Clinical trials: sponsored by McMaster University
Endothelial Dysfunction
Effect of Local Heat Stress Via Leg Bath on Artery Function
Arteries are flexible in their structure and function and change in response to a variety of factors. Endothelial cells, are the skin type cells that form a layer inside arteries, and they are very important for arterial health.
- Trial name
- HEAT (NCT03618524)
- Testing
- Lower limb hot water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Low Back Pain, Non Specific Low Back Pain
Which Exercise for Low Back Pain: A Validation Study
Dr. Macedo and others involved in the proposed research recently conducted a study that investigated whether simple clinical characteristics could identify patients who benefit more from either motor control exercises or graded…
- Trial name
- NCT03327753
- Testing
- Motor control exercises, Graded activity
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Atrial Fibrillation
Perioperative Anticoagulant Use for Surgery Evaluation Study
The aim of the Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) Study, is to establish a safe, standardized protocol for the perioperative management of patients with atrial fibrillation (AF) who are receiving a…
- Trial name
- PAUSE (NCT02228798)
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 3,135 people
- Sponsor
- McMaster University
Cerebrovascular Accident
Fit For Function: A Community Wellness Program for Persons With Stroke
Building on an earlier pilot study, this randomized controlled trial will compare the effectiveness of a 12 week community YMCA-based wellness program specifically designed for people with stroke (Fit for Function) to a standard…
- Trial name
- NCT02703805
- Testing
- Fit For Function Program, Standard YMCA membership
- Where
- 3 sites in Canada
- Volunteers
- 218 people
- Sponsor
- McMaster University
Muscle Protein Synthesis
Effect of Protein Quality During Overreaching in Trained Cyclists
Athletes frequently undertake periods of intensified training commonly referred to as "overreaching." These training periods acutely decrease performance, with the expectation that performance will rebound and improve after a…
- Trial name
- NCT03994198
- Testing
- Alpha-lactalbumin, Collagen peptides
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Hypertrophy, Muscle Strength
Upper Versus Lower Limb Responses to Higher Versus Lower Load Resistance Training in Young Men
Recent research suggests that performing resistance exercise training with relatively light loads is equally as effective at increasing muscle mass and muscle strength as performing resistance exercise training with relatively…
- Trial name
- NCT03993483
- Testing
- Unilateral resistance exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Illness, Comorbidities
Advance Care Planning & Goals of Care Randomized Controlled Trial in Primary Care
Sometimes people with health conditions become ill suddenly and can no longer speak for themselves and another person (such as a family member) will make health care decisions for them.
- Trial name
- NCT03434626
- Testing
- ACP Education, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Hypertrophy, Muscle Fibre Activation
Lower and Higher Load Resistance Exercise Protocols: Acute Muscle Activation and Skeletal Muscle Hypertrophy
How much weight an individual lifts per workout does not dictate the relative increase in muscle size the individual gains following weeks of training, which is contrary to current strength training dogma.
- Trial name
- NCT03991117
- Testing
- resistance exercise
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Atrophy
Effects of Amino Acid Formulation on Healthy Men Undergoing Unilateral Knee Immobilization
This is a safety and tolerability study investigating the effect of an amino acid formulation in healthy volunteers during and after limb immobilization.
- Trial name
- NCT03267745
- Testing
- Amino Acid, Breg Brace single-leg immobilization
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder
rTMS in Treatment Refractory Obsessive-Compulsive Disorder
This study will evaluate the effectiveness of rTMS as a potential treatment for refractory OCD in a randomized, crossover design.
- Trial name
- NCT02450695
- Testing
- rTMS
- Where
- Canada
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder
A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder
This study will examine the efficacy of pregabalin (Lyrica) added to SRI treatment in OCD for individuals who have not responded or only partially responded to an adequate trial of SRI.
- Trial name
- NCT00994786
- Testing
- pregabalin
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Muscle Loss
Leucine-enriched Nutraceutical and Attenuating Muscle Loss
This leucine-enriched protein gummy (as a gummy bar/slab) will be studied to address age-related loss of muscle mass and strength/function in older persons.
- Trial name
- NCT03197402
- Testing
- Leucine-enriched protein gel delivery system, Milk protein gel delivery system
- Where
- 4 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Atrophy, Disuse Atrophy (Muscle) of Lower Leg
The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation
It is well known that periods of weight training lead to increases in skeletal muscle size and strength. In contrast, periods of inactivity such as bed rest or immobilization result in losses of skeletal muscle size and strength.
- Trial name
- HYPAT (NCT03046095)
- Testing
- Unilateral Resistance Exercise, Immobilization
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Depressive Symptoms
Nurse-Led Interprofessional Mental Health Promotion Intervention for Older Home Care Clients
Objective: The objective of this study is to evaluate the feasibility, acceptability and effectiveness of a 6-month nurse-led, interprofessional mental health promotion intervention aimed at older home care clients with…
- Trial name
- NCT01407926
- Testing
- Nurse-Led Mental Health Promotion Intervention
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- McMaster University
Post Operative Pain
Use of Exparel for Postoperative Analgesia Following Bariatric Surgery
The aim of this study is to evaluate the efficacy of liposomal bupivicaine in post operative analgesia for patients undergoing bariatric surgery when compared to conventional local analgesia.
- Trial name
- NCT03975283
- Testing
- Exparel 266 MG Per 20 ML Injection, Bupivacaine Hcl 0.25% Inj
- Volunteers
- 80 people
- Sponsor
- McMaster University
Deceased Organ Donation, Critical Illness
National Observational Study of Clinical Practices in Deceased Organ Donation
This is a 1-year national prospective cohort study that observes the medical management of consented deceased organ donors at hospitals across Canada with a high volume of deceased donation.
- Conditions
- Deceased Organ Donation, Critical Illness, Transplantation
- Trial name
- CanadaDONATE (NCT03114436)
- Testing
- Observational Data Collection
- Where
- 29 sites in Canada
- Volunteers
- 622 people
- Sponsor
- McMaster University
Hand Injuries
Mirrored Movement Compared to Cross-education
Recovery after a hand or wrist injury often includes wearing a cast, or limiting daily activities to help with healing, but this may lead to deconditioning.
- Trial name
- NCT03937232
- Testing
- Cross-Education, Mirror Visual Feedback, Usual care
- Volunteers
- 80 people
- Sponsor
- McMaster University
Preterm Birth, Pregnancy
An Electronic Medical Record Alert of Progesterone
Progesterone can be given to women at risk for preterm birth, and is advocated by many guidelines as progesterone has been shown to markedly decrease preterm birth, death in newborns, and disability.
- Trial name
- NCT03219489
- Testing
- Electronic medical record alert
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- McMaster University
Infection, Wound Healing Problem
Fluid Lavage of Open Wounds (FLOW): Pilot Trial
The purpose of this trial is to investigate whether irrigation solution (soap vs. saline solution), or irrigation pressure (high vs. low) will decrease the rate of infection among patients with open fracture wounds.
- Conditions
- Infection, Wound Healing Problem, Nonunion
- Trial name
- FLOW (NCT01069315)
- Testing
- Type of fluid lavage solution, Type of fluid lavage pressure
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 111 people
- Sponsor
- McMaster University
Esophageal Cancer
Early Integration of Palliative Care in Esophageal Cancer Patients
Palliative care physicians and nurses are trained to help reduce suffering and improve quality of life in patients under their care.
- Trial name
- NCT02547142
- Testing
- Early Palliative Care
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McMaster University