diabetes, Gestational
A Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes
This trial will assess the impact of a culturally tailored, personalized nutrition intervention on glycemic response to an oral glucose load (as measured by the area-under-the curve glucose) in high-risk pregnancies of South…
- Trial name
- DESI-GDM (NCT03607799)
- Testing
- Dietary Intervention, Control
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Cough
Prospective Study on the Evaluation, Patient Reported Outcomes and Effectiveness of Treatment for Chronic Cough
Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents.
- Trial name
- PROCOUGH (NCT04758351)
- Testing
- Usual clinical practice
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Cerebrovascular Function, Cerebral Blood Flow
Mechanistic Effect of Ketones on Cerebral Blood Flow
Oral supplements containing exogenous ketones have recently become available and represent a novel tool for increasing plasma ketone bodies without the need for dietary restriction.
- Trial name
- MEKC (NCT06217159)
- Testing
- Poikilocapnia, Normocapnia
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- McMaster University
Autism Spectrum Disorder, Cerebral Palsy
READYorNot[TM] Brain-Based Disabilities Trial
The purpose of this study is to find out if there is a benefit to using the MyREADY Transition[TM] BBD App for brain-based disabilities, compared to not using it.
- Conditions
- Autism Spectrum Disorder, Cerebral Palsy, Epilepsy, Fetal Alcohol Spectrum Disorders
- Trial name
- NCT03852550
- Testing
- e-health application
- Where
- 9 sites in Canada
- Volunteers
- 52 people
- Sponsor
- McMaster University
Renal Failure, Hemodialysis
Dial-Bicarb Trial: Effects of a Lower vs. Higher Concentration of Dialysate Bicarbonate
This is a pragmatic, two-arm, parallel-group, open-label, individual-randomized, superiority trial that will be conducted in hemodialysis units across Ontario.
- Trial name
- NCT06270134
- Testing
- Bicarbonate
- Volunteers
- 14,000 people
- Sponsor
- McMaster University
Atrial Fibrillation (AF)
Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)
The purpose of the PAUSE-Virtual Study is to show that by changing pre-surgery visits with patients taking a blood thinner (direct oral anticoagulant (apixaban, dabigatran, edoxaban, rivaroxaban or warfarin) when the participant…
- Trial name
- PAUSEVirtual (NCT06844227)
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 1,780 people
- Sponsor
- McMaster University
Surgical Skill Training
Remote Video-Delivered Suturing Education with Smartphones
Medical students were randomized to receive live video- or recorded video-delivered feedback on suturing skills. A non-randomized control group received in-person feedback.
- Trial name
- REVISE (NCT06857266)
- Testing
- Live Video-delivered Feedback, In-Person Feedback, Recorded Video-delivered feedback
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Subjective Cognitive Decline
Β-OHB Supplementation and Brain Health in Older Adults
The goal of this randomized placebo controlled crossover trial is investigate the effects of short-term ketone monoester (KME) supplementation to brain function in older adults with subjective cognitive decline.
- Trial name
- NCT06588946
- Testing
- Ketone monoester (KME) supplement
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- McMaster University