Clinical trials: sponsored by McMaster University
Oxidative Stress, DNA Damage, Radiation Induced
Multi-Nutrient Supplement for Radio-Protection
Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells.
- Conditions
- Oxidative Stress, DNA Damage, Radiation Induced, Radiation Exposure
- Trial name
- MNSRP (NCT04781868)
- Testing
- Multi-nutrient supplement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Breast Cancer
Evaluating the Impact of Evidence-based Information About Mammography on Breast Cancer Screening Decisions
Patient decision aids are tools that help guide individuals through a healthcare-related decision making process. They help users combine evidence-based information and recommendations by a health care provider with their…
- Trial name
- NCT03631758
- Testing
- Evidence-based information, Patient Decision Aid
- Where
- Canada
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hydronephrosis, Urinary Tract Infection
Effectiveness of Antibiotics Versus Placebo to Treat Antenatal Hydronephrosis
This study focuses on the relationship between prophylaxis antibiotics and frequency of urinary tract infection in children diagnosed with antenatal hydronephrosis.
- Trial name
- ALPHA (NCT01140516)
- Testing
- Trimethoprim, Simple Syrup
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- McMaster University
Cryptorchidism
One Stage vs. Two Stage Gubernaculum Sparing Laparoscopic Orchidopexy (GSLO)
Undescended Testis (UDT) is the most common congenital anomaly of the genitalia in boys and it is commonly managed by surgical intervention.
- Trial name
- GSLO (NCT02936024)
- Testing
- Two-Stage GSLO Technique, One-Stage GSLO Technique
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Complex Regional Pain Syndrome
Treatment of Complex Regional Pain Syndrome
This study will investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) and a sensorimotor training task to treat symptoms of pain in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT05197959
- Testing
- Repetitive transcranial magnetic stimulation, Sensorimotor training
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Overweight and Obesity, Men
Evaluation of a Supplement for Weight Management in Obese and Overweight Individuals
The purpose of this trial is to examine the effects of a novel, orally consumed dietary supplement (composed of naturally occurring components) on weight management and metabolic rate in individuals who are overweight or obese…
- Conditions
- Overweight and Obesity, Men, Women
- Trial name
- NCT03812211
- Testing
- Active Supplement
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dementia, Burden, Caregiver
An Internet-Based Education Program for Care Partners of People Living With Dementia
With the aging population, the prevalence of dementia is increasing dramatically. People living with dementia are highly dependent on family care partners, who may have little knowledge of the disorder.
- Conditions
- Dementia, Burden, Caregiver, Self Efficacy, Knowledge
- Trial name
- NCT05114187
- Testing
- Education Intervention, Education Control
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- McMaster University
Prostate Cancer
Evaluating the Impact of Evidence-based Information About PSA Testing on Prostate Cancer Screening Decisions
Patient decision aids are tools that help guide individuals through a healthcare-related decision making process. They help users combine evidence-based information and recommendations by a health care provider with their…
- Trial name
- NCT03477591
- Testing
- Evidence-based information, Patient Decision Aid
- Where
- Canada
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- McMaster University
Drive
The Refreshing Older Adults' Driving Skills (ROADSkills) Program
Drivers aged 65+ depend on their car(s) to get to the places and see the people that are important to them. Losing a license in later life has been linked to higher rates of loneliness, depression, and even admission to long-term…
- Trial name
- ROADSkills (NCT05450159)
- Testing
- ROADskills program, Healthy Aging
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Myotonic Dystrophy 1
Home-based Training and Supplementation in DM1 Patients
Myotonic dystrophy type 1 (DM1) is a rare genetic disease that affects about 1 in 2100 people. Patients diagnosed with DM1 present with many symptoms, however, their muscles are mainly affected.
