Clinical trials: sponsored by McMaster University
Diabetes Mellitus, Type 1, Gastroparesis
The Effect of Gluten-free Diet in Type 1 Diabetics With Dyspepsia Symptoms
Patients with type-1 diabetes are more susceptible to motility-related upper gastrointestinal symptoms. Dietary interventions are one of the treatment pillars for these symptoms.
- Conditions
- Diabetes Mellitus, Type 1, Gastroparesis, Dyspepsia, Gluten Sensitivity
- Trial name
- NCT03089632
- Testing
- Gluten-free diet
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Fracture
Early Range of Motion in 5th Metacarpal Fracture
Fractures of the fifth metacarpal neck are the most common injury involving the upper extremity. Patients are typically young adult males.
- Trial name
- NCT02441790
- Testing
- Early Active Range of Motion, Standard Immobilization
- Where
- Canada
- Sponsor
- McMaster University
Troponin, Critical Care
Prognostic Value of Elevated Troponins in Critical Illness Study: A Pilot Study
Troponins are sensitive and specific markers of cardiac injury. Critically ill patients frequently have elevated troponins. In this population, distinguishing patients with elevated troponins from those with myocardial infarction…
- Conditions
- Troponin, Critical Care, Myocardial Infarction
- Trial name
- PRO-TROPICS (NCT02285686)
- Volunteers
- 251 people
- Sponsor
- McMaster University
Medical and Nursing Students' Evidence Retrieval Skills
Increasing Medical and Nursing Students Searching of Current Best Evidence to Answer Clinical Questions
Translation of new knowledge from research into evidence-informed health care is a shared obligation of the clinical and the scientific communities.
- Trial name
- MPFS-2 (NCT02240095)
- Testing
- Intervention A - Online Clinical Questions Recorder, Intervention B - Online Evidence Retrieval Coach, Intervention C - Online Audit and Feedback
- Where
- Canada
- Volunteers
- 960 people
- Sponsor
- McMaster University
Stress, Psychological
Study on the Effects of a Probiotic on Autonomic and Psychological Stress
The purpose of this study is to investigate the effects of a probiotic blend on qualitative (subjective interviews and self-reporting) and quantitative (changes in brain activity, heart rate, cortisol, and reactivity) measures of…
- Trial name
- NCT02417454
- Testing
- ProbioStick
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes Mellitus, Hypertension
TAPESTRY With Health Connnectors for Diabetes Management
The TAPESTRY-HC-DM approach is designed to support self-management of chronic disease by strengthening connections between patients and the primary healthcare system through "health connectors" -both volunteers and technology…
- Trial name
- TAP-HC-DM (NCT02715791)
- Testing
- TAP-HC-DM, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Bone Fractures
InterNational ORthopaedic MUlticenter Study in Fracture Care
Background: Worldwide injuries from trauma accidents represents a major population problem. The World Health Organization (WHO) has deemed this problem as one of the most important global priorities, calling 2011-2021 the Global…
- Trial name
- INORMUS (NCT02014974)
- Where
- India
- Volunteers
- 4,822 people
- Sponsor
- McMaster University
Osteoarthritis
Yoga as an Intervention for Women With Knee Osteoarthritis
Keeping individuals with knee osteoarthritis physically active is critically important. Exercise is effective at reducing pain while improving physical function.
- Trial name
- NCT02146105
- Testing
- Yoga For Knee Osteoarthritis
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- McMaster University
Asthma in Children, Allergy in Children
Project 500 CHILD Study
This proposal relates to the testing of several specific hypotheses in a subset of 500 participants in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.
- Conditions
- Asthma in Children, Allergy in Children, Environmental Exposure, Genetic Predisposition
- Trial name
- NCT03225534
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity, Pregnancy
A Clinical Care Pathway for Obese Pregnant Women: A Pilot Cluster RCT
Clinics will be randomized to the use of the care pathway for obese pregnant women or standard care. Women who are (1) up to 20 weeks + 6 days gestation into their pregnancy, (2) are carrying one baby (not twins) that is healthy…
- Trial name
- NCT02534051
- Testing
- Clinical Care Pathway
- Where
- Canada
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- McMaster University
Breast Reduction, Reduction Mammoplasty
Risk of Hematoma After Ketorolac Use in Reduction Mammoplasty.
