Clinical trials: sponsored by McMaster University
Anxiety, Insomnia
Evaluating a Group-based Therapeutic Yoga Program for Burnout
This study is evaluating a group-based therapeutic yoga program for burnout. This study aims to understand the feasibility of running the program (i.e.
- Conditions
- Anxiety, Insomnia, Burnout, Professional, Depression
- Trial name
- NCT03973216
- Testing
- A primary care group-based therapeutic yoga program
- Where
- Canada
- Sponsor
- McMaster University
Atopic Asthma
Probiotics and Capsaicin Evoked Coughs
Cough in asthma is a very common and troublesome symptom in asthma, which predicts severity and poor prognosis. Previous studies have shown that asthmatics have an exaggerated cough response to capsaicin.
- Trial name
- PCEC (NCT03603522)
- Testing
- BioGaia-DSM17938
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Generalized Anxiety Disorder, Social Anxiety Disorder
Cannabinoids for the Treatment of Anxiety Disorders: An 8-Week Pilot Study
This proposed study aims to evaluate the efficacy of a daily oral cannabinoid oil preparation in treating symptoms of DSM-5 anxiety disorders, using a two-arm, 8-week randomized, placebo-controlled trial in adults aged 21-65…
- Conditions
- Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia
- Trial name
- NCT04569760
- Testing
- 50:2 mg(CBD:THC)/ml - Cannabinoid Oil Oral Preparation- titrated as tolerated up to a maximum 8mls twice daily (200 mg- 800 mg total dose)
- Where
- Canada
- Sponsor
- McMaster University
Skin Cancer, Basal Cell, Skin Cancer
A Comparison of Skin Grafts Versus Local Flaps for Facial Skin Cancer From the Patient Perspective: A Feasibility Study
A prospective single-centered feasibility study will be conducted. The purpose of the feasibility study is to define the variables to be included in a subsequent pilot study, assess the feasibility of conducting a prospective…
- Conditions
- Skin Cancer, Basal Cell, Skin Cancer, Skin Cancer, Non-Melanoma, Skin Cancers - Squamous Cell Carcinoma
- Trial name
- NCT04805905
- Testing
- FACE-Q patient reported outcome
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hemophilia A, Hemophilia B
Web-based Application for the Population Pharmacokinetic Service - Phase 1
The aims of this trials are: 1. to collect published and unpublished individual classic pharmacokinetic data (individual patient data from independent investigators and pharmaceutical companies) 2.
- Trial name
- WAPPS (NCT02061072)
- Testing
- Population pharmacokinetic estimation
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- McMaster University
Infection, Bone Neoplasms
Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY)
The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial is the first ever international multi-center randomized controlled trial in bone cancer surgery.
- Trial name
- PARITY (NCT01479283)
- Testing
- 24-Hour Prophylactic Cefazolin* Antibiotic Regimen, 5-Days Prophylactic Cefazolin* Antibiotic Regimen
- Where
- 54 sites in United States, Argentina and 10 more
- Volunteers
- 602 people
- Sponsor
- McMaster University
Asthma, Covid19
COVID-19 Infection and Epithelial Cell Markers
To assess if TSLP expression by airway epithelial cells following COVID-19 infection regulates viral load and disease severity.
- Trial name
- NCT04787588
- Where
- Canada
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- McMaster University
Multiple Sclerosis
Exercise and Brain Health in MS
Physical activity is now recognized as a therapy for Multiple Sclerosis (MS) that not only improves physical fitness and functional mobility, but there is some evidence that it may also positively influence the more invisible…
- Trial name
- NCT03638739
- Testing
- Twice-weekly exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Diabetes Mellitus, Type 2, Hypertension
Community Health Assessment Program in the Philippines (CHAP-P)
This study aims to evaluate the effectiveness of the Community Health Assessment Program in the Philippines (CHAP-P), looking at the differences between communities implementing CHAP-P versus communities not implementing CHAP-P.
- Trial name
- CHAP-P (NCT03481335)
- Testing
- CHAP-P Sessions
- Where
- Philippines
- Volunteers
- 5,229 people, healthy volunteers welcome
- Sponsor
- McMaster University
Stroke, Cardiovascular
Cardiovascular Effects of Acute Exercise Post-Stroke
There is an urgent need to reduce the impact of stroke by promoting optimal rehabilitation strategies that decrease the risk of stroke.
