Clinical trials: sponsored by McMaster University
Senior High Cost Users (HCU)
Characterizing the Senior High Cost User (HCU) in Ontario
High cost users (HCUs) are a small group of patients who use a disproportionate amount of health care resources. This study is a retrospective population-based matched cohort analysis of newly incident senior High Cost Users…
- Trial name
- NCT02815930
- Testing
- HCU Status
- Volunteers
- 700,000 people
- Sponsor
- McMaster University
Multimorbidity
Self-Management Program for Older Adults With Multimorbidity
Patients with multimorbidity move between multiple care settings, and so they are at high risk of receiving fragmented care leading to increased risk for avoidable illness, death, and health care costs.
- Trial name
- NCT02209285
- Testing
- Self-Management Program for Older Adults with Multimorbidity
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- McMaster University
Pain, Postoperative, Fractures, Open
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Pilot
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Fractures, Open, Fractures, Closed
- Trial name
- COPE Pilot (NCT03673358)
- Testing
- Cognitive Behavioural Therapy
- Where
- 6 sites in Canada
- Volunteers
- 83 people
- Sponsor
- McMaster University
Atrial Fibrillation
Perioperative Anticoagulant Use for Surgery Evaluation Study Part 2 Pilot
The proposed PAUSE-2 RCT study is the logical next step to the Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) study, which was completed on August 31, 2018.
- Trial name
- PAUSE2rctP (NCT04192552)
- Testing
- PAUSE Perioperative DOAC Management, ASRA Perioperative DOAC Management
- Where
- 3 sites in Canada
- Volunteers
- 201 people
- Sponsor
- McMaster University
Crohn Disease, Ulcerative Colitis
Brief Escalation of Adalimumab Treatment for Prevention of Clinical Relapse in IBD
To examine whether a temporary three month increase in adalimumab dosing will prevent relapse in patients with inflammatory bowel disease in clinical remission who have elevated calprotectin.
- Trial name
- BEAT-IBD (NCT03059849)
- Testing
- Adalimumab
- Sponsor
- McMaster University
Skeletal Muscle Hypertrophy
Effects of a Multi-ingredient Supplement Study: a Randomized Controlled Trial in Men and Women
Resistance exercise training is a known stimulant for muscle protein synthesis (MPS) to occur, however the consumption of protein is also necessary to induce a shift towards a positive net protein balance.
- Trial name
- SRCT (NCT03525197)
- Testing
- Whey protein-based supplement, Collagen protein-based supplement
- Where
- 2 sites in Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- McMaster University
Anemia, Iron Deficiency, Iron Overload
Validation of a Point-of-care Device Measuring Ferritin With Capillary Blood
Measurement of iron is important for identifying both low and high iron levels in the body. Measuring a protein in the blood called ferritin is currently the easiest way to determine a patient's iron status.
- Conditions
- Anemia, Iron Deficiency, Iron Overload, Iron-deficiency
- Trial name
- FerPOC (NCT03800446)
- Testing
- Point of care ferritin test
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Death, Communication, Multidisciplinary
A Multicenter Implementation Study of the 3 Wishes Project
The 3 Wishes Project (3WP) was created to promote the connections between patients, family members, and clinicians that are foundational to empathic end-of-life care.
- Conditions
- Death, Communication, Multidisciplinary, Empathy, Compassion
- Trial name
- 3WP (NCT04147169)
- Testing
- Focused end-of-life conversations to promote connections among patients, family members and clinicians.
- Where
- Canada
- Volunteers
- 730 people
- Sponsor
- McMaster University
Hemophilia
Patient Reported Outcomes Burdens and Experiences - Phase 2
The Patient Reported Outcomes, Burdens, and Experiences (PROBE) Study aims to develop a new global tool to enhance the direct patient-voice in health care decision-making.
- Trial name
- PROBE (NCT02439710)
- Testing
- Quality of life measure (survey)
- Where
- Canada
- Volunteers
- 656 people
- Sponsor
- McMaster University
Palliative Care
Music Intervention on Palliative Patients
Palliative/hospice care patients experience many negative symptoms during their time in such facilities. These symptoms include, but are usually not limited to, pain, anxiety, depression, and so on.
