Clinical trials: sponsored by McMaster University
Exercise, Ketosis
The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency.
- Trial name
- NCT05665855
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- McMaster University
Unexplained Infertility, Endometriosis
Probiotic and Antibiotic Therapies in Women With Unexplained Infertility
The study is designed as a proof of concept pilot study with 3 study arms to evaluate the safety and feasibility of the use of oral probiotics and/or antibiotics in women with unexplained infertility/endometriosis.
- Trial name
- NCT04955574
- Testing
- SH-DS01 + Metronidazole
- Sponsor
- McMaster University
Wet Age Related Macular Degeneration, Diabetic Macular Edema
Time to Treatment Utilizing a Tele-Retinal Referral System for wAMD and DME: A Pilot Study
In this province, optometrists are often responsible for contacting the retinal specialists' office to arrange patients to be examined for suspected emergencies or more routine referrals related to the eye.
- Trial name
- NCT01899963
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- McMaster University
Ocular Hypertension
Prophylaxis for Anti-VEGF-induced IOP Elevation
The purpose of our study is to determine the effect of prophylactic treatment with brimonidine/timolol fixed combination (Combigan®, Allergan; Dublin, IRL) or placebo therapy (Refresh tears®, Allergan; Dublin, IRL) on long-term…
- Trial name
- NCT02623023
- Testing
- Combigan, Refresh tears
- Sponsor
- McMaster University
Sarcopenia, Healthy Elderly
Exercise and Nutritional Supplementation
To understand the effects of a novel dietary supplement when used in conjunction with a healthy lifestyle exercise program and to define biomarkers that are specific to sarcopenia.
- Conditions
- Sarcopenia, Healthy Elderly, Healthy Young
- Trial name
- ENSASL (NCT03536871)
- Testing
- multi-nutrient supplement, Exercise
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Post Concussion Syndrome
mHealth Technology in the Treatment of Post-concussion Symptoms
Patients with concussion symptoms are asked by their doctors to stretch, exercise, and practice mindfulness daily. Patients can have a hard time sticking to these activities, which can cause patients to feel symptoms for longer…
- Trial name
- PERSIST (NCT05848193)
- Testing
- MyHeadHealth online application, Standard of Care
- Volunteers
- 88 people
- Sponsor
- McMaster University
Atrial Fibrillation, Venous Thromboembolism
Perioperative Anticoagulant Use for Surgery Evaluation Emergency Registry
Among patients who are receiving long-term anticoagulant therapy, whether with a direct oral anticoagulant (DOAC) or vitamin K antagonist (VKA), approximately 3-5% who require treatment interruption for a surgery will do so in an…
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Arterial Vascular Disease
- Trial name
- PAUSE-ER (NCT04195113)
- Where
- 3 sites in Canada
- Volunteers
- 242 people
- Sponsor
- McMaster University
Pulmonary Disease, Chronic Obstructive
Home Balance Pilot for Fall Reduction in COPD
There is a growing body of evidence demonstrating that older adults with COPD have important problems with their balance and a high incidence of falls compared to those of a similar age.
- Trial name
- NCT02695342
- Testing
- Home balance exercise program
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- McMaster University
Peripheral Arterial Disease
MyPADMGT Support of Out-Patients With Peripheral Arterial Disease
The investigators have developed an online program to help people with peripheral arterial disease (PAD) in their extremities to better self-manage their condition.
- Trial name
- Final_PADHSS (NCT04228549)
- Testing
- MyPADMGT, MyPADMGT + Nudging
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- McMaster University
Pulmonary Disease, COPD
Fall Risk Assessment in COPD
People with chronic obstructive pulmonary disease (COPD) have balance problems and are at risk of falling. New guidelines recommend balance assessment be included in pulmonary rehabilitation (PR) however no specific tests are…
- Trial name
- NCT03229473
- Where
- 4 sites in Canada
- Volunteers
- 94 people
- Sponsor
- McMaster University
Sarcopenia
Protein Quality to Support Increased Muscle Protein Synthesis
The age-related decline in muscle mass and strength is collectively referred to as sarcopenia. Canadian recommended daily allowance (RDA) for protein intake (0.8 g/kg/d), however, many expert groups have advocated that older…
- Trial name
- NCT04026607
- Testing
- Protein Supplementation
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diet Modification
The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation
This study evaluates the role of dietary L-tryptophan, an essential amino acid, in the activation of a specific cellular component: the aryl hydrocarbon receptor.
