Clinical trials: sponsored by McMaster University
Post-operative Delirium
Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free)
The purpose of this two-centre pilot research study is to establish the feasibility of conducting a full trial that seeks to determine if a cardiac anesthesia policy that uses alternatives to benzodiazepine medications is better…
- Trial name
- B-Free (NCT03053869)
- Testing
- Benzodiazepine - limited use strategy, Benzodiazepine - Ad libitum strategy
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- McMaster University
Aging, Fall
ABLE (Arts-Based Exercise Enhancing LongEvity)
Older adults who are referred to home care physiotherapy often only get to see the physiotherapist three to five times and are expected to continue exercising on their own.
- Conditions
- Aging, Fall, Muscle Weakness, Mobility Limitation
- Trial name
- NCT03675490
- Testing
- ABLE - exercise with interactive technology
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- McMaster University
Venous Thromboembolism, Lung Neoplasms
Extended Low-Molecular Weight Heparin VTE Prophylaxis in Thoracic Surgery
After any surgery, there is a risk of venous thromboembolism (VTE), including Deep Vein Thrombosis (DVT) in the major veins of the legs and Pulmonary Embolus (PE) in the lungs.
- Conditions
- Venous Thromboembolism, Lung Neoplasms, Pulmonary Embolism
- Trial name
- NCT02334007
- Testing
- LMWH: Dalteparin
- Where
- 2 sites in Canada
- Volunteers
- 102 people
- Sponsor
- McMaster University
Bariatric Surgery, Robotic Surgery
Robotic Versus Laparoscopic Techniques for Revisional Bariatric Surgery
Obesity has become a significant health problem in Canada. When conservative efforts to lose weight fail, bariatric surgical procedures are often considered.
- Trial name
- NCT03673410
- Testing
- Robotic bariatric surgery - revisional, Laparoscopic bariatric surgery - revisional
- Volunteers
- 60 people
- Sponsor
- McMaster University
Sepsis, Septic Shock
Fluids in Sepsis and Septic Shock
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT02748382)
- Testing
- higher chloride crystalloid, higher chloride albumin, lower chloride crystalloid
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Research Report
Comparison of Three Summary of Finding Tables to Improve Understanding in the Presentation of Systematic Review Results
Background: Summary of Findings (SoF) tables have been developed to present results of systematic reviews in a concise and explicit format.
- Trial name
- NCT02813941
- Testing
- Current GRADE SoF table, Alternative GRADE SoF table, EPC SoF table
- Where
- Canada
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- McMaster University
Autism Spectrum Disorder
Cognitive Training in Children With ASD
Plasticity refers to susceptibility of an organism to change. Cognitive training is an intervention approach based on the notion of plasticity.
- Trial name
- NCT02813564
- Testing
- Cognitive Assessment & Video-game INtervention Solutions (CAVINS)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Critical Illness
Early In-bed Cycling in Critically Ill Children
To evaluate the feasibility of conducting a randomized controlled trial (RCT) evaluating the efficacy of early in-bed cycling in addition to usual care physiotherapy, compared to usual care physiotherapy, on functional recovery…
- Trial name
- wEECycle (NCT02358577)
- Testing
- In-bed cycling, Usual Care
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Atopic Dermatitis
Effect of Oral Steroids on Skin Outcomes in Atopic Dermatitis
Atopic Dermatitis (AD), also known as eczema, is a common skin disease characterized by itchy lesions. The prevalence of AD has increased over the past few decades, with 15-30% of children and 2-10% of adults being affected.
- Trial name
- OSAD (NCT02908698)
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McMaster University
Healthy
ProbGut: Probiotics on the Healthy Gut Microbiota
In adults, probiotics have been shown to have no effect on the microbial composition and the beneficial effects are only transient. However, the gut microbiota of young children is less stable and more impressionable.
- Trial name
- NCT03430726
- Testing
- Probiotic yogurt drink
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Pediatric Critical Illness
Functional Recovery in Critically Ill Children, the Wee-Cover Multicentre Study
When children suffer from a critical-illness, the investigators focus on resuscitating and saving lives. Once these children leave the pediatric intensive care unit, very little is known about what happens to them - how long it…
- Trial name
- NCT02148081
- Where
- 2 sites in Canada
- Volunteers
- 182 people
- Sponsor
- McMaster University
Segmental Dysfunction of the Pelvic Region
Iball & Pelvic Floor Muscle Training
he postpartum period is vulnerable to dysfunction of the pelvic floor musculature, which is associated with incontinence, pain, reduced stability of the core and functional deficits.
- Trial name
- iball (NCT02865954)
- Testing
- iball (mhealth application)
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Staphylococcus Aureus Infection, MSSA Colonization
Photodisinfection for the Decolonization of Staphylococcus Aureus in Hemodialysis Patients
The purpose of the study is to evaluate whether PDT (MRSAid™) is effective in eradicating SA from hemodialysis patients who are known to harbor this organism inside their nose.
- Trial name
- NCT02741869
- Testing
- photodynamic therapy (Ondine: MRSAid™)
- Sponsor
- McMaster University
Muscle Atrophy
The Effects of 17β-estradiol on Skeletal Muscle
The maintenance of skeletal muscle mass and function is critical for healthy aging. Muscle loss with disuse, termed muscle disuse muscle atrophy, leads to impaired functional capacity, the onset of insulin resistance, as well as…
- Trial name
- NCT03069781
- Testing
- 17β-estradiol, Polycose
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Spinal Cord Injury
Repetitive Transcranial Magnetic Stimulation in Individuals With Spinal Cord Injury: A Pilot Study
This study will investigate how repetitive transcranial magnetic stimulation delivered as a protocol called 'continuous theta-burst stimulation (cTBS)' alters motor output and force control to a muscle in the forearm and touch…
- Trial name
- NCT02351921
- Testing
- Transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging
Optimal Exercise Training and Nutrition Supplementation in Older Men
As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the…
- Trial name
- NCT02281331
- Testing
- Supplement
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Clostridium Enterocolitis, Antibiotic-Associated Diarrhea
Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment
What is the difference between the use of one drug (Oral Metronidazole) versus the use of this same drug combined with another drug (Rifampin) in treatment of bacteria and infection-associated diarrhea in patients? This infection…
- Conditions
- Clostridium Enterocolitis, Antibiotic-Associated Diarrhea, Pseudomembranous Colitis, Pseudomembranous Enterocolitis
- Trial name
- NCT00182429
- Testing
- Metronidazole and Rifampin
- Where
- 4 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Osteoarthritis, Knee, Osteoarthritis, Hip
Improving Resilience and Longevity for Workers Through Exercise
The purpose of this study is to examine the impact of an OA-specific aerobic and strengthening exercise program, delivered within the workplace, on mobility, pain, physical capacity, and resilience among workers with knee or hip…
- Trial name
- NCT03050320
- Testing
- Exercise, No Exercise
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Physical Activity, Children, Only
Program Evaluation of an In-school Daily Physical Activity Initiative
The school system is one setting in which children's physical activity levels may be increased through daily physical activity (DPA) policies and initiatives.
- Trial name
- NCT03618927
- Testing
- Daily physical activity intervention
- Where
- Canada
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- McMaster University
Surgical Site Infection
Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection
The CDC quotes a rate of wound infection of 2-5% for inpatient surgery. Patients undergoing a vascular operation, however, are generally at an increased risk of wound infection with rates often close to 5-10%.
- Trial name
- NCT03308253
- Testing
- Stimulan Rapid Cure, Vancomycin, Tobramycin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University