- Trial name
- ACES (NCT03570216)
- Testing
- Cardiopulmonary exercise test, Moderate-intensity continuous exercise, High-intensity interval exercise
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McMaster University
Lung Cancer, Atrial Fibrillation
Determining the True Incidence of Atrial Fibrillation Before and After Lung Resection
Lung resections for pulmonary malignancies offer the best chance of survival for patients, but these procedures carry a significant burden of post-operative morbidity and mortality.
- Conditions
- Lung Cancer, Atrial Fibrillation, Stroke
- Trial name
- Lung-AF (NCT02547168)
- Testing
- iRhythm ZIO XT patch
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McMaster University
Breast Cancer
Cost-Effectiveness of Abdominal-based Autogenous Tissue vs Tissue Expander-Implant Reconstruction - A Feasibility Study
It is estimated that about 25% and 40% of health care expenditures in Canada and USA respectively are wasted because of inefficiencies and not practicing evidence-based medicine.
- Trial name
- NCT02438449
- Testing
- Breast Reconstruction Surgery
- Where
- Canada
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- McMaster University
Low-lying Unilateral Palpable Undescended Testis
Expertise-Based Randomized Controlled Trial of Scrotal Versus Inguinal Orchidopexy on Post-operative Pain
Undescended Testis is the most common congenital abnormality of the genitalia in boys and it is commonly managed by surgical intervention.
- Trial name
- EXPRESSO (NCT02158780)
- Testing
- Scrotal Orchidopexy, Inguinal Orchidopexy
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- McMaster University
Critical Illness
PICU Patient Diary
The PICU-Diary study is a prospective single centre pilot study in the Pediatric Critical Care Unit at McMaster Children's Hospital.
- Trial name
- NCT03777527
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Surgical Resection, Stereotactic Body Radiotherapy
Post SBRT Pulmonary Metastasectomy (PSPM) Trial
The goal of this study is to determine the effectiveness of SBRT on reducing tumor viability at a pathologic level and also to evaluate the effects of combined modality treatment on low volume pulmonary metastases, in hopes of…
- Conditions
- Surgical Resection, Stereotactic Body Radiotherapy, Lung Cancer, Pulmonary Metastasectomy
- Trial name
- PSPM (NCT04160143)
- Testing
- Surgical resection and stereotactic body radiation therapy (SBRT)
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- McMaster University
Urinary Catheterization, Thoracic Surgery
REduction of Post-Operative Urinary Retention With Tamsulosin Versus Placebo (REPOURT- P) Trial
The purpose of this study are to determine the efficacy of tamsulosin compared to placebo in reducing post-operative urinary retention and improving other clinical outcomes in people undergoing thoracic surgery.
- Conditions
- Urinary Catheterization, Thoracic Surgery, Thoracic Epidural Analgesia
- Trial name
- REPOURT-P (NCT04159077)
- Testing
- Tamsulosin Hydrochloride
- Volunteers
- 350 people
- Sponsor
- McMaster University
Delirium
Lived Experiences and Impact of Delirium in Critically Ill Children: a Qualitative Study
The investigators aim to conduct a qualitative study evaluating the long and short-term recollection and experiences of critically ill children with delirium as well as collect the lived experience of the caregiver and healthcare…
- Trial name
- NCT04168515
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Venous Thromboembolism, Thoracic Surgery
Incidence of Venous Thromboembolism in Patients Undergoing Major Esophageal Resection
The purpose of this study is to determine the incidence of post-operative venous thromboembolism (VTE) in patients undergoing major esophageal resection for malignancy.
- Conditions
- Venous Thromboembolism, Thoracic Surgery, Esophageal Cancer
- Trial name
- NCT03115541
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 187 people
- Sponsor
- McMaster University
Delirium, Withdrawal Syndrome
Early Rehabilitation in Critically Ill Children - The PICU Liber8 Study
This is a pilot quality improvement implementation study that will measure the impact of a rehabilitation bundle implementation on the outcomes of interest.
- Conditions
- Delirium, Withdrawal Syndrome, Hospital Acquired Condition, Critical Illness Myopathy
- Trial name
- PICULiber8 (NCT03573479)
- Testing
- PICU Liber8 Bundle
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- McMaster University
Postpartum Depression
Online 1-Day CBT-Based Workshops for PPD
Postpartum depression (PPD) already affects up to 1 in 5 women and left untreated costs $150,000 per case over the lifespan. Under normal conditions, just 10% of women with PPD get evidence-based treatment, a situation that has…
- Trial name
- NCT04485000
- Testing
- Online 1-Day Cognitive Behavioural Therapy (CBT)-Based Workshop
- Where
- Canada
- Volunteers
- 403 people
- Sponsor
- McMaster University