- Trial name
- NCT03758703
- Testing
- Pre-recorded music intervention group, Pre-recorded soothing poetry group
- Where
- 2 sites in Canada
- Volunteers
- 84 people
- Sponsor
- McMaster University
Anxiety, Depressive Symptoms
The Effects of High-intensity Interval Training on Mental Health and Inflammation
The present study investigated the effects of high-intensity interval exercise training and placebo-exercise on mental health and inflammation using a randomized control trial.
- Conditions
- Anxiety, Depressive Symptoms, Inflammation
- Trial name
- NCT04118309
- Testing
- Exercise
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Health Condition
Apply the (MyTransition) App In Transition
Moving from child care to adult care is a hard time for patients and their families. Parents of children with chronic conditions say they need more support around the time of changing care.
- Trial name
- ApplyIT (NCT03188224)
- Testing
- MyTransition app
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- McMaster University
Type 2 Diabetes Mellitus, NIDDM
Comparison Study of Usual Care vs. Usual Care Plus Community Intervention to Manage Type 2 Diabetes
The overall purpose of this research is to examine and compare the effectiveness and costs of a community-based intervention to support self-management with usual primary care for older adults with Type 2 Diabetes Mellitus and…
- Conditions
- Type 2 Diabetes Mellitus, NIDDM, Non-insulin Dependent Diabetes Mellitus
- Trial name
- NCT02158741
- Testing
- Home Visits and Lifestyle Education Support
- Where
- 8 sites in Canada
- Volunteers
- 291 people
- Sponsor
- McMaster University
Ventilator Associated Pneumonia (VAP), Other Infections
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial
Probiotics are commercially available live bacteria thought to have health benefits when ingested. A literature review of probiotic studies in the intensive care unit (ICU) found that in patients who receive probiotics, there is…
- Conditions
- Ventilator Associated Pneumonia (VAP), Other Infections, Antibiotic-Associated Diarrhea, C-Difficile
- Trial name
- PROSPECT (NCT01782755)
- Testing
- L. rhamnosus GG - Probiotic
- Where
- 14 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- McMaster University
Colic
Effect of a Prebiotic on Colic and Crying and Fussing Behaviour in Infants
Colic, or inconsolable crying and fussing, affects around 20% of babies who are 3 months of age or younger. To date, there are no known treatments that have been found to help reduce colic and its symptoms in babies.
- Trial name
- CRI (NCT02586558)
- Testing
- Experimental Infant formula, Reference group
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- McMaster University
Chronic Disease, Child
Motivated to Move: A Study to Determine the Feasibility of Self-Monitoring Physical Activity in Youth
Children with a medical condition don't get enough exercise, which can lead to even more health problems in childhood and adulthood.
- Conditions
- Chronic Disease, Child, Adolescent
- Trial name
- NCT03970369
- Testing
- Usual care, Monitor
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Obesity
Evaluation of Food Additive Contributions to Obesity - Feasibility Study 2
The effects of food additives on body weight in humans are largely unknown. This is a before-and-after feasibility study in 5 obese adults who will be followed for 5 months.
- Trial name
- NCT03758378
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- McMaster University
Obesity
Evaluation of Food Additive Contributions to Obesity - Feasibility Study 1
The effects of food additives on body weight in humans are largely unknown. This is a before-and-after feasibility study in 5 obese adults who will be followed for 5 months.
- Trial name
- NCT03757962
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- McMaster University
Inflammatory Bowel Diseases
Effect of Real-world Tight Control Management of Inflammatory Bowel Disease
Inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, is a condition that causes inflammation in the gastrointestinal tract. The disease goes through periods of remission and flare.
- Trial name
- NCT03633669
- Testing
- Fecal calprotectin, Routine care
- Sponsor
- McMaster University
Atopic Dermatitis, Eczema
Eczema Reminder and Accountability Program
Eczema is a chronic disease that requires long term and extensive treatment. However patient adherence to the treatment plans provided to them by their healthcare providers is poor.
- Trial name
- ERAP (NCT03735459)
- Testing
- Patient reminders and accountability questionnaires
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McMaster University