Clinical trials: sponsored by McMaster University
Homelessness, Health Behavior
Peer Support for Homelessness in the Emergency Department
Peer support workers with lived experience of homelessness will provide advocacy, supportive counselling, assistance with navigating the system, and role-modeling for people experiencing homelessness in emergency departments in…
- Conditions
- Homelessness, Health Behavior, Health Care Utilization, Health Care Seeking Behavior
- Trial name
- NCT04012697
- Testing
- Peer Support
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McMaster University
COVID-19, GastroIntestinal Bleeding
Re-EValuating the Inhibition of Stress Erosions (REVISE) - COVID-19 Cohort Study
Commonly employed medications used in critically ill patients requiring life support include proton pump inhibitors (PPIs). These medications are thought to prevent gastrointestinal (GI) bleeding from stress-induced ulceration.
- Trial name
- NCT05715567
- Testing
- Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial (NCT03374800)
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Pulmonary Embolism
D-dimer Testing Tailored to Clinical Pretest Probability in Suspected Pulmonary Embolism
Prospective, multicentre, cohort study assessing a diagnostic management strategy for suspected Pulmonary Embolism with independent central adjudication of outcomes
- Trial name
- PEGeD (NCT02483442)
- Where
- 9 sites in Canada
- Volunteers
- 2,038 people
- Sponsor
- McMaster University
Old Age; Dementia, Swallowing Disorder
The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia
Swallowing impairment (dysphagia) is extremely common in older adults living with dementia due to age-related changes in swallowing and other disease-specific impairments.
- Conditions
- Old Age; Dementia, Swallowing Disorder, Cough, Parkinson Disease
- Trial name
- NCT04362228
- Testing
- Whole-body exercise
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- McMaster University
Alcohol Drinking
Enhancing Brain Processing Via Neurofeedback in Addictive Disorders
The purpose of this study is to investigate the effects of neurofeedback training on measures of cognitive control and alcohol motivation among young adults who drink alcohol on a regular basis.
- Trial name
- NCT04252755
- Testing
- EEG Neurofeedback
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Severe Prednisone Dependent Eosinophilic Asthma
Benralizumab in Patients With Inadequate Response to Anti-IL5 Monoclonal Antibody Therapies
In severe prednisone-dependent eosinophilic asthma, Benralizumab would suppress airway eosinophilia that is not suppressed by either Mepolizumab or Reslizumab and this would be associated with greater asthma control
- Trial name
- NCT03470311
- Testing
- Benralizumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Asthma
Dupilumab on Airway Hyper-responsiveness and Ventilation Heterogeneity in Patients With Asthma.
In asthmatics with airway hyperresponsiveness and a "T2 immune signature" (type 2), Dupilumab will suppress airway hyperresponsiveness (assessed by methacholine PC20 ≤ 4 mg/mL (PC20: provocative concentration causing a 20% fall…
- Trial name
- NCT03884842
- Testing
- Dupilumab/Dupixent
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Coronavirus, N95
Medical Masks vs N95 Respirators for COVID-19
A randomized controlled trial in which health care workers will be randomized to either medical masks or N95 respirators when providing care to patients with COVID-19.
- Conditions
- Coronavirus, N95, Medical Mask
- Trial name
- NCT04296643
- Testing
- Medical Mask, N95 respirator
- Where
- 15 sites in Canada, Egypt and 2 more
- Volunteers
- 1,009 people
- Sponsor
- McMaster University
Ogilvie Syndrome, Colonic Pseudo-Obstruction
Epidural for Ogilvie's Syndrome
Epidural anesthesia may represent a safe and effective pharmacological tool in the management of Ogilvie's Syndrome. This pilot study aims to demonstrate feasibility, safety, and efficacy of epidural anesthesia to set the stage…
- Trial name
- NCT04600427
- Testing
- Epidural anesthesia
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
COVID-19
Knowledge Mobilization Activities to Support Decision-Making by Youth, Parents and Adults: Study Protocol
Coronavirus Disease (COVID-19) recommendations are usually developed for healthcare professionals (for example Doctors, health organizations, etc.).