- Trial name
- Aryl-IMMUNE (NCT03059862)
- Testing
- L-tryptophan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Non-convulsive Seizures
Detecting Non-convulsive Seizures in the Paediatric Intensive Care Unit
The objective of this study is to determine if paediatric intensive care nurses and physicians can identify non-convulsive seizures in critically ill children using quantitative electroencephalography (EEG), in real time at the…
- Trial name
- NCT03856775
- Testing
- Quantitative EEG and Seizure detector
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Lateral Epicondylitis (Tennis Elbow)
Comparison of Platelet Rich Plasma and Alternative Therapies for the Treatment of Tennis Elbow (Lateral Epicondylitis)
"Tennis elbow" is the most common cause of lateral elbow pain, generally caused by either work or sports related repetitive strain.
- Trial name
- IMPROVE (NCT01668953)
- Testing
- Platelet Rich Plasma (PRP) Injection, Whole Blood Injection, Dry Needle Fenestration
- Where
- 2 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Exercise
Does Biological Sex Influence the Cardiac Output Response to Sprint Interval Exercise Training in Humans?
Sprint interval exercise training refers to brief repeated bouts of vigorous effort that are separated by short periods of recovery. Cardiac output refers to the amount of blood that is pumped out of the heart each minute.
- Trial name
- NCT05205538
- Testing
- Sprint interval exercise training
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- McMaster University
Multiple Chronic Conditions, Diabetes Mellitus
ACHRU Community Partnership Program for Diabetes Self-Management for Older Adults - Canada
Living with diabetes and other chronic (ongoing) conditions is common in older adults. These individuals have poorer health and higher use of health services compared to older adults with diabetes alone.
- Trial name
- ACHRU-CPP (NCT03664583)
- Testing
- ACHRU-Community Partnership Program (CPP)
- Where
- 4 sites in Canada
- Volunteers
- 295 people
- Sponsor
- McMaster University
Clostridium Difficile Infection
Efficacy of 30-day Duration of Fidaxomicin for Recurrent C. Difficile Infection
This is a medical research study designed to look at the safety and efficacy of 30-day course of fidaxomicin for treatment of recurrent CDI (Clostridium difficile Infection).
- Trial name
- NCT02395848
- Testing
- Fidaxomicin
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- McMaster University
Stroke
Optimizing Hospital-to-home Transitions for Older Adults With Stroke and Multimorbidity
Stroke is the leading cause of death and adult disability in Canada. Sixty percent of these older adults (> 65 years) will return to their homes after a stroke and will require ongoing rehabilitation.
- Trial name
- NCT04278794
- Testing
- Transitional Care Stroke Intervention (TCSI)
- Where
- 2 sites in Canada
- Volunteers
- 90 people
- Sponsor
- McMaster University
Comorbidity, Depressive Symptoms
Community Assets Supporting Transitions (CAST)
The aim of this study is to test a support program for older adults with symptoms of depression and other chronic health problems after they are discharged home from hospital.
- Trial name
- CAST (NCT03157999)
- Testing
- Intervention group (CAST)
- Where
- 4 sites in Canada
- Volunteers
- 127 people
- Sponsor
- McMaster University
Celiac Disease, Nutrient Deficiency
Zinc Deficiency Treatment in Celiac Disease: Supplementation Versus Diet
Micronutrient deficiencies are common amongst celiac disease (CeD) patients due to consumption of a restrictive and nutritionally unbalanced gluten-free diet (GFD) in addition to slow intestinal villi healing.
- Trial name
- NCT05782257
- Testing
- Zinc Supplementation, Zn-Optimized Diet
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University