Clinical trials: sponsored by McMaster University
GERD
A Prospective Blinded Randomized Study Comparing Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-y Gastric Bypass and Their Effect on Gastro-Esophageal Reflux Disease Using 24 Horus pH Monitoring
Obesity has become a significant health problem in Canada. It is known to be a risk factor for many diseases, including Gastro-Esophageal Reflux Disease (GERD).
- Trial name
- GERD (NCT02142998)
- Testing
- 24 pH monitoring, Esophageal Manometry:
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Breast Cancer Screening, MRI Guided Breast Biopsy
Study to Demonstrate the Preliminary Safety and Effectiveness of IPBS in Performing MRI-Guided Targeting and Intervention of Breast Tissue in Female Patients Indicated for MRI-Guided Breast Biopsy
A preliminary demonstration of the Safety of IPBS in positioning a vacuum assisted biopsy (VAB) tool to enable an MRI-guided automated breast biopsy.
- Conditions
- Breast Cancer Screening, MRI Guided Breast Biopsy, Breast Cancer Diagnosis
- Trial name
- NCT01885741
- Testing
- IPBS
- Where
- 2 sites in Canada
- Volunteers
- 9 people
- Sponsor
- McMaster University
Venous Thromboembolism
Safety of a Diagnostic Strategy With D-Dimer Testing for PE
To determine whether D-Dimer testing, using the MDA D-Dimer assay, can be used to simplify the diagnostic process for pulmonary embolism (PE). This will be assessed by performing a cohort study in 1000 patients with suspected PE.
- Trial name
- NCT00182221
- Testing
- MDA D-Dimer Testing
- Where
- 4 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- McMaster University
Hip Fracture
Body Weight Supported Treadmill Training Following Hip Fracture
Achieving independent ambulation is an important goal of hip fracture rehabilitation, as it is predictive of returning to the community and of future health problems.
- Trial name
- NCT00197496
- Testing
- Body weight supported treadmill training
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McMaster University
Stroke
Physical Activity Maintenance in Stroke
It is essential that individuals living with stroke engage in physical activity to improve cardiovascular risk factors and reduce the risk of stroke (Billinger et al, 2014).
- Trial name
- NCT02681393
- Testing
- Brochure and Telephone Support, Brochure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Use of Research Evidence
Effects of an Evidence Service on Health System Policymakers' Use of Research Evidence
The investigators have developed an online database called 'Health Systems Evidence,' which contains synthesized research evidence and additional details about this evidence that can make it easier for health system policymakers…
- Trial name
- NCT01307228
- Testing
- Health Systems Evidence
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Venous Thromboembolism, Fetal Death
Fetal Loss in Women With Unprovoked Thromboembolism (FLUTE)
The purpose of this study is to determine the risk of fetal loss in women with unprovoked venous thromboembolism (VTE) who do not have identifiable inherited thrombophilia compared with women who have the diagnosis of venous…
- Trial name
- NCT00149357
- Testing
- Thrombophilia Testing
- Where
- 5 sites in Australia, Canada
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- McMaster University
Child Development
Play and Pre-Literacy Among Young Children
Children begin to develop fundamental motor skills (FMS), such as running and kicking, and pre-literacy skills, such as rhyming, during early childhood.
- Trial name
- PLAY (NCT02432443)
- Testing
- Motor and pre-literacy program, Wait-list Comparison
- Where
- 2 sites in Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- McMaster University
Osteoarthritis, Knee
A Biomechanical Exercise Program for Knee OA
Prescribing exercise for people with painful knee osteoarthritis (OA) is essential for pain management, improved function, and chronic disease prevention.
- Trial name
- NCT02370667
- Testing
- Biomechanical Exercise (BE), Traditional Exercise (TE), Meditation Control (M)
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- McMaster University
Older Adults, Reduced Physical Activity
Step-reduction in Older Men and Women
This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.
- Trial name
- CDA-SR (NCT03039556)
- Testing
- Normal Daily Steps, Step-Reduction, Return to Normal Daily Steps
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- McMaster University
Weight-Lifting Exercise Program
Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.