- Trial name
- eCOVID-PLR (NCT05358990)
- Testing
- Plain Language Recommendation (PLR), Standard Language Version (SLV)
- Where
- Canada
- Volunteers
- 997 people, healthy volunteers welcome
- Sponsor
- McMaster University
Intensive Care Unit Acquired Weakness, Critical Care
CYCLE Pilot Randomized Trial
Background: Patients in the intensive care unit (ICU) are the sickest in hospital, and need advanced life-support. Survivors of critical illness are very weak and disabled.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- CYCLE Pilot (NCT02377830)
- Testing
- In-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy
- Where
- 9 sites in United States, Australia and 1 more
- Volunteers
- 113 people
- Sponsor
- McMaster University
Postoperative Cognitive Dysfunction, Chronic Post Operative Pain
Chronic Postsurgical Pain, Postoperative Cognitive Dysfunction and Resilience
"Brain damage" and "memory loss" are main concerns of people undergoing surgery. In fact, many older people undergoing different types of non-cardiac surgeries (including orthopedic surgeries) present a significant decline in…
- Conditions
- Postoperative Cognitive Dysfunction, Chronic Post Operative Pain, Satisfaction, Patient, Coping Behavior
- Trial name
- ArthroCaP (NCT05614271)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Endothelial Dysfunction
Artery Function Responses to Heat Therapy and Exercise Training
This study will explore the effects of 8 weeks of local leg heat therapy, exercise training, or both on measures of vascular function, cardiorespiratory fitness, and muscle strength in young, healthy individuals.
- Trial name
- NCT04588103
- Testing
- Heat therapy, Exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Exercise, Ketosis
The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance.
- Trial name
- NCT05226962
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- McMaster University
Celiac Disease in Children, Celiac Disease
Development of CELIAC-Q KIDS: A Patient-Reported Outcome Measure for Pediatric Celiac Disease
A multicentre, prospective observational study to develop the CELIAC-Q KIDS patient reported outcome measure for children and adolescents with celiac disease.
- Conditions
- Celiac Disease in Children, Celiac Disease, Patient-reported Outcome Measures
- Trial name
- NCT05548166
- Testing
- Interview and scale development
- Where
- 2 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postoperative Cognitive Dysfunction, Depressive Symptoms
Perioperative Cognitive Trajectories in Deferred Surgery (CoTELE-SURGE)
Cognition is the way people use their brains to think, understand, remember and make decisions. Cognitive changes are often seen even up to 1 year after surgery.
- Conditions
- Postoperative Cognitive Dysfunction, Depressive Symptoms, Postoperative Pain
- Trial name
- CoTELE-SURGE (NCT04787536)
- Testing
- Non-cardiac surgery
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Pediatric Inflammatory Bowel Diseases, Pediatric Crohns Disease
Exercise Training in Youth With Inflammatory Bowel Disease
Children and adolescents with inflammatory bowel disease (IBD) suffer from many extra-intestinal side effects, including impaired muscle strength, low aerobic fitness, low bone density, and chronic inflammation.
- Conditions
- Pediatric Inflammatory Bowel Diseases, Pediatric Crohns Disease, Pediatric Ulcerative Colitis
- Trial name
- NCT05591976
- Testing
- Exercise training program
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- McMaster University
Emotion Regulation
Neuroplastic Adaptations in Youth at High Risk for Developing Psychopathology
This pilot study aims to inform decision-making for a bigger study we intend to conduct in the future. The larger investigation will explore how helpful a treatment program for youth (ages 17 - 24) with emotion dysregulation (ED)…
- Trial name
- NCT05586425
- Testing
- Emotion Regulation Skills + Treatment as Usual, Treatment as Usual
- Volunteers
- 20 people
- Sponsor
- McMaster University
Health Behavior, Quality of Life
Feasibility and Implementation of a Healthy Lifestyles Program
Chronic conditions, such as obesity and diabetes, are increasing worldwide. Lifestyle changes (e.g., physical activity, healthy diet, sufficient sleep, managing stress, smoking cessation) are often recommended to prevent or…
- Conditions
- Health Behavior, Quality of Life, Chronic Disease, Health Promotion
- Trial name
- NCT03258138
- Testing
- Health and wellness learning sessions, Brainstorming group sessions, Individual sessions with a multidisciplinary health team
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University