The investigators hope to answer the question, "does ketorolac increase the risk of hematoma after reduction mammoplasty?" using a case-control study.
- Conditions
- Breast Reduction, Reduction Mammoplasty, Hematoma, Hemorrhage
- Trial name
- NCT03280043
- Testing
- Hematoma
- Where
- 2 sites in Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- McMaster University
Tuberculosis
Study of the Safety and Immunogenicity of an Adenovirus-based Tuberculosis Vaccine
The purpose of this Phase 1 study is to evaluate the safety and immune responses of a new tuberculosis vaccine, Ad5Ag85A, administered to healthy volunteers.
- Trial name
- NCT00800670
- Testing
- Ad5Ag85A
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Individuals (Clinicians)
Do Clinicians Want Recommendations?
The use of the best evidence available for decision-making is nowadays an undisputed goal in health care. However, this is not always achieved in the context of clinical practice.
- Trial name
- NCT02006017
- Testing
- Evidence summary alone plus a recommendation, Evidence summary alone
- Where
- Canada
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- McMaster University
Palliative Care, Primary Care
Introducing the Palliative Care Comprehensive Tool in Family Medicine
The purpose of this study is to pilot the introduction of a newly developed palliative care tool to clinicians in a family health team.
- Conditions
- Palliative Care, Primary Care, Satisfaction
- Trial name
- NCT03267706
- Testing
- Palliative Care Comprehensive Tool
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- McMaster University
Lymphedema
Acupuncture for Lymphedema Secondary to Breast Cancer Treatment
This study is being conducted to determine if electro-acupuncture can reduce swelling of the arm due to breast cancer treatment (commonly referred to as 'lymphedema').
- Trial name
- NCT02158832
- Testing
- Acupuncture + Electrical Stimulation
- Where
- Canada
- Sponsor
- McMaster University
Osteoporosis, Postmenopausal, Osteopenia
Validation, Reliability and Pilot Test of the Personalized Exercise Questionnaire (PEQ)
The PEQ is the first tool to measure facilitators, barriers, and preferences to exercise in people with osteoporosis.
- Trial name
- NCT03125590
- Testing
- Testing the PEQ (Personalized Exercise Questionnaire)
- Where
- Canada
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- McMaster University
Influenza
A Trial of Oseltamivir in High-Risk Patients Presenting to the Emergency Department With Influenza
A multi-centre, randomized, placebo controlled, trial. Participants will be patients either ≥65 years or with one or more high risk conditions presenting to one of four academic emergency departments in Edmonton or Calgary with…
- Trial name
- NCT02561169
- Testing
- Oseltamivir
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- McMaster University
Healthy Volunteers
Homeopathic Vaccine Trial
The purpose of the study is to compare the immunological response of homeopathic vaccines to placebo and to conventional vaccines in healthy young adults.
- Trial name
- HVT (NCT02825368)
- Testing
- MMR, Tdap, Diphtherinum®
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Venous Thromboembolism, Deep Vein Thrombosis
Fixed Dose Heparin Study
FIDO was a multicentred randomized, open-label trial that compared fixed-dose UFH with fixed-dose LMWH for initial treatment of VTE. Patients were followed for 3 months during which they received warfarin (target INR 2.0-3.0).
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT00182403
- Testing
- UFH 250 U/kg or LMWH 100 U/kg sc twice daily
- Where
- 8 sites in Canada, New Zealand
- Volunteers
- 866 people
- Sponsor
- McMaster University
GERD
A Prospective Blinded Randomized Study Comparing Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-y Gastric Bypass and Their Effect on Gastro-Esophageal Reflux Disease Using 24 Horus pH Monitoring
Obesity has become a significant health problem in Canada. It is known to be a risk factor for many diseases, including Gastro-Esophageal Reflux Disease (GERD).
- Trial name
- GERD (NCT02142998)
- Testing
- 24 pH monitoring, Esophageal Manometry:
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University