- Trial name
- NCT02842593
- Testing
- Lower-repetition, heavier-load, Higher-repetition, lighter-load
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Heart Failure
Caregiver Enhanced Assistance and Support for the Elderly Heart Failure Patient at Hospital Discharge (CEASE-HF)
Close to ninety percent of older heart failure (HF) patients have some cognitive deficits at hospital discharge which may impact their ability to make effective decisions about their healthcare.
- Trial name
- CEASE-HF (NCT01886534)
- Testing
- Standardized Heart Failure Discharge Summary to Primary Care Physicians©, Standardized education sessions, Heart Failure Diuretic Decision Support Tool for Patient Self Management©
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- McMaster University
Esophageal Achalasia
To Assess the Feasibility of Same Day Discharge Following a POEM Procedure
This is a study of an investigational surgical procedure for the treatment of achalasia the inability of smooth muscle to move food down the esophagus.
- Trial name
- POEM2 (NCT02572193)
- Testing
- POEM
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Metabolic Syndrome X
Telmisartan-Induced Reduction in Intra-Myocellular Lipids Trial
The purpose of this study is to determine whether telmisartan and/or a low-glycemic index diet are effective in reducing intra-myocellular lipid (muscle fat) content.
- Trial name
- NCT00147264
- Testing
- Low-Glycemic Index Diet vs. Control Diet
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- McMaster University
Deep Vein Thrombosis, Pulmonary Embolism
D-dimer to Select Patients With First Unprovoked Venous Thromboembolism Who Can Have Anticoagulants Stopped at 3 Months
The purpose of this study is to determine if the risk of recurrent venous thromboembolism (VTE) after stopping therapy is low and acceptable in patients with a first unprovoked proximal deep vein thrombosis (DVT) or pulmonary…
- Trial name
- DODS (NCT00720915)
- Testing
- Discontinue anticoagulant therapy (Negative d-dimer), Continue on anticoagulant therapy (positive d-dimer)
- Where
- 13 sites in United States, Canada and 2 more
- Volunteers
- 410 people
- Sponsor
- McMaster University
Colorectal Cancer
Prehabilitation in Elective Colorectal Resection: A Pilot Study (Prehab)
This is a pilot study designed to evaluate a programme of rehabilitation for patients undergoing elective colorectal resection surgery.
- Trial name
- Prehab (NCT02531620)
- Testing
- Physiatry Assessment, Routine Care
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McMaster University
Respiratory Infection
A Randomized Trial of Vitamin D to Reduce Respiratory Infection
The goal of this study is to assess the effectiveness of vitamin D in reducing laboratory-confirmed influenza and in reducing non-influenza viral respiratory tract infections.
- Trial name
- NCT01705314
- Testing
- vitamin D supplements
- Where
- Vietnam
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postoperative Confusion
Haloperidol Prophylaxis in Cardiac Surgery for Patients at Risk for Delirium
Will the use of prophylactic Haloperidol for patients undergoing open heart surgery reduce the incidence, duration, and severity of post cardiotomy delirium?
- Trial name
- HALPCARD (NCT01862302)
- Testing
- Haloperidol
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- McMaster University
Breech Presentation
Early External Cephalic Version (ECV) 2 Trial
For women with a fetus in breech presentation, does early ECV (at 34 0/7 up to 35 weeks and 6/7 days) versus delayed ECV (not before 37 weeks and 0/7 days) increase or decrease the likelihood of cesarean section (CS)?
- Trial name
- NCT00141687
- Testing
- Early ECV between 34 0/7 and 35 6/7 weeks, Delayed ECV at or after 37 0/7 weeks
- Where
- Canada
- Volunteers
- 1,543 people
- Sponsor
- McMaster University
Chronic Pain
Chronic Pain Self-management Support With Pain Education and Exercise
The purpose of this study is to determine whether the combination of self-management support, pain science education, and individualized, goal-oriented exercises helps people with chronic pain to increase their function.
- Trial name
- COMMENCE (NCT02422459)
- Testing
- COMMENCE
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- McMaster University