- Trial name
- DM1HBET (NCT05848830)
- Testing
- Mult-ingredient supplement, Concurrent exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mental Health Issue, Mental Stress
Beyond Silence: Advancing E-mental Health Solutions to Support Canadian Healthcare Workers
The purpose of this project is to scale implementation and evaluation of an m-health app designed to promote early intervention and mental health support for frontline healthcare workers to reduce their risk of post-traumatic…
- Conditions
- Mental Health Issue, Mental Stress, Post-traumatic Stress Disorder, Moral Injury
- Trial name
- NCT05514093
- Testing
- Beyond Silence App
- Where
- Canada
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hip Osteoarthritis
A Prospective Evaluation of the Cingal Injection for Hip Osteoarthritis
Osteoarthritis (OA) of the hip is one of the ten most disabling diseases in the developed world. Because OA gradually worsens over time, the sooner treatment is started, the more likely its impact is lessened.
- Trial name
- ECHO (NCT04084704)
- Testing
- Cingal
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Mobility Limitation, Fall Injury
Home-based HIFST for Older Adults to Prevent Functional Decline
After an injury, an older adult may experience changes to how they complete their daily activities and participate in physical activity.
- Conditions
- Mobility Limitation, Fall Injury, Slip and Fall
- Trial name
- NCT05266911
- Testing
- high-intensity functional strength training, Lower extremity stretching
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Aging
Improving Physical Activity and Mobility Via Live Online Exercise Sessions for Older Adults
The COVID-19 pandemic has undoubtedly resulted in an increased level of personal anxiety, reduced access to support services, and as a secondary complication, increased physical inactivity.
- Trial name
- NCT04627493
- Testing
- Online exercise
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
Public Health Nurse-Delivered 1-Day CBT Workshops Pilot
Public Health Nurses received training to deliver a day-long Cognitive Behavioural Therapy-based workshop for treating postpartum depression.
- Trial name
- NCT05314361
- Testing
- 1-Day Cognitive Behavioural Therapy-Based Workshop
- Where
- Canada
- Volunteers
- 119 people
- Sponsor
- McMaster University
Preterm Birth, Complication of Prematurity
Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities, such as respiratory distress syndrome, in preterm infants.
- Conditions
- Preterm Birth, Complication of Prematurity, Obstetric Labor, Premature, Obstetric Labor Complications
- Trial name
- SNACS Pilot (NCT04494529)
- Testing
- 24 mg betamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Dementia Prevention
e-Learning About Cognitive Impairment and Dementia Prevention
In this proposal, the investigators plan to study the effectiveness of our web-based intervention on dementia prevention knowledge, intentions, and behaviour change.
- Trial name
- NCT05383118
- Testing
- Education Intervention, Education Control
- Where
- Canada
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- McMaster University
Urothelial Carcinoma Ureter, Urothelial Cancer of Renal Pelvis
Intravesical Mitomycin C After Diagnostic Ureteroscopy for Upper Tract Urothelial Carcinoma
The objective of this pilot study is to determine the feasibility of conducting a phase III randomized trial of intravesical mitomycin C (MMC) for prevention of intravesical recurrence (IVR) after diagnostic ureteroscopy for…
- Trial name
- NCT05979909
- Testing
- Mitomycin C
- Volunteers
- 40 people
- Sponsor
- McMaster University
Fall, Intracranial Bleed
Derivation of a Clinical Decision Rule for Emergency Department Head CT Scanning in Seniors Who Have Fallen
Falls are the leading cause of traumatic death in the elderly with head injury causing half of these deaths. Each year, one in three adults over the age of 65 (seniors) fall, and half of these seniors seek treatment at a hospital…
- Trial name
- NCT03745755
- Where
- Canada
- Volunteers
- 4,308 people
- Sponsor
- McMaster University
Dupuytren's Disease
Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's
This is a prospective, multi-centre, pragmatic randomized controlled trial to compare both the clinical effectiveness and cost-effectiveness of collagenase injections (CI) versus limited palmar fasciectomy (LPF) to determine if…
- Trial name
- EXTEND (NCT02725528)
- Testing
- collagenase injection, limited palmar fasciectomy
- Where
- 10 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- McMaster University